Escherichia coli K-12 (iJR904 GSM/GPR), 2003-09-05 Alanine and aspartate metabolism L-alanine transaminase (ALATA_L) EC-2.6.1.2 1 akg -1 3 ala-L -1 3 glu-L 1 3 pyr 1 3 alanine racemase (ALAR) EC-5.1.1.1 1 ala-L -1 3 ala-D 1 3 L-asparaginase (ASNN) EC-3.5.1.1 0 asn-L -1 3 h2o -1 3 asp-L 1 3 nh4 1 3 asparagine synthetase (ASNS2) EC-6.3.1.1 0 asp-L -1 3 atp -1 3 nh4 -1 3 amp 1 3 asn-L 1 3 h 1 3 ppi 1 3 asparagine synthase (glutamine-hydrolysing) (ASNS1) EC-6.3.5.4 0 asp-L -1 3 atp -1 3 gln-L -1 3 h2o -1 3 amp 1 3 asn-L 1 3 glu-L 1 3 h 1 3 ppi 1 3 L-aspartase (ASPT) EC-4.3.1.1 0 asp-L -1 3 fum 1 3 nh4 1 3 aspartate transaminase (ASPTA) EC-2.6.1.1 1 akg -1 3 asp-L -1 3 glu-L 1 3 oaa 1 3 Valine-pyruvate aminotransferase (VPAMT) EC-2.6.1.66 0 3mob -1 3 ala-L -1 3 pyr 1 3 val-L 1 3 D-Amino acid dehydrogenase (DAAD) EC-1.4.99.1 0 ala-D -1 3 fad -1 3 h2o -1 3 fadh2 1 3 nh4 1 3 pyr 1 3 alanine racemase (irreversible) (ALARi) EC-5.1.1.1 0 ala-L -1 3 ala-D 1 3 Alternate Carbon Metabolism beta-fructofuranosidase (FFSD) EC-3.2.1.26 0 h2o -1 3 suc6p -1 3 fru 1 3 g6p 1 3 arabinose-5-phosphate isomerase (A5PISO) EC-5.3.1.13 1 ru5p-D -1 3 ara5p 1 3 methylmalonyl-CoA epimerase (MME) EC-5.1.99.1 1 mmcoa-R -1 3 mmcoa-S 1 3 2-methylisocitrate dehydratase (MICITD) EC-4.2.1.99 0 2mcacn -1 3 h2o -1 3 micit 1 3 alcohol dehydrogenase (glycerol) (ALCD19) EC-1.1.1.1 1 glyald -1 3 h -1 3 nadh -1 3 glyc 1 3 nad 1 3 lactaldehyde dehydrogenase (LCADi) EC-1.2.1.22 0 h2o -1 3 lald-L -1 3 nad -1 3 h 2 3 lac-L 1 3 nadh 1 3 Tagatose-bisphosphate aldolase (TGBPA) EC-4.1.2.40 1 tagdp-D -1 3 dhap 1 3 g3p 1 3 lactaldehyde dehydrogenase (LCAD) EC-1.2.1.22 1 h2o -1 3 lald-L -1 3 nad -1 3 h 2 3 lac-L 1 3 nadh 1 3 aldehyde dehydrogenase (acetaldehyde, NAD) (ALDD2x) EC-1.2.1.3 0 acald -1 3 h2o -1 3 nad -1 3 ac 1 3 h 2 3 nadh 1 3 L-arabinose isomerase (ARAI) EC-5.3.1.4 1 arab-L -1 3 rbl-L 1 3 L-ribulokinase (L-ribulose) (RBK_L1) EC-2.7.1.16 0 atp -1 3 rbl-L -1 3 adp 1 3 h 1 3 ru5p-L 1 3 L-ribulose-phosphate 4-epimerase (RBP4E) EC-5.1.3.4 1 ru5p-L -1 3 xu5p-D 1 3 acetyl-CoA:acetoacetyl-CoA transferase (ACACCT) 0 acac -1 3 accoa -1 3 aacoa 1 3 ac 1 3 Acetyl-CoA:butyrate-CoA transferase (BUTCT) EC-2.8.3.8 0 accoa -1 3 but -1 3 ac 1 3 btcoa 1 3 Arbutin 6-phosphate glucohydrolase (AB6PGH) EC-3.2.1.86 0 arbt6p -1 3 h2o -1 3 g6p 1 3 hqn 1 3 phosphomannomutase (PMANM) EC-5.4.2.8 1 man1p -1 3 man6p 1 3 phosphopentomutase 2 (deoxyribose) (PPM2) EC-5.4.2.7 1 2dr1p -1 3 2dr5p 1 3 phosphopentomutase (PPM) EC-5.4.2.7 1 r1p -1 3 r5p 1 3 deoxyribose-phosphate aldolase (DRPA) EC-4.1.2.4 0 2dr5p -1 3 acald 1 3 g3p 1 3 galactonate dehydratase (GALCTND) EC-4.2.1.6 0 galctn-D -1 3 2dh3dgal 1 3 h2o 1 3 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (DDPGALA) EC-4.1.2.21 1 2dh3dgal6p -1 3 g3p 1 3 pyr 1 3 2-dehydro-3-deoxygalactonokinase (DDGALK) EC-2.7.1.58 0 2dh3dgal -1 3 atp -1 3 2dh3dgal6p 1 3 adp 1 3 h 1 3 Dihydroxyacetone phosphotransferase (DHAPT) 0 dha -1 3 pep -1 3 dhap 1 3 pyr 1 3 fatty acid oxidation (Butanoyl-CoA ) (FAO4) 0 btcoa -1 3 fad -1 3 h2o -1 3 nad -1 3 aacoa 1 3 fadh2 1 3 h 1 3 nadh 1 3 phenylacetaldehyde dehydrogenase (ALDD19x) EC-1.2.1.39 0 h2o -1 3 nad -1 3 pacald -1 3 h 2 3 nadh 1 3 pac 1 3 fructose-1-phosphate kinase (FRUK) EC-2.7.1.56 0 atp -1 3 f1p -1 3 adp 1 3 fdp 1 3 h 1 3 L-fuculose 1-phosphate aldolase (FCLPA) EC-4.1.2.17 1 fc1p -1 3 dhap 1 3 lald-L 1 3 L-fucose isomerase (FCI) EC-5.3.1.25 1 fuc-L -1 3 fcl-L 1 3 L-fuculokinase (FCLK) EC-2.7.1.51 0 atp -1 3 fcl-L -1 3 adp 1 3 fc1p 1 3 h 1 3 lacaldehyde reductase (LCAR) EC-1.1.1.77 1 h -1 3 lald-L -1 3 nadh -1 3 12ppd-S 1 3 nad 1 3 UDPglucose 4-epimerase (UDPG4E) EC-5.1.3.2 1 udpg -1 3 udpgal 1 3 galactokinase (GALKr) EC-2.7.1.6 1 atp -1 3 gal -1 3 adp 1 3 gal1p 1 3 h 1 3 UDPglucose--hexose-1-phosphate uridylyltransferase (UGLT) EC-2.7.7.12 1 gal1p -1 3 udpg -1 3 g1p 1 3 udpgal 1 3 UTP-glucose-1-phosphate uridylyltransferase (GALU) EC-2.7.7.9 1 g1p -1 3 h -1 3 utp -1 3 ppi 1 3 udpg 1 3 galactarate dehydratase (GALCTD) EC-4.2.1.42 0 galct-D -1 3 5dh4dglc 1 3 h2o 1 3 Galactitol-1-phosphate dehydrogenase (GLTPD) EC-Undetermined 1 galt1p -1 3 nad -1 3 h 1 3 nadh 1 3 tag6p-D 1 3 Glycolate oxidase (GLYCTO2) 0 glyclt -1 3 q8 -1 3 glx 1 3 q8h2 1 3 Glycolate oxidase (GLYCTO3) 0 glyclt -1 3 mqn8 -1 3 glx 1 3 mql8 1 3 Glycolate oxidase (GLYCTO4) 0 2dmmq8 -1 3 glyclt -1 3 2dmmql8 1 3 glx 1 3 Glycerol dehydrogenase (GLYCDx) EC-1.1.1.6 0 glyc -1 3 nad -1 3 dha 1 3 h 1 3 nadh 1 3 glycerol kinase (GLYK) EC-2.7.1.30 0 atp -1 3 glyc -1 3 adp 1 3 glyc3p 1 3 h 1 3 Phosphoglycolate phosphatase (PGLYCP) EC-3.1.3.18 0 2pglyc -1 3 h2o -1 3 glyclt 1 3 pi 1 3 glycerol-3-phosphate dehydrogenase (NADP) (G3PD2) EC-1.1.1.94 1 glyc3p -1 3 nadp -1 3 dhap 1 3 h 1 3 nadph 1 3 5-dehydro-4-deoxyglucarate aldolase (GLCRAL) EC-4.1.2.20 0 5dh4dglc -1 3 2h3oppan 1 3 pyr 1 3 2,3-dihydroxyphenylpropionate dehydrogenase (DHPPD) 0 cechddd -1 3 nad -1 3 dhpppn 1 3 h 1 3 nadh 1 3 2,3-dihydroxycinnamate dehydrogenase (DHCIND) 0 cenchddd -1 3 nad -1 3 dhcinnm 1 3 h 1 3 nadh 1 3 Phenylpropanoate Dioxygenase (PPPNDO) 0 h -1 3 nadh -1 3 o2 -1 3 pppn -1 3 cechddd 1 3 nad 1 3 Cinnamate dioxygenase (CINNDO) 0 cinnm -1 3 h -1 3 nadh -1 3 o2 -1 3 cenchddd 1 3 nad 1 3 hydroxypyruvate isomerase (HPYRI) EC-5.3.1.22 1 hpyr -1 3 2h3oppan 1 3 L-idonate 5-dehydrogenase (IDOND) 1 5dglcn -1 3 h -1 3 nadh -1 3 idon-L 1 3 nad 1 3 L-indonate 5-dehydrogenase (NADP) (IDOND2) 0 5dglcn -1 3 h -1 3 nadph -1 3 idon-L 1 3 nadp 1 3 gluconokinase (GNK) EC-2.7.1.12 0 atp -1 3 glcn -1 3 6pgc 1 3 adp 1 3 h 1 3 5-dehydro-D-gluconate reductase (5DGLCNR) EC-1.1.1.69 1 5dglcn -1 3 h -1 3 nadph -1 3 glcn 1 3 nadp 1 3 2-dehydro-3-deoxygluconokinase (DDGLK) EC-2.7.1.45 0 2ddglcn -1 3 atp -1 3 2ddg6p 1 3 adp 1 3 h 1 3 b-galactosidase (LACZ) EC-3.2.1.23 0 h2o -1 3 lcts -1 3 gal 1 3 glc-D 1 3 Maltodextrin phosphorylase (maltopentaose) (MLTP1) 1 maltpt -1 3 pi -1 3 g1p 1 3 maltttr 1 3 Maltodextrin phosphorylase (maltohexaose) (MLTP2) 1 malthx -1 3 pi -1 3 g1p 1 3 maltpt 1 3 Maltodextrin phosphorylase (maltoheptaose) (MLTP3) 1 malthp -1 3 pi -1 3 g1p 1 3 malthx 1 3 Amylomaltase (maltotriose) (AMALT1) EC-2.4.1.25 0 malt -1 3 malttr -1 3 glc-D 1 3 maltttr 1 3 Amylomaltase (maltotetraose) (AMALT2) EC-2.4.1.25 0 malt -1 3 maltttr -1 3 glc-D 1 3 maltpt 1 3 Amylomaltase (maltopentaose) (AMALT3) EC-2.4.1.25 0 malt -1 3 maltpt -1 3 glc-D 1 3 malthx 1 3 Amylomaltase (maltohexaose) (AMALT4) EC-2.4.1.25 0 malt -1 3 malthx -1 3 glc-D 1 3 malthp 1 3 Maltodextrin glucosidase (maltotriose) (MLTG1) 0 h2o -1 3 malttr -1 3 glc-D 1 3 malt 1 3 Maltodextrin glucosidase (maltotetraose) (MLTG2) 0 h2o -1 3 maltttr -1 3 glc-D 1 3 malttr 1 3 Maltodextrin glucosidase (maltopentaose) (MLTG3) 0 h2o -1 3 maltpt -1 3 glc-D 1 3 maltttr 1 3 Maltodextrin glucosidase (maltohexaose) (MLTG4) 0 h2o -1 3 malthx -1 3 glc-D 1 3 maltpt 1 3 Maltodextrin glucosidase (maltoheptaose) (MLTG5) 0 h2o -1 3 malthp -1 3 glc-D 1 3 malthx 1 3 mannose-6-phosphate isomerase (MAN6PI) EC-5.3.1.8 1 man6p -1 3 f6p 1 3 a-galactosidase (melibiose) (GALS3) EC-3.2.1.22 0 h2o -1 3 melib -1 3 gal 1 3 glc-D 1 3 3-hydroxycinnamate hydroxylase (3HCINNMH) 0 3hcinnm -1 3 h -1 3 nadh -1 3 o2 -1 3 dhcinnm 1 3 h2o 1 3 nad 1 3 3-(3-hydroxy-phenyl)propionate hydroxylase (3HPPPNH) 0 3hpppn -1 3 h -1 3 nadh -1 3 o2 -1 3 dhpppn 1 3 h2o 1 3 nad 1 3 2,3-dihydroxycinnamate 1,2-dioxygenase (DHCINDO) 0 dhcinnm -1 3 o2 -1 3 hkntd 1 3 2,3-dihydroxypheylpropionate 1,2-dioxygenase (HPPPNDO) EC-1.13.11.16 0 dhpppn -1 3 o2 -1 3 hkndd 1 3 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase (HKNDDH) 0 h2o -1 3 hkndd -1 3 h 2 3 op4en 1 3 succ 1 3 2-hydroxy-6-ketononotrienedioate hydrolase (HKNTDH) 0 h2o -1 3 hkntd -1 3 fum 1 3 h 2 3 op4en 1 3 2-oxopent-4-enoate hydratase (OP4ENH) EC-4.2.1.80 0 h2o -1 3 op4en -1 3 4h2opntn 1 3 4-hydroxy-2-oxopentanoate aldolase (HOPNTAL) 0 4h2opntn -1 3 acald 1 3 pyr 1 3 acetaldehyde dehydrogenase (acetylating) (ACALDi) EC-1.2.1.10 0 acald -1 3 coa -1 3 nad -1 3 accoa 1 3 h 1 3 nadh 1 3 mannitol-1-phosphate 5-dehydrogenase (M1PD) EC-1.1.1.17 1 mnl1p -1 3 nad -1 3 f6p 1 3 h 1 3 nadh 1 3 N-acetylglucosamine-6-phosphate deacetylase (AGDC) EC-3.5.1.25 0 acgam6p -1 3 h2o -1 3 ac 1 3 gam6p 1 3 glucosamine-6-phosphate deaminase (G6PDA) EC-3.5.99.6 0 gam6p -1 3 h2o -1 3 f6p 1 3 nh4 1 3 N-Acetylneuraminate lyase (ACNML) EC-4.1.3.3 0 acnam -1 3 acmana 1 3 pyr 1 3 alpha,alpha-trehalose-phosphate synthase (UDP-forming) (TRE6PS) EC-2.4.1.15 0 g6p -1 3 udpg -1 3 h 1 3 tre6p 1 3 udp 1 3 trehalose-phosphatase (TRE6PP) EC-3.1.3.12 0 h2o -1 3 tre6p -1 3 pi 1 3 tre 1 3 phenylacetate-CoA ligase (PACCOAL) EC-6.2.1.30 0 atp -1 3 coa -1 3 pac -1 3 amp 1 3 phaccoa 1 3 ppi 1 3 Phosphofructokinase (PFK_2) EC-2.7.1.11 0 atp -1 3 tag6p-D -1 3 adp 1 3 h 1 3 tagdp-D 1 3 phosphoglucomutase (PGMT) EC-5.4.2.2 1 g1p -1 3 g6p 1 3 methylisocitrate lyase (MCITL2) EC-4.1.3.30 1 micit -1 3 pyr 1 3 succ 1 3 2-methylcitrate synthase (MCITS) EC-4.1.3.31 0 h2o -1 3 oaa -1 3 ppcoa -1 3 2mcit 1 3 coa 1 3 h 1 3 2-methylcitrate dehydratase (MCITD) EC-4.2.1.79 0 2mcit -1 3 2mcacn 1 3 h2o 1 3 acetate-CoA ligase (ADP-forming) (ACCOAL) EC-6.2.1.13 0 atp -1 3 coa -1 3 ppa -1 3 adp 1 3 pi 1 3 ppcoa 1 3 Phosphate acetyltransferase (PTA2) 0 pi -1 3 ppcoa -1 3 coa 1 3 ppap 1 3 ribokinase (RBK) EC-2.7.1.15 0 atp -1 3 rib-D -1 3 adp 1 3 h 1 3 r5p 1 3 L-rhamnose isomerase (RMI) EC-5.3.1.14 1 rmn -1 3 rml 1 3 rhamnulokinase (RMK) EC-2.7.1.5 0 atp -1 3 rml -1 3 adp 1 3 h 1 3 rml1p 1 3 Rhamnulose-1-phosphate aldolase (RMPA) EC-4.1.2.19 1 rml1p -1 3 dhap 1 3 lald-L 1 3 Methylmalonyl-CoA mutase (MMM2) EC-5.4.99.2 0 succoa -1 3 mmcoa-R 1 3 3-keto-L-gulonate 6-phosphate decarboxylase (KG6PDC) 0 3dgulnp -1 3 h -1 3 co2 1 3 xu5p-L 1 3 L-xylulose 5-phosphate 3-epimerase (X5PL3E) 0 xu5p-L -1 3 ru5p-L 1 3 sorbitol-6-phosphate dehydrogenase (SBTPD) EC-1.1.1.140 1 nad -1 3 sbt6p -1 3 f6p 1 3 h 1 3 nadh 1 3 Taurine dioxygenase (TAUDO) EC-1.14.11.17 0 akg -1 3 o2 -1 3 taur -1 3 aacald 1 3 co2 1 3 h 1 3 so3 1 3 succ 1 3 Propionate kinase (PPAKr) 1 adp -1 3 ppap -1 3 atp 1 3 ppa 1 3 2-Oxobutanoate formate lyase (OBTFL) 0 2obut -1 3 coa -1 3 for 1 3 ppcoa 1 3 alpha,alpha-trehalase (TREHe) EC-3.2.1.28 0 h2o -1 1 tre -1 1 glc-D 2 1 trehalose-6-phosphate hydrolase (TRE6PH) EC-3.2.1.93 0 h2o -1 3 tre6p -1 3 g6p 1 3 glc-D 1 3 alpha,alpha-trehalase (TREH) EC-3.2.1.28 0 h2o -1 3 tre -1 3 glc-D 2 3 L(+)-tartrate dehydratase (TARTD) EC-4.2.1.32 0 tartr-L -1 3 h2o 1 3 oaa 1 3 Phenethylamine oxidase (PEAMNO) EC-1.4.3.6 0 h2o -1 3 o2 -1 3 peamn -1 3 h2o2 1 3 nh4 1 3 pacald 1 3 altronate hydrolase (ALTRH) EC-4.2.1.7 0 altrn -1 3 2ddglcn 1 3 h2o 1 3 tagaturonate reductase (TAGURr) EC-1.1.1.58 1 altrn -1 3 nad -1 3 h 1 3 nadh 1 3 tagur 1 3 glucuronate isomerase (D-glucuronate) (GUI1) EC-5.3.1.12 1 glcur -1 3 fruur 1 3 glucuronate isomerase (D-galacturonate) (GUI2) EC-5.3.1.12 1 galur -1 3 tagur 1 3 D-mannonate hydrolyase (MNNH) EC-4.2.1.8 0 mana -1 3 2ddglcn 1 3 h2o 1 3 Mannonate oxidoreductase (MANAO) EC-1.1.1.57 1 mana -1 3 nad -1 3 fruur 1 3 h 1 3 nadh 1 3 xylose isomerase (XYLI2i) EC-5.3.1.5 0 fru -1 3 glc-D 1 3 xylose isomerase (XYLI1) EC-5.3.1.5 1 xyl-D -1 3 xylu-D 1 3 xylulokinase (XYLK) EC-2.7.1.17 0 atp -1 3 xylu-D -1 3 adp 1 3 h 1 3 xu5p-D 1 3 2,5-diketo-D-gluconate reductase (DKGLCNR1) 0 25dkglcn -1 3 h -1 3 nadph -1 3 2dhguln 1 3 nadp 1 3 Hydroxypyruvate reductase (NADH) (HPYRRx) 0 h -1 3 hpyr -1 3 nadh -1 3 glyc-R 1 3 nad 1 3 Hydroxypyruvate reductase (NADPH) (HPYRRy) 0 h -1 3 hpyr -1 3 nadph -1 3 glyc-R 1 3 nadp 1 3 glucarate dehydratase (GLCRD) EC-4.2.1.40 0 glcr -1 3 5dh4dglc 1 3 h2o 1 3 Methylmalonyl-CoA decarboxylase (MMCD) EC-4.1.1.41 0 h -1 3 mmcoa-S -1 3 co2 1 3 ppcoa 1 3 Propanoyl-CoA: succinate CoA-transferase (PPCSCT) 0 ppcoa -1 3 succ -1 3 ppa 1 3 succoa 1 3 2,5-diketo-D-gluconate reductase (NADPH) (DKGLCNR2y) 0 25dkglcn -1 3 h -1 3 nadph -1 3 5dglcn 1 3 nadp 1 3 2-dehydro-D-gluconate reductase (NADH) (2DGLCNRx) 0 2dhglcn -1 3 h -1 3 nadh -1 3 glcn 1 3 nad 1 3 2-dehydro-D-gluconate reductase (NADPH) (2DGLCNRy) EC-1.1.1.215 0 2dhglcn -1 3 h -1 3 nadph -1 3 glcn 1 3 nadp 1 3 2,5-diketo-D-gluconate reductase (NADH) (DKGLCNR2x) 0 25dkglcn -1 3 h -1 3 nadh -1 3 5dglcn 1 3 nad 1 3 2-dehydro-L-gulonate reductase (NADH) (2DGULRx) 0 2dhguln -1 3 h -1 3 nadh -1 3 idon-L 1 3 nad 1 3 2-dehydro-L-gulonate reductase (NADPH) (2DGULRy) 0 2dhguln -1 3 h -1 3 nadph -1 3 idon-L 1 3 nadp 1 3 2,3 dioxo-L-gulonate reductase (DOGULNR) 0 23doguln -1 3 h -1 3 nadh -1 3 3dhguln 1 3 nad 1 3 Anaplerotic reactions Isocitrate lyase (ICL) EC-4.1.3.1 0 icit -1 3 glx 1 3 succ 1 3 malate synthase (MALS) EC-4.1.3.2 0 accoa -1 3 glx -1 3 h2o -1 3 coa 1 3 h 1 3 mal-L 1 3 malic enzyme (NADP) (ME2) EC-1.1.1.40 0 mal-L -1 3 nadp -1 3 co2 1 3 nadph 1 3 pyr 1 3 phosphoenolpyruvate carboxykinase (PPCK) EC-4.1.1.49 0 atp -1 3 oaa -1 3 adp 1 3 co2 1 3 pep 1 3 inorganic diphosphatase (PPA) EC-3.6.1.1 0 h2o -1 3 ppi -1 3 h 1 3 pi 2 3 phosphoenolpyruvate carboxylase (PPC) EC-4.1.1.31 0 co2 -1 3 h2o -1 3 pep -1 3 h 1 3 oaa 1 3 pi 1 3 malic enzyme (NAD) (ME1) EC-1.1.1.38 0 mal-L -1 3 nad -1 3 co2 1 3 nadh 1 3 pyr 1 3 Arginine and Proline Metabolism 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase (MDRPD) 0 5mdru1p -1 3 dkmpp 1 3 h2o 1 3 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction (DKMPPD2) 0 dkmpp -1 3 h2o -3 3 2kmb 1 3 for 1 3 h 6 3 pi 1 3 Putrescine Transaminase (PTRCTA) 0 akg -1 3 ptrc -1 3 4abutn 1 3 glu-L 1 3 succinate-semialdehyde dehydrogenase (NAD) (SSALx) EC-1.2.1.16 0 h2o -1 3 nad -1 3 sucsal -1 3 h 2 3 nadh 1 3 succ 1 3 Aminobutyraldehyde dehydrogenase (ABUTD) EC-1.2.1.19 0 4abutn -1 3 h2o -1 3 nad -1 3 4abut 1 3 h 2 3 nadh 1 3 5-methylthioribose kinase (MTRK) EC-2.7.1.100 0 5mtr -1 3 atp -1 3 5mdr1p 1 3 adp 1 3 h 1 3 5-methylthioribose-1-phosphate isomerase (MTRI) EC-5.3.1.23 1 5mdr1p -1 3 5mdru1p 1 3 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction (DKMPPD) 0 dkmpp -1 3 h2o -1 3 o2 -1 3 2kmb 1 3 for 1 3 h 2 3 pi 1 3 L-glutamate 5-semialdehyde dehydratase (spontaneous) (G5SADs) 0 glu5sa -1 3 1pyr5c 1 3 h 1 3 h2o 1 3 2-keto-4-methylthiobutyrate transamination (UNK3) 0 2kmb -1 3 glu-L -1 3 akg 1 3 met-L 1 3 N-acetylglutamate synthase (ACGS) EC-2.3.1.1 0 accoa -1 3 glu-L -1 3 acglu 1 3 coa 1 3 h 1 3 acetylglutamate kinase (ACGK) EC-2.7.2.8 0 acglu -1 3 atp -1 3 acg5p 1 3 adp 1 3 N-acetyl-g-glutamyl-phosphate reductase (AGPR) EC-1.2.1.38 1 acg5sa -1 3 nadp -1 3 pi -1 3 acg5p 1 3 h 1 3 nadph 1 3 acetylornithine transaminase (ACOTA) EC-2.6.1.11 1 acorn -1 3 akg -1 3 acg5sa 1 3 glu-L 1 3 N-acetylornithine deacetylase (NACODA) 0 acg5sa -1 3 h2o -1 3 ac 1 3 glu5sa 1 3 acetylornithine deacetylase (ACODA) EC-3.5.1.16 0 acorn -1 3 h2o -1 3 ac 1 3 orn 1 3 argininosuccinate synthase (ARGSS) EC-6.3.4.5 0 asp-L -1 3 atp -1 3 citr-L -1 3 amp 1 3 argsuc 1 3 h 1 3 ppi 1 3 argininosuccinate lyase (ARGSL) EC-4.3.2.1 1 argsuc -1 3 arg-L 1 3 fum 1 3 ornithine carbamoyltransferase (OCBT) EC-2.1.3.3 1 cbp -1 3 orn -1 3 citr-L 1 3 h 1 3 pi 1 3 Arginine succinyltransferase (AST) EC-2.3.1.109 0 arg-L -1 3 succoa -1 3 coa 1 3 h 1 3 sucarg 1 3 Succinylornithine transaminase (SOTA) 0 akg -1 3 sucorn -1 3 glu-L 1 3 sucgsa 1 3 Succinylarginine dihydrolase (SADH) EC-2.6.1.69 0 h -2 3 h2o -2 3 sucarg -1 3 co2 1 3 nh4 2 3 sucorn 1 3 Succinylglutamic semialdehyde dehydrogenase (SGSAD) 0 h2o -1 3 nad -1 3 sucgsa -1 3 h 2 3 nadh 1 3 sucglu 1 3 Succinylglutamate desuccinylase (SGDS) 0 h2o -1 3 sucglu -1 3 glu-L 1 3 succ 1 3 carbamoyl-phosphate synthase (glutamine-hydrolysing) (CBPS) EC-6.3.5.5 0 atp -2 3 gln-L -1 3 h2o -1 3 hco3 -1 3 adp 2 3 cbp 1 3 glu-L 1 3 h 2 3 pi 1 3 succinate-semialdehyde dehydrogenase (NADP) (SSALy) EC-1.2.1.16 0 h2o -1 3 nadp -1 3 sucsal -1 3 h 2 3 nadph 1 3 succ 1 3 4-aminobutyrate transaminase (ABTA) EC-2.6.1.19 0 4abut -1 3 akg -1 3 glu-L 1 3 sucsal 1 3 Glutathionylspermidine amidase (GSPMDA) EC-3.5.1.78 0 gtspmd -1 3 h2o -1 3 gthrd 1 3 spmd 1 3 Glutathionylspermidine synthetase (GSPMDS) EC-6.3.1.8 0 atp -1 3 gthrd -1 3 spmd -1 3 adp 1 3 gtspmd 1 3 h 1 3 pi 1 3 methylthioadenosine nucleosidase (MTAN) EC-3.2.2.16 0 5mta -1 3 h2o -1 3 5mtr 1 3 ade 1 3 glutamate-5-semialdehyde dehydrogenase (G5SD) EC-1.2.1.41 0 glu5p -1 3 h -1 3 nadph -1 3 glu5sa 1 3 nadp 1 3 pi 1 3 glutamate 5-kinase (GLU5K) EC-2.7.2.11 0 atp -1 3 glu-L -1 3 adp 1 3 glu5p 1 3 pyrroline-5-carboxylate reductase (P5CR) EC-1.5.1.2 0 1pyr5c -1 3 h -2 3 nadph -1 3 nadp 1 3 pro-L 1 3 1-pyrroline-5-carboxylate dehydrogenase (P5CD) EC-1.5.1.12 0 1pyr5c -1 3 h2o -2 3 nad -1 3 glu-L 1 3 h 1 3 nadh 1 3 Proline dehydrogenase (PROD2) EC-1.5.99.8 0 fad -1 3 pro-L -1 3 1pyr5c 1 3 fadh2 1 3 h 1 3 arginine decarboxylase (ARGDC) EC-4.1.1.19 0 arg-L -1 3 h -1 3 agm 1 3 co2 1 3 agmatinase (AGMT) EC-3.5.3.11 0 agm -1 3 h2o -1 3 ptrc 1 3 urea 1 3 Ornithine Decarboxylase (ORNDC) EC-4.1.1.17 0 h -1 3 orn -1 3 co2 1 3 ptrc 1 3 Adenosylmethionine decarboxylase (ADMDCr) EC-4.1.1.50 1 amet -1 3 h -1 3 ametam 1 3 co2 1 3 spermidine synthase (SPMS) EC-2.5.1.16 0 ametam -1 3 ptrc -1 3 5mta 1 3 h 1 3 spmd 1 3 Spermidine acetyltransferase (SPMDAT1) EC-2.3.1.57 0 accoa -1 3 spmd -1 3 N1aspmd 1 3 coa 1 3 h 1 3 Spermidine acetyltransferase (N8) (SPMDAT2) EC-2.3.1.57 0 accoa -1 3 spmd -1 3 coa 1 3 h 1 3 n8aspmd 1 3 ornithine transaminase (ORNTA) EC-2.6.1.13 0 akg -1 3 orn -1 3 glu-L 1 3 glu5sa 1 3 Cell Envelope Biosynthesis Peptidoglycan subunit synthesis (PPTGS) 0 uaagmda -1 3 h 1 3 peptido_EC 1 3 udcpdp 1 3 undecaprenyl-diphosphatase (UDCPDP) EC-3.6.1.27 0 h2o -1 3 udcpdp -1 3 h 1 3 pi 1 3 udcpp 1 3 3-deoxy-manno-octulosonate-8-phosphatase (KDOPP) EC-3.1.3.45 0 h2o -1 3 kdo8p -1 3 kdo 1 3 pi 1 3 ethanolamine phosphotransferase (PEPT_EC) EC-2.7.8.1 1 cmp -1 3 h -1 3 pe_EC -0.02 3 12dgr_EC 0.02 3 cdpea 1 3 Phosphatidate phosphatase (PAPA_EC) EC-3.1.3.4 0 h2o -1 3 pa_EC -0.02 3 12dgr_EC 0.02 3 pi 1 3 ECA polymerization (Ecoli) (ECAP_EC) 0 unagamuf -1 3 eca_EC 1 3 h 1 3 udcpdp 1 3 acyl-[acyl-carrier-protein] synthetase (n-C14:0) (AACPS1) EC-6.2.1.20 0 ACP -1 3 atp -1 3 ttdca -1 3 amp 1 3 myrsACP 1 3 ppi 1 3 acyl-[acyl-carrier-protein] synthetase (n-C14:1) (AACPS2) EC-6.2.1.20 0 ACP -1 3 atp -1 3 ttdcea -1 3 amp 1 3 ppi 1 3 tdeACP 1 3 acyl-[acyl-carrier-protein] synthetase (n-C16:0) (AACPS3) EC-6.2.1.20 0 ACP -1 3 atp -1 3 hdca -1 3 amp 1 3 palmACP 1 3 ppi 1 3 acyl-[acyl-carrier-protein] synthetase (n-C16:1) (AACPS4) EC-6.2.1.20 0 ACP -1 3 atp -1 3 hdcea -1 3 amp 1 3 hdeACP 1 3 ppi 1 3 acyl-[acyl-carrier-protein] synthetase (n-C18:1) (AACPS5) EC-6.2.1.20 0 ACP -1 3 atp -1 3 ocdcea -1 3 amp 1 3 octeACP 1 3 ppi 1 3 D-alanine-D-alanine ligase (reversible) (ALAALAr) EC-6.3.2.4 1 ala-D -2 3 atp -1 3 adp 1 3 alaala 1 3 h 1 3 pi 1 3 Diacylglycerol kinase (DAGK_EC) EC-2.7.1.107 0 12dgr_EC -0.02 3 atp -1 3 adp 1 3 h 1 3 pa_EC 0.02 3 Ethanolamine ammonia-lyase (ETHAAL) EC-4.3.1.7 0 etha -1 3 acald 1 3 nh4 1 3 GDP-4-dehydro-6-deoxy-D-mannose epimerase (GDMANE) 0 gdpddman -1 3 gdpofuc 1 3 GDP-4-oxo-L-fucose reductase (GOFUCR) 0 gdpofuc -1 3 h -1 3 nadph -1 3 gdpfuc 1 3 nadp 1 3 UTP-glucose-1-phosphate uridylyltransferase (irreversible) (GALUi) EC-2.7.7.9 0 g1p -1 3 h -1 3 utp -1 3 ppi 1 3 udpg 1 3 UDPgalactopyranose mutase (UDPGALM) EC-5.4.99.9 0 udpgal -1 3 udpgalfur 1 3 glutamine-fructose-6-phosphate transaminase (GF6PTA) EC-2.6.1.16 0 f6p -1 3 gln-L -1 3 gam6p 1 3 glu-L 1 3 UDP-N-acetylglucosamine diphosphorylase (UAGDP) EC-2.7.7.23 0 acgam1p -1 3 h -1 3 utp -1 3 ppi 1 3 uacgam 1 3 glucosamine-1-phosphate N-acetyltransferase (G1PACT) EC-2.3.1.157 0 accoa -1 3 gam1p -1 3 acgam1p 1 3 coa 1 3 h 1 3 Glycerophosphodiester phosphodiesterase (Glycerophosphocholine) (GPDDA1) EC-3.1.4.46 0 g3pc -1 3 h2o -1 3 chol 1 3 glyc3p 1 3 h 1 3 Glycerophosphodiester phosphodiesterase (Glycerophosphoethanolamine) (GPDDA2) EC-3.1.4.46 0 g3pe -1 3 h2o -1 3 etha 1 3 glyc3p 1 3 h 1 3 Glycerophosphodiester phosphodiesterase (Glycerophosphoserine) (GPDDA3) EC-3.1.4.46 0 g3ps -1 3 h2o -1 3 glyc3p 1 3 h 1 3 ser-L 1 3 Glycerophosphodiester phosphodiesterase (Glycerophosphoglycerol) (GPDDA4) EC-3.1.4.46 0 g3pg -1 3 h2o -1 3 glyc 1 3 glyc3p 1 3 h 1 3 Glycerophosphodiester phosphodiesterase (Glycerophosphoinositol) (GPDDA5) EC-3.1.4.46 0 g3pi -1 3 h2o -1 3 glyc3p 1 3 h 1 3 inost 1 3 GDP-D-mannose dehydratase (GMAND) EC-4.2.1.47 0 gdpmann -1 3 gdpddman 1 3 h2o 1 3 sedoheptulose 7-phosphate isomerase (S7PI) 0 s7p -1 3 gmhep7p 1 3 D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase (GMHEPPA) 0 gmhep17bp -1 3 h2o -1 3 gmhep1p 1 3 pi 1 3 3-deoxy -D-manno-octulosonic -acid 8-phosphate (KDOPS) EC-4.1.2.16 0 ara5p -1 3 h2o -1 3 pep -1 3 kdo8p 1 3 pi 1 3 3-deoxy-manno-octulosonate cytidylyltransferase (KDOCT2) EC-2.7.7.38 0 ctp -1 3 kdo -1 3 ckdo 1 3 ppi 1 3 3-deoxy-D-manno-octulosonic acid transferase (MOAT) 0 ckdo -1 3 lipidA -1 3 cmp 1 3 h 1 3 kdolipid4 1 3 3-deoxy-D-manno-octulosonic acid transferase (MOAT2) 0 ckdo -1 3 kdolipid4 -1 3 cmp 1 3 h 1 3 kdo2lipid4 1 3 UDP-N-acetylglucosamine acyltransferase (UAGAAT) EC-2.3.1.129 1 3hmrsACP -1 3 uacgam -1 3 ACP 1 3 u3aga 1 3 Lipid A disaccaride synthase (LPADSS) EC-2.4.1.182 0 lipidX -1 3 u23ga -1 3 h 1 3 lipidAds 1 3 udp 1 3 UDP-3-O-acetylglucosamine deacetylase (UHGADA) 0 h2o -1 3 u3aga -1 3 ac 1 3 u3hga 1 3 UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase (U23GAAT) 0 3hmrsACP -1 3 u3hga -1 3 ACP 1 3 h 1 3 u23ga 1 3 Tetraacyldisaccharide 4'kinase (TDSK) EC-2.7.1.130 0 atp -1 3 lipidAds -1 3 adp 1 3 h 1 3 lipidA 1 3 Endotoxin Synthesis (lauroyl transferase) (EDTXS1) 0 ddcaACP -1 3 kdo2lipid4 -1 3 ACP 1 3 kdo2lipid4L 1 3 Endotoxin Synthesis (palmitoleoyl ACP) (EDTXS3) 0 hdeACP -1 3 kdo2lipid4 -1 3 ACP 1 3 kdo2lipid4p 1 3 mannose-1-phosphate guanylyltransferase (GDP) (MAN1PT2) EC-2.7.7.22 0 gdp -1 3 h -1 3 man1p -1 3 gdpmann 1 3 pi 1 3 phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate) (PAPPT3) EC-2.7.8.13 0 udcpp -1 3 ugmda -1 3 uagmda 1 3 ump 1 3 phosphoglucosamine mutase (PGAMT) EC-5.4.2.10 1 gam1p -1 3 gam6p 1 3 Endotoxin Synthesis (myristoyl transferase) (EDTXS4) 0 kdo2lipid4p -1 3 myrsACP -1 3 ACP 1 3 lipa_cold 1 3 Endotoxin Synthesis (myristoyl transferase) (EDTXS2) 0 kdo2lipid4L -1 3 myrsACP -1 3 ACP 1 3 lipa 1 3 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (UAGCVT) EC-2.5.1.7 0 pep -1 3 uacgam -1 3 pi 1 3 uaccg 1 3 UDP-N-acetylenolpyruvoylglucosamine reductase (UAPGR) EC-1.1.1.158 0 h -1 3 nadph -1 3 uaccg -1 3 nadp 1 3 uamr 1 3 UDP-N-acetylmuramoyl-L-alanine synthetase (UAMAS) EC-6.3.2.8 0 ala-L -1 3 atp -1 3 uamr -1 3 adp 1 3 h 1 3 pi 1 3 uama 1 3 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase (UAMAGS) EC-6.3.2.9 0 atp -1 3 glu-D -1 3 uama -1 3 adp 1 3 h 1 3 pi 1 3 uamag 1 3 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase (UAAGDS) EC-6.3.2.13 0 26dap-M -1 3 atp -1 3 uamag -1 3 adp 1 3 h 1 3 pi 1 3 ugmd 1 3 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase (UGMDDS) EC-6.3.2.15 0 alaala -1 3 atp -1 3 ugmd -1 3 adp 1 3 h 1 3 pi 1 3 ugmda 1 3 UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (UAGPT3) 0 uacgam -1 3 uagmda -1 3 h 1 3 uaagmda 1 3 udp 1 3 glutamate racemase (GLUR) EC-5.1.1.3 1 glu-D -1 3 glu-L 1 3 Phospholipase A (phosphatidylcholine) (PLIPA3) 0 h2o -1 3 pc_EC -0.02 3 agpc_EC 0.02 3 h 1 3 hdca 0.36 3 hdcea 0.07 3 ocdcea 0.5 3 ttdca 0.02 3 ttdcea 0.05 3 Phospholipase A (phosphatidylglycerol) (PLIPA1) 0 h2o -1 3 pg_EC -0.02 3 agpg_EC 0.02 3 h 1 3 hdca 0.36 3 hdcea 0.07 3 ocdcea 0.5 3 ttdca 0.02 3 ttdcea 0.05 3 Phosphlipase A (phosphatidylethanolamine) (PLIPA2) 0 h2o -1 3 pe_EC -0.02 3 agpe_EC 0.02 3 h 1 3 hdca 0.36 3 hdcea 0.07 3 ocdcea 0.5 3 ttdca 0.02 3 ttdcea 0.05 3 Lysophospholipase L (acyl-glycerophosphoglycerol) (LPLIPA1) 0 agpg_EC -0.02 3 h2o -1 3 g3pg 1 3 h 1 3 hdca 0.36 3 hdcea 0.07 3 ocdcea 0.5 3 ttdca 0.02 3 ttdcea 0.05 3 Lysophospholipase L (acyl-glycerophosphoethanolamine) (LPLIPA2) 0 agpe_EC -0.02 3 h2o -1 3 g3pe 1 3 h 1 3 hdca 0.36 3 hdcea 0.07 3 ocdcea 0.5 3 ttdca 0.02 3 ttdcea 0.05 3 Lysophospholipase L (acyl-glycerophosphocholinel) (LPLIPA3) 0 agpc_EC -0.02 3 h2o -1 3 g3pc 1 3 h 1 3 hdca 0.36 3 hdcea 0.07 3 ocdcea 0.5 3 ttdca 0.02 3 ttdcea 0.05 3 Lysophospholipase L (acyl transfer to phosphatidylglycerol) (LPLIPA4) 0 agpe_EC -0.02 3 pg_EC -0.02 3 apg_EC 0.02 3 g3pe 1 3 Lysophospholipase L (acyl transfer to phosphatidylglycerol) (LPLIPA5) 0 agpc_EC -0.02 3 pg_EC -0.02 3 apg_EC 0.02 3 g3pc 1 3 Lysophospholipase L (acyl transfer to phosphatidylglycerol) (LPLIPA6) 0 agpg_EC -0.02 3 pg_EC -0.02 3 apg_EC 0.02 3 g3pg 1 3 ADP-D-glycero-D-manno-heptose epimerase (AGMHE) EC-5.1.3.20 0 adphep-D,D -1 3 adphep-L,D 1 3 D-glycero-D-manno-hepose 1-phosphate adenyltransferase (GMHEPAT) 0 atp -1 3 gmhep1p -1 3 h -1 3 adphep-D,D 1 3 ppi 1 3 D-glycero-D-manno-heptose 7-phosphate kinase (GMHEPK) 0 atp -1 3 gmhep7p -1 3 adp 1 3 gmhep17bp 1 3 h 1 3 Lipopolysaccharide synthesis (Ecoli) (LPSSYN_EC) 0 adphep-L,D -3 3 cdpea -2 3 ckdo -3 3 lipa -1 3 udpg -2 3 adp 3 3 cdp 2 3 cmp 3 3 h 10 3 lps_EC 1 3 udp 2 3 glucose-1-phosphate thymidylyltransferase (G1PTT) EC-2.7.7.24 0 dttp -1 3 g1p -1 3 h -1 3 dtdpglu 1 3 ppi 1 3 dTDPglucose 4,6-dehydratase (TDPGDH) EC-4.2.1.46 0 dtdpglu -1 3 dtdp4d6dg 1 3 h2o 1 3 dTDP-4-dehydrorhamnose 3,5-epimerase (TDPDRE) EC-5.1.3.13 0 dtdp4d6dg -1 3 dtdp4d6dm 1 3 dTDP-4-dehydrorhamnose reductase (TDPDRR) EC-1.1.1.133 0 dtdp4d6dm -1 3 h -1 3 nadph -1 3 dtdprmn 1 3 nadp 1 3 myo-inositol 1-phosphatase (MI1PP) EC-3.1.3.25 0 h2o -1 3 mi1p-D -1 3 inost 1 3 pi 1 3 UDPglucose 6-dehydrogenase (UDPGD) EC-1.1.1.22 0 h2o -1 3 nad -2 3 udpg -1 3 h 3 3 nadh 2 3 udpglcur 1 3 UDP-sugar hydrolase (USHD) 0 h2o -1 3 u23ga -1 3 h 2 3 lipidX 1 3 ump 1 3 UDP-N-acetylglucosamine:undecaprenylphosphate N-acetylglucosamine -1-phosphate transferase (ACGAMT) 0 uacgam -1 3 udcpp -1 3 ump 1 3 unaga 1 3 UDP-N-acetylglucosamine 2-epimerase (UAG2Ei) EC-5.1.3.14 0 uacgam -1 3 uacmam 1 3 UDP-N-acetyl-D-mannosamine oxidoreductase (UACMAMO) 0 h2o -1 3 nad -2 3 uacmam -1 3 h 3 3 nadh 2 3 uacmamu 1 3 dTDP-4-amino-4,6-dideoxy-D-glucose acetyltransferase (TDPADGAT) 0 accoa -1 3 dtdp4addg -1 3 coa 1 3 dtdp4aaddg 1 3 h 1 3 dTDP-4-amino-4,6-dideoxy-D-glucose transaminase (TDPAGTA) EC-2.6.1.33 0 dtdp4d6dg -1 3 glu-L -1 3 akg 1 3 dtdp4addg 1 3 dTDP-N-4-acetamido-4,6-dideoxy-D-galactose transferase (AADDGT) 0 dtdp4aaddg -1 3 unagamu -1 3 dtdp 1 3 h 1 3 unagamuf 1 3 UDP-N-acetyl-D-mannosaminuronic acid transferase (ACMAMUT) 0 uacmamu -1 3 unaga -1 3 h 1 3 udp 1 3 unagamu 1 3 Citrate Cycle (TCA) aconitase (ACONT) EC-4.2.1.3 1 cit -1 3 icit 1 3 Citrate lyase (CITL) EC-4.1.3.6 0 cit -1 3 ac 1 3 oaa 1 3 fumarate reductase (FRD2) EC-1.3.99.1 0 fum -1 3 mql8 -1 3 mqn8 1 3 succ 1 3 fumarate reductase (FRD3) EC-1.3.99.1 0 2dmmql8 -1 3 fum -1 3 2dmmq8 1 3 succ 1 3 fumarase (FUM) EC-4.2.1.2 1 fum -1 3 h2o -1 3 mal-L 1 3 citrate synthase (CS) EC-4.1.3.7 0 accoa -1 3 h2o -1 3 oaa -1 3 cit 1 3 coa 1 3 h 1 3 isocitrate dehydrogenase (NADP) (ICDHyr) EC-1.1.1.42 1 icit -1 3 nadp -1 3 akg 1 3 co2 1 3 nadph 1 3 2-Oxogluterate dehydrogenase (TEST_AKGDH) EC-Undetermined 0 akg -1 3 coa -1 3 nad -1 3 co2 1 3 nadh 1 3 succoa 1 3 malate dehydrogenase (MDH) EC-1.1.1.37 1 mal-L -1 3 nad -1 3 h 1 3 nadh 1 3 oaa 1 3 Malate dehydrogenase (ubiquinone 8 as acceptor) (MDH2) EC-1.1.99.16 0 mal-L -1 3 q8 -1 3 oaa 1 3 q8h2 1 3 Malate dehydrogenase (menaquinone 8 as acceptor) (MDH3) EC-1.1.99.16 0 mal-L -1 3 mqn8 -1 3 mql8 1 3 oaa 1 3 succinate dehydrogenase (SUCD1i) EC-1.3.99.1 0 fad -1 3 succ -1 3 fadh2 1 3 fum 1 3 succinyl-CoA synthetase (ADP-forming) (SUCOAS) EC-6.2.1.5 1 atp -1 3 coa -1 3 succ -1 3 adp 1 3 pi 1 3 succoa 1 3 Cofactor and Prosthetic Group Biosynthesis pyrimidine phosphatase (PMDPHT) 0 5aprbu -1 3 h2o -1 3 4r5au 1 3 pi 1 3 Dihydroneopterin monophosphate dephosphorylase (DNMPPA) 0 dhpmp -1 3 h2o -1 3 dhnpt 1 3 pi 1 3 NADP phosphatase (NADPPPS) 0 h2o -1 3 nadp -1 3 nad 1 3 pi 1 3 NMN nucleosidase (NMNN) EC-3.2.2.14 0 h2o -1 3 nmn -1 3 h 1 3 ncam 1 3 r5p 1 3 NAD diphosphatase (extracellular) (NADDPe) EC-3.6.1.22 0 h2o -1 1 nad -1 1 amp 1 1 h 2 1 nmn 1 1 phosphopantothenoylcysteine decarboxylase (PPCDC) EC-4.1.1.36 0 4ppcys -1 3 h -1 3 co2 1 3 pan4p 1 3 dephospho-CoA kinase (DPCOAK) EC-2.7.1.24 0 atp -1 3 dpcoa -1 3 adp 1 3 coa 1 3 h 1 3 hypothetical enyme (HYPOE) 0 h2o -1 3 pyam5p -1 3 pi 1 3 pydam 1 3 Pyridoxal 5-phosphate phosphatase (PYDXPP) 0 h2o -1 3 pydx5p -1 3 pi 1 3 pydx 1 3 Pyridoxine 5-phosphate phosphatase (PDXPP) 0 h2o -1 3 pdx5p -1 3 pi 1 3 pydxn 1 3 nicotinamide-nucleotide amidase (NMNDA) EC-3.5.1.42 0 h2o -1 3 nmn -1 3 nh4 1 3 nicrnt 1 3 thiamine kinase (TMKr) EC-2.7.1.89 1 atp -1 3 thm -1 3 adp 1 3 h 1 3 thmmp 1 3 phosphopantothenate-cysteine ligase (PPNCL2) EC-6.3.2.5 0 4ppan -1 3 ctp -1 3 cys-L -1 3 4ppcys 1 3 cmp 1 3 h 1 3 ppi 1 3 acyl-carrier protein synthase (ACPS1) EC-2.7.8.7 0 apoACP -1 3 coa -1 3 ACP 1 3 h 1 3 pap 1 3 adenosylmethionine-8-amino-7-oxononanoate transaminase (AMAOTr) EC-2.6.1.62 1 8aonn -1 3 amet -1 3 amob 1 3 dann 1 3 biotin synthase (ala-L producing) (BTS2) 1 cys-L -1 3 dtbt -1 3 ala-L 1 3 btn 1 3 h 2 3 dethiobiotin synthase (DBTSr) EC-6.3.3.3 1 atp -1 3 co2 -1 3 dann -1 3 adp 1 3 dtbt 1 3 h 3 3 pi 1 3 8-amino-7-oxononanoate synthase (AOXSr) EC-2.3.1.47 1 ala-L -1 3 h -1 3 pmcoa -1 3 8aonn 1 3 co2 1 3 coa 1 3 Biotin sulfoxide reductase (BSORx) 0 btnso -1 3 h -1 3 nadh -1 3 btn 1 3 h2o 1 3 nad 1 3 Biotin sulfoxide reductase (BSORy) 0 btnso -1 3 h -1 3 nadph -1 3 btn 1 3 h2o 1 3 nadp 1 3 Cobinamide adenyltransferase (CBIAT) 1 atp -1 3 cbi -1 3 h2o -1 3 adocbi 1 3 pi 1 3 ppi 1 3 cob(I)alamin adenosyltransferase (CBLAT) EC-2.5.1.17 1 atp -1 3 cbl1 -1 3 h2o -1 3 adocbl 1 3 pi 1 3 ppi 1 3 pantothenate kinase (PNTK) EC-2.7.1.33 0 atp -1 3 pnto-R -1 3 4ppan 1 3 adp 1 3 h 1 3 pantetheine-phosphate adenylyltransferase (PTPATi) EC-2.7.7.3 0 atp -1 3 h -1 3 pan4p -1 3 dpcoa 1 3 ppi 1 3 Adenosylcobalamin 5'-phosphate synthase (ADOCBLS) 0 agdpcbi -1 3 rdmbzi -1 3 adocbl 1 3 gmp 1 3 h 1 3 Nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase (NNDMBRT) 0 dmbzid -1 3 nicrnt -1 3 5prdmbz 1 3 h 1 3 nac 1 3 Adenosyl cobinamide kinase (ADOCBIK) 0 adocbi -1 3 atp -1 3 adocbip 1 3 adp 1 3 h 1 3 Adenosyl cobinamide phosphate guanyltransferase (ACBIPGT) 0 adocbip -1 3 gtp -1 3 h -1 3 agdpcbi 1 3 ppi 1 3 Heme O synthase (HEMEOS) 0 frdp -1 3 h2o -1 3 pheme -1 3 hemeO 1 3 ppi 1 3 sirohydrochlorin dehydrogenase (NAD) (SHCHD2) 0 nad -1 3 shcl -1 3 h 1 3 nadh 1 3 srch 1 3 sirohydrochlorin ferrochetalase (SHCHF) 0 fe2 -1 3 srch -1 3 h 3 3 sheme 1 3 1-deoxy-D-xylulose reductoisomerase (DXPRIi) 0 dxyl5p -1 3 h -1 3 nadph -1 3 2me4p 1 3 nadp 1 3 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) 0 g3p -1 3 h -1 3 pyr -1 3 co2 1 3 dxyl5p 1 3 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (DHBD) EC-1.3.1.28 1 23ddhb -1 3 nad -1 3 23dhb 1 3 h 1 3 nadh 1 3 isochorismatase (ICHORT) EC-3.3.2.1 0 h2o -1 3 ichor -1 3 23ddhb 1 3 pyr 1 3 enterochelin synthase (ENTCS) 0 23dhba -3 3 seramp -3 3 amp 6 3 enter 1 3 h 6 3 2,3-dihydroxybenzoate adenylate synthase (DHBSr) EC-2.7.7.58 1 23dhb -1 3 atp -1 3 23dhba 1 3 ppi 1 3 (L-seryl)adenylate synthase (SERASr) 1 atp -1 3 h -1 3 ser-L -1 3 ppi 1 3 seramp 1 3 Erythrose 4-phosphate dehydrogenase (E4PD) 1 e4p -1 3 h2o -1 3 nad -1 3 4per 1 3 h 2 3 nadh 1 3 dihydrofolate reductase (DHFR) EC-1.5.1.3 1 dhf -1 3 h -1 3 nadph -1 3 nadp 1 3 thf 1 3 dihydroneopterin aldolase (DHNPA2) 0 dhnpt -1 3 6hmhpt 1 3 gcald 1 3 dihydrofolate synthase (DHFS) EC-6.3.2.12 0 atp -1 3 dhpt -1 3 glu-L -1 3 adp 1 3 dhf 1 3 pi 1 3 GTP cyclohydrolase I (GTPCI) EC-3.5.4.16 0 gtp -1 3 h2o -1 3 ahdt 1 3 for 1 3 6-hydroxymethyl-dihydropterin pyrophosphokinase (HPPK2) 0 6hmhpt -1 3 atp -1 3 6hmhptpp 1 3 amp 1 3 h 1 3 dihydropteroate synthase (DHPS2) 0 4abz -1 3 6hmhptpp -1 3 dhpt 1 3 h 1 3 ppi 1 3 2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase (MECDPDH) 0 2mecdp -1 3 h -1 3 h2mb4p 1 3 h2o 1 3 Glutamyl-tRNA synthetase (GLUTRS) EC-6.1.1.17 0 atp -1 3 glu-L -1 3 trnaglu -1 3 amp 1 3 glutrna 1 3 ppi 1 3 D-alanine transaminase (ALATA_D2) 0 ala-D -1 3 pydx5p -1 3 pyam5p 1 3 pyr 1 3 alanine transaminase (ALATA_L2) 0 ala-L -1 3 pydx5p -1 3 pyam5p 1 3 pyr 1 3 glutathione oxidoreductase (GTHOr) EC-1.6.4.2 1 gthox -1 3 h -1 3 nadph -1 3 gthrd 2 3 nadp 1 3 gamma-glutamylcysteine synthetase (GLUCYS) EC-6.3.2.2 0 atp -1 3 cys-L -1 3 glu-L -1 3 adp 1 3 glucys 1 3 h 1 3 pi 1 3 glutathione synthetase (GTHS) EC-6.3.2.3 0 atp -1 3 glucys -1 3 gly -1 3 adp 1 3 gthrd 1 3 h 1 3 pi 1 3 glutamyl-tRNA reductase (GLUTRR) 0 glutrna -1 3 h -1 3 nadph -1 3 glu1sa 1 3 nadp 1 3 trnaglu 1 3 porphobilinogen synthase (PPBNGS) EC-4.2.1.24 0 5aop -2 3 h 1 3 h2o 2 3 ppbng 1 3 hydroxymethylbilane synthase (HMBS) EC-4.3.1.8 0 h2o -1 3 ppbng -4 3 hmbil 1 3 nh4 4 3 uroporphyrinogen-III synthase (UPP3S) EC-4.2.1.75 0 hmbil -1 3 h2o 1 3 uppg3 1 3 uroporphyrinogen decarboxylase (uroporphyrinogen III) (UPPDC1) EC-4.1.1.37 0 h -4 3 uppg3 -1 3 co2 4 3 cpppg3 1 3 coproporphyrinogen oxidase (O2 required) (CPPPGO) EC-1.3.3.3 0 cpppg3 -1 3 h -2 3 o2 -1 3 co2 2 3 h2o 2 3 pppg9 1 3 protoporphyrinogen oxidase (PPPGO) EC-1.3.3.4 0 o2 -1.5 3 pppg9 -1 3 h2o 3 3 ppp9 1 3 Ferrochelatase (FCLT) EC-4.99.1.1 0 fe2 -1 3 ppp9 -1 3 h 2 3 pheme 1 3 glutamate-1-semialdehyde aminotransferase (G1SATi) EC-5.4.3.8 0 glu1sa -1 3 5aop 1 3 uroporphyrinogen methyltransferase (UPP3MT) EC-2.1.1.107 0 amet -2 3 uppg3 -1 3 ahcys 2 3 h 1 3 shcl 1 3 isopentenyl-diphosphate D-isomerase (IPDDIi) EC-5.3.3.2 0 ipdp -1 3 dmpp 1 3 dimethylallyltranstransferase (DMATT) EC-2.5.1.1 0 dmpp -1 3 ipdp -1 3 grdp 1 3 ppi 1 3 geranyltranstransferase (GRTT) EC-2.5.1.10 0 grdp -1 3 ipdp -1 3 frdp 1 3 ppi 1 3 Octaprenyl pyrophosphate synthase (OCTDPS) 0 frdp -1 3 ipdp -5 3 octdp 1 3 ppi 5 3 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (MEPCT) 0 2me4p -1 3 ctp -1 3 h -1 3 4c2me 1 3 ppi 1 3 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (CDPMEK) 0 4c2me -1 3 atp -1 3 2p4c2me 1 3 adp 1 3 h 1 3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECDPS) 0 2p4c2me -1 3 2mecdp 1 3 cmp 1 3 NAD diphosphatase (NADDP) EC-3.6.1.22 0 h2o -1 3 nad -1 3 amp 1 3 h 2 3 nmn 1 3 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp) (DMPPS) 0 h -1 3 h2mb4p -1 3 nadh -1 3 dmpp 1 3 h2o 1 3 nad 1 3 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp) (IPDPS) 0 h -1 3 h2mb4p -1 3 nadh -1 3 h2o 1 3 ipdp 1 3 nad 1 3 1,4-dihydroxy-2-naphthoate octaprenyltransferase (DHNAOT) 0 dhna -1 3 octdp -1 3 2dmmq8 1 3 co2 1 3 h 1 3 ppi 1 3 naphthoate synthase (NPHS) EC-4.1.3.36 0 sbzcoa -1 3 coa 1 3 dhna 1 3 O-succinylbenzoate-CoA synthase (SUCBZS) 0 2shchc -1 3 h2o 1 3 sucbz 1 3 2-oxoglutarate decarboxylase (OXGDC2) EC-4.1.1.71 0 akg -1 3 h -1 3 thmpp -1 3 co2 1 3 ssaltpp 1 3 2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylate synthase (SHCHCS2) 0 ichor -1 3 ssaltpp -1 3 2shchc 1 3 pyr 1 3 thmpp 1 3 o-succinylbenzoate-CoA ligase (SUCBZL) EC-6.2.1.26 0 atp -1 3 coa -1 3 sucbz -1 3 amp 1 3 ppi 1 3 sbzcoa 1 3 Isochorismate Synthase (ICHORSi) 0 chor -1 3 ichor 1 3 S-adenosylmethione:2-demethylmenaquinone methyltransferase (AMMQT8_2) 0 2dmmq8 -1 3 amet -1 3 ahcys 1 3 h 1 3 mqn8 1 3 quinolinate synthase (QULNS) 0 dhap -1 3 iasp -1 3 h 1 3 h2o 2 3 pi 1 3 quln 1 3 L-aspartate oxidase (ASPO3) 0 asp-L -1 3 q8 -1 3 iasp 1 3 q8h2 1 3 L-aspartate oxidase (ASPO4) 0 asp-L -1 3 mqn8 -1 3 iasp 1 3 mql8 1 3 L-aspartate oxidase (ASPO5) 0 asp-L -1 3 fum -1 3 iasp 1 3 succ 1 3 L-aspartate oxidase (ASPO6) 0 asp-L -1 3 o2 -1 3 h2o2 1 3 iasp 1 3 nicotinate-nucleotide diphosphorylase (carboxylating) (NNDPR) EC-2.4.2.19 0 h -2 3 prpp -1 3 quln -1 3 co2 1 3 nicrnt 1 3 ppi 1 3 nicotinate-nucleotide adenylyltransferase (NNAT) EC-2.7.7.18 0 atp -1 3 h -1 3 nicrnt -1 3 dnad 1 3 ppi 1 3 nicotinamide-nucleotide adenylyltransferase (NMNAT) EC-2.7.7.1 0 atp -1 3 h -1 3 nmn -1 3 nad 1 3 ppi 1 3 NAD synthase (nh3) (NADS1) EC-6.3.1.5 0 atp -1 3 dnad -1 3 nh4 -1 3 amp 1 3 h 1 3 nad 1 3 ppi 1 3 Dihydroneopterin triphosphate pyrophosphatase (DNTPPA) 0 ahdt -1 3 h2o -1 3 dhpmp 1 3 h 1 3 ppi 1 3 4-amino-4-deoxychorismate synthase (ADCS) 0 chor -1 3 gln-L -1 3 4adcho 1 3 glu-L 1 3 4-aminobenzoate synthase (ADCL) 0 4adcho -1 3 4abz 1 3 h 1 3 pyr 1 3 3-methyl-2-oxobutanoate hydroxymethyltransferase (MOHMT) EC-2.1.2.11 0 3mob -1 3 h2o -1 3 mlthf -1 3 2dhp 1 3 thf 1 3 pantothenate synthase (PANTS) EC-6.3.2.1 0 ala-B -1 3 atp -1 3 pant-R -1 3 amp 1 3 h 1 3 pnto-R 1 3 ppi 1 3 aspartate 1-decarboxylase (ASP1DC) EC-4.1.1.11 0 asp-L -1 3 h -1 3 ala-B 1 3 co2 1 3 2-dehydropantoate 2-reductase (DPR) EC-1.1.1.169 0 2dhp -1 3 h -1 3 nadph -1 3 nadp 1 3 pant-R 1 3 Pyridoxine 5'-phosphate synthase (PDX5PS) 0 dxyl5p -1 3 nad -1 3 phthr -1 3 co2 1 3 h 1 3 h2o 2 3 nadh 1 3 pdx5p 1 3 pi 1 3 Erythronate 4-phosphate (4per) dehydrogenase (PERD) 1 4per -1 3 nad -1 3 h 1 3 nadh 1 3 ohpb 1 3 pyridoxine 5'-phosphate oxidase (PDX5PO) EC-1.4.3.5 1 o2 -1 3 pdx5p -1 3 h2o2 1 3 pydx5p 1 3 pyridoxamine 5'-phosphate oxidase (PYAM5PO) EC-1.4.3.5 0 h2o -1 3 o2 -1 3 pyam5p -1 3 h2o2 1 3 nh4 1 3 pydx5p 1 3 pyridoxine kinase (PYDXNK) EC-2.7.1.35 0 atp -1 3 pydxn -1 3 adp 1 3 h 1 3 pdx5p 1 3 pyridoxamine kinase (PYDAMK) EC-2.7.1.35 0 atp -1 3 pydam -1 3 adp 1 3 h 1 3 pyam5p 1 3 pyridoxal kinase (PYDXK) EC-2.7.1.35 0 atp -1 3 pydx -1 3 adp 1 3 h 1 3 pydx5p 1 3 alpha-ribazole 5-phosphate phosphatase (RZ5PP) 0 5prdmbz -1 3 h2o -1 3 pi 1 3 rdmbzi 1 3 nicotinamidase (NNAM) EC-3.5.1.19 0 h2o -1 3 ncam -1 3 nac 1 3 nh4 1 3 nicotinic acid mononucleotide pyrophosphorylase (NAMNPP) 0 atp -1 3 h2o -1 3 nac -1 3 prpp -1 3 adp 1 3 nicrnt 1 3 pi 1 3 ppi 1 3 GTP cyclohydrolase II (25drapp) (GTPCII2) 0 gtp -1 3 h2o -3 3 25drapp 1 3 for 1 3 h 2 3 ppi 1 3 3,4-Dihydroxy-2-butanone-4-phosphate (DB4PS) 0 ru5p-D -1 3 db4p 1 3 for 1 3 h 1 3 5-amino-6-(5-phosphoribosylamino)uracil reductase (APRAUR) EC-1.1.1.193 0 5apru -1 3 h -1 3 nadph -1 3 5aprbu 1 3 nadp 1 3 diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp) (DHPPDA2) EC-3.5.4.26 0 25drapp -1 3 h -1 3 h2o -1 3 5apru 1 3 nh4 1 3 riboflavin synthase (RBFSa) EC-2.5.1.9 0 4r5au -1 3 db4p -1 3 dmlz 1 3 h2o 2 3 pi 1 3 riboflavin kinase (RBFK) EC-2.7.1.26 0 atp -1 3 ribflv -1 3 adp 1 3 fmn 1 3 h 1 3 FMN adenylyltransferase (FMNAT) EC-2.7.7.2 0 atp -1 3 fmn -1 3 h -1 3 fad 1 3 ppi 1 3 riboflavin synthase (RBFSb) EC-2.5.1.9 0 dmlz -2 3 4r5au 1 3 ribflv 1 3 O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase (OHPBAT) EC-2.6.1.52 1 glu-L -1 3 ohpb -1 3 akg 1 3 phthr 1 3 4-amino-2-methyl-5-phosphomethylpyrimidine synthetase (AMPMS) 0 air -1 3 h2o -1 3 4ampm 1 3 for 2 3 h 4 3 phosphomethylpyrimidine kinase (PMPK) EC-2.7.4.7 0 4ampm -1 3 atp -1 3 2mahmp 1 3 adp 1 3 hydroxymethylpyrimidine kinase (ATP) (HMPK1) EC-2.7.1.49 0 4ahmmp -1 3 atp -1 3 4ampm 1 3 adp 1 3 h 1 3 thiamine-phosphate diphosphorylase (TMPPP) EC-2.5.1.3 0 2mahmp -1 3 4mpetz -1 3 h -1 3 ppi 1 3 thmmp 1 3 thiamine-phosphate kinase (TMPKr) EC-2.7.4.16 1 atp -1 3 thmmp -1 3 adp 1 3 thmpp 1 3 hydroxyethylthiazole kinase (HETZK) EC-2.7.1.50 0 4mhetz -1 3 atp -1 3 4mpetz 1 3 adp 1 3 h 1 3 thiazole phosphate synthesis (THZPSN) 0 atp -1 3 cys-L -1 3 dxyl5p -1 3 tyr-L -1 3 4hba 1 3 4mpetz 1 3 ala-L 1 3 amp 1 3 co2 1 3 h 1 3 h2o 1 3 ppi 1 3 4-Hydroxy-L-threonine synthase (4HTHRS) 0 h2o -1 3 phthr -1 3 4hthr 1 3 pi 1 3 Hydroxybenzoate octaprenyltransferase (HBZOPT) 0 4hbz -1 3 octdp -1 3 3ophb 1 3 ppi 1 3 2-Octaprenylphenol hydroxylase (OPHHX) 0 2oph -1 3 o2 -0.5 3 2ohph 1 3 Chorismate pyruvate lyase (CHRPL) 0 chor -1 3 4hbz 1 3 pyr 1 3 Octaprenyl-hydroxybenzoate decarboxylase (OPHBDC) 0 3ophb -1 3 h -1 3 2oph 1 3 co2 1 3 2-Octaprenyl-6-methoxy-benzoquinol methylase (OMBZLM) 0 2ombzl -1 3 amet -1 3 2ommbl 1 3 ahcys 1 3 h 1 3 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (OMMBLHX) 0 2ommbl -1 3 o2 -0.5 3 2omhmbl 1 3 2-octaprenyl-6-hydroxyphenol methylase (OHPHM) 0 2ohph -1 3 amet -1 3 2omph 1 3 ahcys 1 3 h 1 3 3-Dimethylubiquinonol 3-methyltransferase (DMQMT) 0 2omhmbl -1 3 amet -1 3 ahcys 1 3 h 1 3 q8h2 1 3 2-octaprenyl-6-methoxyphenol hydroxylase (OMPHHX) 0 2omph -1 3 o2 -0.5 3 2ombzl 1 3 Undecaprenyl diphosphate synthase (UDCPDPS) 0 frdp -1 3 ipdp -8 3 ppi 8 3 udcpdp 1 3 1-Deoxy-D-xylulose kinase (DXYLK) 0 atp -1 3 dxyl -1 3 adp 1 3 dxyl5p 1 3 h 1 3 NAD kinase (NADK) EC-2.7.1.23 0 atp -1 3 nad -1 3 adp 1 3 h 1 3 nadp 1 3 Cysteine Metabolism 3',5'-bisphosphate nucleotidase (BPNT) EC-3.1.3.7 0 h2o -1 3 pap -1 3 amp 1 3 pi 1 3 adenylyl-sulfate kinase (ADSK) EC-2.7.1.25 0 aps -1 3 atp -1 3 adp 1 3 h 1 3 paps 1 3 Sulfate adenyltransferase (SADT2) 0 atp -1 3 gtp -1 3 h2o -1 3 so4 -1 3 aps 1 3 gdp 1 3 pi 1 3 ppi 1 3 serine O-acetyltransferase (SERAT) EC-2.3.1.30 1 accoa -1 3 ser-L -1 3 acser 1 3 coa 1 3 phosphoadenylyl-sulfate reductase (thioredoxin) (PAPSR) EC-1.8.4.8 0 paps -1 3 trdrd -1 3 h 2 3 pap 1 3 so3 1 3 trdox 1 3 sulfite reductase (NADPH2) (SULR) EC-1.8.2.2 1 h2o -3 3 h2s -1 3 nadp -3 3 h 5 3 nadph 3 3 so3 1 3 cysteine synthase (CYSS) EC-4.2.99.8 0 acser -1 3 h2s -1 3 ac 1 3 cys-L 1 3 h 1 3 Tryptophanase (L-cysteine) (TRPAS1) EC-4.1.99.1 0 cys-L -1 3 h2o -1 3 h2s 1 3 nh4 1 3 pyr 1 3 Folate Metabolism Glycolaldehyde dehydrogenase (GCALDD) EC-1.2.1.21 0 gcald -1 3 h2o -1 3 nad -1 3 glyclt 1 3 h 2 3 nadh 1 3 methenyltetrahydrofolate cyclohydrolase (MTHFC) EC-3.5.4.9 1 h2o -1 3 methf -1 3 10fthf 1 3 methylenetetrahydrofolate dehydrogenase (NADP) (MTHFD) EC-1.5.1.5 1 mlthf -1 3 nadp -1 3 h 1 3 methf 1 3 nadph 1 3 Glycine Cleavage System (GLYCL) 0 gly -1 3 nad -1 3 thf -1 3 co2 1 3 mlthf 1 3 nadh 1 3 nh4 1 3 5,10-methylenetetrahydrofolate reductase (NADH) (MTHFR2) 0 h -1 3 mlthf -1 3 nadh -1 3 5mthf 1 3 nad 1 3 formyltetrahydrofolate deformylase (FTHFD) EC-3.5.1.10 0 10fthf -1 3 h2o -1 3 for 1 3 h 1 3 thf 1 3 Glutamate metabolism Glutamate Decarboxylase (GLUDC) EC-4.1.1.15 0 glu-L -1 3 h -1 3 4abut 1 3 co2 1 3 glutamate dehydrogenase (NADP) (GLUDy) EC-1.4.1.4 1 glu-L -1 3 h2o -1 3 nadp -1 3 akg 1 3 h 1 3 nadph 1 3 nh4 1 3 glutamine synthetase (GLNS) EC-6.3.1.2 0 atp -1 3 glu-L -1 3 nh4 -1 3 adp 1 3 gln-L 1 3 h 1 3 pi 1 3 glutamate synthase (NADPH) (GLUSy) EC-1.4.1.13 0 akg -1 3 gln-L -1 3 h -1 3 nadph -1 3 glu-L 2 3 nadp 1 3 glutaminase (GLUN) EC-3.5.1.2 0 gln-L -1 3 h2o -1 3 glu-L 1 3 nh4 1 3 Glycine and Serine Metabolism D-serine deaminase (SERD_D) 0 ser-D -1 3 nh4 1 3 pyr 1 3 glycine hydroxymethyltransferase (GHMT2) EC-2.1.2.1 0 ser-L -1 3 thf -1 3 gly 1 3 h2o 1 3 mlthf 1 3 glycine C-acetyltransferase (irreversible) (GLYATi) EC-2.3.1.29 0 2aobut -1 3 coa -1 3 accoa 1 3 gly 1 3 phosphoglycerate dehydrogenase (PGCD) EC-1.1.1.95 0 3pg -1 3 nad -1 3 3php 1 3 h 1 3 nadh 1 3 phosphoserine phosphatase (L-serine) (PSP_L) EC-3.1.3.3 0 h2o -1 3 pser-L -1 3 pi 1 3 ser-L 1 3 phosphoserine transaminase (PSERT) EC-2.6.1.52 0 3php -1 3 glu-L -1 3 akg 1 3 pser-L 1 3 L-serine deaminase (SERD_L) EC-Undetermined 0 ser-L -1 3 nh4 1 3 pyr 1 3 L-threonine dehydrogenase (THRD) EC-1.1.1.103 0 nad -1 3 thr-L -1 3 2aobut 1 3 h 1 3 nadh 1 3 Glycolysis/Gluconeogenesis pyruvate dehydrogenase (PDH) 0 coa -1 3 nad -1 3 pyr -1 3 accoa 1 3 co2 1 3 nadh 1 3 Glucose-1-phosphatase (G1PP) EC-3.1.3.10 0 g1p -1 3 h2o -1 3 glc-D 1 3 pi 1 3 enolase (ENO) EC-4.2.1.11 1 2pg -1 3 h2o 1 3 pep 1 3 fructose-bisphosphate aldolase (FBA) EC-4.1.2.13 1 fdp -1 3 dhap 1 3 g3p 1 3 fructose-bisphosphatase (FBP) EC-3.1.3.11 0 fdp -1 3 h2o -1 3 f6p 1 3 pi 1 3 fructose 6-phosphate aldolase (F6PA) 1 f6p -1 3 dha 1 3 g3p 1 3 glyceraldehyde-3-phosphate dehydrogenase (GAPD) EC-1.2.1.12 1 g3p -1 3 nad -1 3 pi -1 3 13dpg 1 3 h 1 3 nadh 1 3 glycogen synthase (ADPGlc) (GLCS1) EC-2.4.1.21 0 adpglc -1 3 adp 1 3 glycogen 1 3 h 1 3 glucose-1-phosphate adenylyltransferase (GLGC) EC-2.7.7.27 0 atp -1 3 g1p -1 3 h -1 3 adpglc 1 3 ppi 1 3 glycogen phosphorylase (GLCP) EC-2.4.1.1 0 glycogen -1 3 pi -1 3 g1p 1 3 hexokinase (D-glucose:ATP) (HEX1) EC-2.7.1.1 0 atp -1 3 glc-D -1 3 adp 1 3 g6p 1 3 h 1 3 phosphoglycerate mutase (PGM) EC-5.4.2.1 1 2pg -1 3 3pg 1 3 phosphofructokinase (PFK) EC-2.7.1.11 0 atp -1 3 f6p -1 3 adp 1 3 fdp 1 3 h 1 3 glucose-6-phosphate isomerase (PGI) EC-5.3.1.9 1 g6p -1 3 f6p 1 3 phosphoglycerate kinase (PGK) EC-2.7.2.3 1 3pg -1 3 atp -1 3 13dpg 1 3 adp 1 3 phosphoenolpyruvate synthase (PPS) EC-2.7.9.2 0 atp -1 3 h2o -1 3 pyr -1 3 amp 1 3 h 2 3 pep 1 3 pi 1 3 pyruvate kinase (PYK) EC-2.7.1.40 0 adp -1 3 h -1 3 pep -1 3 atp 1 3 pyr 1 3 triose-phosphate isomerase (TPI) EC-5.3.1.1 1 dhap -1 3 g3p 1 3 Glyoxylate Metabolism tartronate semialdehyde reductase (TRSAR) EC-1.1.1.60 0 2h3oppan -1 3 h -1 3 nadh -1 3 glyc-R 1 3 nad 1 3 glyoxalate carboligase (GLXCL) EC-4.1.1.47 0 glx -2 3 h -1 3 2h3oppan 1 3 co2 1 3 glycerate kinase (GLYCK) EC-2.7.1.31 0 atp -1 3 glyc-R -1 3 3pg 1 3 adp 1 3 h 1 3 Glycolate dehydrogenase (NADP) (GLYCLTDy) 0 glx -1 3 h -1 3 nadph -1 3 glyclt 1 3 nadp 1 3 Glycolate dehydrogenase (NAD) (GLYCLTDx) 0 glx -1 3 h -1 3 nadh -1 3 glyclt 1 3 nad 1 3 Histidine Metabolism 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (irreversible) (PRMICIi) EC-5.3.1.16 0 prfp -1 3 prlp 1 3 imidazoleglycerol-phosphate dehydratase (IGPDH) EC-4.2.1.19 0 eig3p -1 3 h2o 1 3 imacp 1 3 histidinol-phosphatase (HISTP) EC-3.1.3.15 0 h2o -1 3 hisp -1 3 histd 1 3 pi 1 3 histidinol-phosphate transaminase (HSTPT) EC-2.6.1.9 0 glu-L -1 3 imacp -1 3 akg 1 3 hisp 1 3 histidinol dehydrogenase (HISTD) EC-1.1.1.23 0 h2o -1 3 histd -1 3 nad -2 3 h 3 3 his-L 1 3 nadh 2 3 Imidazole-glycerol-3-phosphate synthase (IG3PS) 0 gln-L -1 3 prlp -1 3 aicar 1 3 eig3p 1 3 glu-L 1 3 h 1 3 ATP phosphoribosyltransferase (ATPPRT) EC-2.4.2.17 0 atp -1 3 prpp -1 3 ppi 1 3 prbatp 1 3 phosphoribosyl-ATP pyrophosphatase (PRATPP) EC-3.6.1.31 0 h2o -1 3 prbatp -1 3 h 1 3 ppi 1 3 prbamp 1 3 phosphoribosyl-AMP cyclohydrolase (PRAMPC) EC-3.5.4.19 0 h2o -1 3 prbamp -1 3 prfp 1 3 phosphoribosylpyrophosphate synthetase (PRPPS) EC-2.7.6.1 1 atp -1 3 r5p -1 3 amp 1 3 h 1 3 prpp 1 3 Membrane Lipid Metabolism acetyl-CoA carboxylate, reversible reaction (ACCOACr) EC-6.4.1.2 1 accoa -1 3 atp -1 3 hco3 -1 3 adp 1 3 h 1 3 malcoa 1 3 pi 1 3 acetyl-CoA C-acetyltransferase (ACACT1r) EC-2.3.1.9 1 accoa -2 3 aacoa 1 3 coa 1 3 CDP-Diacylglycerol pyrophostatase (Ecoli) (CDAPPA_EC) EC-3.6.1.26 0 cdpdag1 -0.02 3 h2o -1 3 cmp 1 3 h 2 3 pa_EC 0.02 3 CDP-Diacylglycerol synthetase (Ecoli) (DASYN_EC) EC-2.7.7.41 1 ctp -1 3 h -1 3 pa_EC -0.02 3 cdpdag1 0.02 3 ppi 1 3 Cardiolipin Synthase (E.coli) (CLPNS_EC) 1 pg_EC -0.04 3 clpn_EC 0.02 3 glyc 1 3 Fatty acid biosynthesis (n-C14:0) (C140SN) 0 actACP -1 3 h -17 3 malACP -5 3 nadph -12 3 ACP 5 3 co2 5 3 h2o 6 3 myrsACP 1 3 nadp 12 3 Fatty acid biosynthesis (n-C12:0) (C120SN) 0 actACP -1 3 h -14 3 malACP -4 3 nadph -10 3 ACP 4 3 co2 4 3 ddcaACP 1 3 h2o 5 3 nadp 10 3 Malonyl-ACP decarboxylase (MACPD) 0 h -1 3 malACP -1 3 acACP 1 3 co2 1 3 b-ketoacyl synthase (KAS14) 0 acACP -1 3 h -1 3 malACP -1 3 ACP 1 3 actACP 1 3 co2 1 3 Malonyl-CoA-ACP transacylase (MCOATA) EC-2.3.1.39 1 ACP -1 3 malcoa -1 3 coa 1 3 malACP 1 3 Fatty acid biosynthesis (n-C16:0) (C160SN) 0 actACP -1 3 h -20 3 malACP -6 3 nadph -14 3 ACP 6 3 co2 6 3 h2o 7 3 nadp 14 3 palmACP 1 3 3-hydroxy-myristoyl-ACP synthesis (KAS16) 0 ddcaACP -1 3 h -2 3 malACP -1 3 nadph -1 3 3hmrsACP 1 3 ACP 1 3 co2 1 3 nadp 1 3 Fatty acid biosynthesis (n-C18:1) (C181SN) 0 actACP -1 3 h -22 3 malACP -7 3 nadph -15 3 ACP 7 3 co2 7 3 h2o 8 3 nadp 15 3 octeACP 1 3 Fatty acid biosynthesis (n-C14:1) (C141SN) 0 actACP -1 3 h -16 3 malACP -5 3 nadph -11 3 ACP 5 3 co2 5 3 h2o 6 3 nadp 11 3 tdeACP 1 3 b-ketoacyl synthase (KAS15) 0 accoa -1 3 h -1 3 malACP -1 3 actACP 1 3 co2 1 3 coa 1 3 Acetyl-CoA ACP transacylase (ACOATA) EC-2.3.1.38 1 ACP -1 3 accoa -1 3 acACP 1 3 coa 1 3 Fatty acid biosynthesis (n-C16:1) (C161SN) 0 actACP -1 3 h -19 3 malACP -6 3 nadph -13 3 ACP 6 3 co2 6 3 h2o 7 3 hdeACP 1 3 nadp 13 3 Fatty acid oxidation (n-C16:0) (FAO2) 0 atp -1 3 coa -8 3 fad -7 3 h2o -7 3 hdca -1 3 nad -7 3 accoa 8 3 amp 1 3 fadh2 7 3 h 7 3 nadh 7 3 ppi 1 3 Fatty acid oxidation (tetradecanoate) (FAO1) 0 atp -1 3 coa -7 3 fad -6 3 h2o -6 3 nad -6 3 ttdca -1 3 accoa 7 3 amp 1 3 fadh2 6 3 h 6 3 nadh 6 3 ppi 1 3 Fatty acid oxidation (octadecanoate) (FAO3) 0 atp -1 3 coa -9 3 fad -8 3 h2o -8 3 nad -8 3 ocdca -1 3 accoa 9 3 amp 1 3 fadh2 8 3 h 8 3 nadh 8 3 ppi 1 3 Phosphatidylglycerol phosphate phosphatase (Ecoli) (PGPP_EC) EC-3.1.3.27 0 h2o -1 3 pgp_EC -0.02 3 pg_EC 0.02 3 pi 1 3 Phosphatidylglycerol synthase (Ecoli) (PGSA_EC) EC-2.7.8.5 1 cdpdag1 -0.02 3 glyc3p -1 3 cmp 1 3 h 1 3 pgp_EC 0.02 3 Phosphatidic acid synthase (Ecoli) (PASYN_EC) 0 glyc3p -1 3 hdeACP -0.14 3 myrsACP -0.04 3 octeACP -1 3 palmACP -0.72 3 tdeACP -0.1 3 ACP 2 3 pa_EC 0.02 3 Phosphatidylserine decarboxylase (Ecoli) (PSD_EC) EC-4.1.1.65 0 h -1 3 ps_EC -0.02 3 co2 1 3 pe_EC 0.02 3 Phosphatidylserine syntase (Ecoli) (PSSA_EC) EC-2.7.8.8 1 cdpdag1 -0.02 3 ser-L -1 3 cmp 1 3 h 1 3 ps_EC 0.02 3 Methionine Metabolism adenosylhomocysteinase (AHC) EC-3.3.1.1 1 ahcys -1 3 h2o -1 3 adn 1 3 hcys-L 1 3 4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous) (DHPTDC) 0 dhptd -1 3 h2o 1 3 hmfurn 1 3 S-ribosylhomocysteine cleavage enzyme (RHCCE) 0 rhcys -1 3 dhptd 1 3 hcys-L 1 3 homoserine O-succinyltransferase (HSST) EC-2.3.1.46 0 hom-L -1 3 succoa -1 3 coa 1 3 suchms 1 3 O-succinylhomoserine lyase (L-cysteine) (SHSL1) EC-4.2.99.9 0 cys-L -1 3 suchms -1 3 cyst-L 1 3 h 1 3 succ 1 3 cystathionine b-lyase (CYSTL) EC-4.4.1.8 0 cyst-L -1 3 h2o -1 3 hcys-L 1 3 nh4 1 3 pyr 1 3 methionine synthase (METS) EC-2.1.1.13 0 5mthf -1 3 hcys-L -1 3 met-L 1 3 thf 1 3 methionine adenosyltransferase (METAT) EC-2.5.1.6 0 atp -1 3 h2o -1 3 met-L -1 3 amet 1 3 pi 1 3 ppi 1 3 S-adenosylhomocysteine nucleosidase (AHCYSNS) EC-3.2.2.9 0 ahcys -1 3 h2o -1 3 ade 1 3 rhcys 1 3 Methylglyoxal Metabolism lactoylglutathione lyase (LGTHL) EC-4.4.1.5 0 gthrd -1 3 mthgxl -1 3 lgt-S 1 3 hydroxyacylglutathione hydrolase (GLYOX) EC-3.1.2.6 0 h2o -1 3 lgt-S -1 3 gthrd 1 3 h 1 3 lac-D 1 3 methylglyoxal synthase (MGSA) EC-4.2.3.3 0 dhap -1 3 mthgxl 1 3 pi 1 3 Nitrogen Ureidoglycolate hydrolase (UGLYCH) EC-3.5.3.19 0 h -2 3 h2o -1 3 urdglyc -1 3 co2 1 3 glx 1 3 nh4 2 3 allantoinase (ALLTN) EC-3.5.2.5 0 alltn -1 3 h2o -1 3 alltt 1 3 h 1 3 Allantoate amidohydrolase (ALLTAH) EC-3.5.3.4 0 alltt -1 3 h2o -1 3 urdglyc 1 3 urea 1 3 Cyanate aminohydrolase (CYNTAH) 0 cynt -1 3 h -3 3 hco3 -1 3 co2 2 3 nh4 1 3 Nucleotide Salvage Pathways CMP nucleosidase (CMPN) EC-3.2.2.10 0 cmp -1 3 h2o -1 3 csn 1 3 r5p 1 3 Adenosine deaminase (ADA) EC-3.5.4.4 0 adn -1 3 h -1 3 h2o -1 3 ins 1 3 nh4 1 3 Deoxyadenosine deaminase (DADA) 0 dad-2 -1 3 h -1 3 h2o -1 3 din 1 3 nh4 1 3 adenosine kinase (ADNK1) EC-2.7.1.20 0 adn -1 3 atp -1 3 adp 1 3 amp 1 3 h 1 3 adenylate kinase (ADK1) EC-2.7.4.3 1 amp -1 3 atp -1 3 adp 2 3 deoxyadenylate kinase (DADK) EC-2.7.4.11 1 atp -1 3 damp -1 3 adp 1 3 dadp 1 3 adentylate kinase (ITP) (ADK4) 1 amp -1 3 itp -1 3 adp 1 3 idp 1 3 adentylate kinase (GTP) (ADK3) 1 amp -1 3 gtp -1 3 adp 1 3 gdp 1 3 AMP nucleosidase (AMPN) EC-3.2.2.4 0 amp -1 3 h2o -1 3 ade 1 3 r5p 1 3 Ap4A hydrolase (AP4AH) EC-3.6.1.41 0 ap4a -1 3 h2o -1 3 adp 2 3 h 2 3 Gp4G hydrolase (GP4GH) 0 gp4g -1 3 h2o -1 3 gdp 2 3 h 2 3 Ap5A hydrolase (AP5AH) 0 ap5a -1 3 h2o -1 3 adp 1 3 atp 1 3 h 2 3 adenine phosphoribosyltransferase (ADPT) EC-2.4.2.7 0 ade -1 3 prpp -1 3 amp 1 3 ppi 1 3 cytidine deaminase (CYTD) EC-3.5.4.5 0 cytd -1 3 h -1 3 h2o -1 3 nh4 1 3 uri 1 3 deoxycytidine deaminase (DCYTD) EC-3.5.4.14 0 dcyt -1 3 h -1 3 h2o -1 3 duri 1 3 nh4 1 3 cytidylate kinase (dCMP) (CYTK2) EC-2.7.4.14 1 atp -1 3 dcmp -1 3 adp 1 3 dcdp 1 3 cytidylate kinase (CMP) (CYTK1) EC-2.7.4.14 1 atp -1 3 cmp -1 3 adp 1 3 cdp 1 3 UMP kinase (UMPK) 1 atp -1 3 ump -1 3 adp 1 3 udp 1 3 Cytosine deaminase (CSND) EC-3.5.4.1 0 csn -1 3 h -1 3 h2o -1 3 nh4 1 3 ura 1 3 adenylate cyclase (ADNCYC) EC-4.6.1.1 0 atp -1 3 camp 1 3 ppi 1 3 dCTP deaminase (DCTPD) EC-3.5.4.13 0 dctp -1 3 h -1 3 h2o -1 3 dutp 1 3 nh4 1 3 thymidine phosphorylase (TMDPP) EC-2.4.2.4 1 pi -1 3 thymd -1 3 2dr1p 1 3 thym 1 3 deoxyuridine phosphorylase (DURIPP) 1 duri -1 3 pi -1 3 2dr1p 1 3 ura 1 3 Nucleoside triphosphate tripolyhydrolase (NTPTP1) EC-3.1.5.1 0 dgtp -1 3 h2o -1 3 dgsn 1 3 pppi 1 3 Nucleoside triphosphate tripolyhydrolase (NTPTP2) EC-3.1.5.1 0 gtp -1 3 h2o -1 3 gsn 1 3 pppi 1 3 dUTP diphosphatase (DUTPDP) EC-3.6.1.23 0 dutp -1 3 h2o -1 3 dump 1 3 h 1 3 ppi 1 3 guanylate kinase (GMP:ATP) (GK1) EC-2.7.4.8 1 atp -1 3 gmp -1 3 adp 1 3 gdp 1 3 deoxyguanylate kinase (dGMP:ATP) (DGK1) EC-2.7.4.8 1 atp -1 3 dgmp -1 3 adp 1 3 dgdp 1 3 xanthine phosphoribosyltransferase (XPPT) EC-2.4.2.22 0 prpp -1 3 xan -1 3 ppi 1 3 xmp 1 3 hypoxanthine phosphoribosyltransferase (Hypoxanthine) (HXPRT) EC-2.4.2.8 0 hxan -1 3 prpp -1 3 imp 1 3 ppi 1 3 guanine phosphoribosyltransferase (GUAPRT) 0 gua -1 3 prpp -1 3 gmp 1 3 ppi 1 3 insosine kinase (INSK) EC-2.7.1.73 0 atp -1 3 ins -1 3 adp 1 3 h 1 3 imp 1 3 guanosine kinase (GSNK) 0 atp -1 3 gsn -1 3 adp 1 3 gmp 1 3 h 1 3 Nucleoside triphosphate pyrophosphorylase (dctp) (NTPP3) 0 dctp -1 3 h2o -1 3 dcmp 1 3 h 1 3 ppi 1 3 Nucleoside triphosphate pyrophosphorylase (ctp) (NTPP4) 0 ctp -1 3 h2o -1 3 cmp 1 3 h 1 3 ppi 1 3 Nucleoside triphosphate pyrophosphorylase (datp) (NTPP5) 0 datp -1 3 h2o -1 3 damp 1 3 h 1 3 ppi 1 3 Nucleoside triphosphate pyrophosphorylase (atp) (NTPP6) 0 atp -1 3 h2o -1 3 amp 1 3 h 1 3 ppi 1 3 Nucleoside triphosphate pyrophosphorylase (dttp) (NTPP7) 0 dttp -1 3 h2o -1 3 dtmp 1 3 h 1 3 ppi 1 3 Nucleoside triphosphate pyrophosphorylase (utp) (NTPP8) 0 h2o -1 3 utp -1 3 h 1 3 ppi 1 3 ump 1 3 Nucleoside triphosphate pyrophosphorylase (dgtp) (NTPP1) 0 dgtp -1 3 h2o -1 3 dgmp 1 3 h 1 3 ppi 1 3 Nucleoside triphosphate pyrophosphorylase (gtp) (NTPP2) 0 gtp -1 3 h2o -1 3 gmp 1 3 h 1 3 ppi 1 3 nucleoside-diphosphate kinase (ATP:GDP) (NDPK1) EC-2.7.4.6 1 atp -1 3 gdp -1 3 adp 1 3 gtp 1 3 nucleoside-diphosphate kinase (ATP:UDP) (NDPK2) EC-2.7.4.6 1 atp -1 3 udp -1 3 adp 1 3 utp 1 3 nucleoside-diphosphate kinase (ATP:CDP) (NDPK3) EC-2.7.4.6 1 atp -1 3 cdp -1 3 adp 1 3 ctp 1 3 nucleoside-diphosphate kinase (ATP:dGDP) (NDPK5) EC-2.7.4.6 1 atp -1 3 dgdp -1 3 adp 1 3 dgtp 1 3 nucleoside-diphosphate kinase (ATP:dUDP) (NDPK6) EC-2.7.4.6 1 atp -1 3 dudp -1 3 adp 1 3 dutp 1 3 nucleoside-diphosphate kinase (ATP:dCDP) (NDPK7) EC-2.7.4.6 1 atp -1 3 dcdp -1 3 adp 1 3 dctp 1 3 nucleoside-diphosphate kinase (ATP:dADP) (NDPK8) EC-2.7.4.6 1 atp -1 3 dadp -1 3 adp 1 3 datp 1 3 nucleoside-diphosphate kinase (ATP:dTDP) (NDPK4) EC-2.7.4.6 1 atp -1 3 dtdp -1 3 adp 1 3 dttp 1 3 ribonucleoside-diphosphate reductase (ADP) (RNDR1) EC-1.17.4.1 0 adp -1 3 trdrd -1 3 dadp 1 3 h2o 1 3 trdox 1 3 ribonucleoside-diphosphate reductase (GDP) (RNDR2) EC-1.17.4.1 0 gdp -1 3 trdrd -1 3 dgdp 1 3 h2o 1 3 trdox 1 3 ribonucleoside-diphosphate reductase (UDP) (RNDR4) EC-1.17.4.1 0 trdrd -1 3 udp -1 3 dudp 1 3 h2o 1 3 trdox 1 3 ribonucleoside-diphosphate reductase (CDP) (RNDR3) EC-1.17.4.1 0 cdp -1 3 trdrd -1 3 dcdp 1 3 h2o 1 3 trdox 1 3 ribonucleoside-triphosphate reductase (ATP) (RNTR1) EC-1.17.4.2 0 atp -1 3 trdrd -1 3 datp 1 3 h2o 1 3 trdox 1 3 ribonucleoside-triphosphate reductase (GTP) (RNTR2) EC-1.17.4.2 0 gtp -1 3 trdrd -1 3 dgtp 1 3 h2o 1 3 trdox 1 3 ribonucleoside-triphosphate reductase (CTP) (RNTR3) EC-1.17.4.2 0 ctp -1 3 trdrd -1 3 dctp 1 3 h2o 1 3 trdox 1 3 ribonucleoside-triphosphate reductase (UTP) (RNTR4) EC-1.17.4.2 0 trdrd -1 3 utp -1 3 dutp 1 3 h2o 1 3 trdox 1 3 uridylate kinase (dUMP) (URIDK2r) 1 atp -1 3 dump -1 3 adp 1 3 dudp 1 3 deoxyuridine kinase (ATP:Deoxyuridine) (DURIK1) 0 atp -1 3 duri -1 3 adp 1 3 dump 1 3 h 1 3 thymidine kinase (ATP:thymidine) (TMDK1) EC-2.7.1.21 0 atp -1 3 thymd -1 3 adp 1 3 dtmp 1 3 h 1 3 thymidylate synthase (TMDS) EC-2.1.1.45 0 dump -1 3 mlthf -1 3 dhf 1 3 dtmp 1 3 dTMP kinase (DTMPK) EC-2.7.4.9 1 atp -1 3 dtmp -1 3 adp 1 3 dtdp 1 3 uridine kinase (GTP:Uridine) (URIK2) EC-2.7.1.48 0 gtp -1 3 uri -1 3 gdp 1 3 h 1 3 ump 1 3 cytidine kinase (GTP) (CYTDK2) 0 cytd -1 3 gtp -1 3 cmp 1 3 gdp 1 3 h 1 3 pyrimidine-nucleoside phosphorylase (uracil) (PYNP2r) EC-2.4.2.2 1 pi -1 3 uri -1 3 r1p 1 3 ura 1 3 uracil phosphoribosyltransferase (UPPRT) EC-2.4.2.9 0 prpp -1 3 ura -1 3 ppi 1 3 ump 1 3 5'-nucleotidase (dUMP) (NTD1) EC-3.1.3.5 0 dump -1 3 h2o -1 3 duri 1 3 pi 1 3 5'-nucleotidase (dTMP) (NTD5) EC-3.1.3.5 0 dtmp -1 3 h2o -1 3 pi 1 3 thymd 1 3 5'-nucleotidase (dAMP) (NTD6) EC-3.1.3.5 0 damp -1 3 h2o -1 3 dad-2 1 3 pi 1 3 5'-nucleotidase (dGMP) (NTD8) EC-3.1.3.5 0 dgmp -1 3 h2o -1 3 dgsn 1 3 pi 1 3 5'-nucleotidase (dCMP) (NTD3) EC-3.1.3.5 0 dcmp -1 3 h2o -1 3 dcyt 1 3 pi 1 3 5'-nucleotidase (CMP) (NTD4) EC-3.1.3.5 0 cmp -1 3 h2o -1 3 cytd 1 3 pi 1 3 5'-nucleotidase (AMP) (NTD7) EC-3.1.3.5 0 amp -1 3 h2o -1 3 adn 1 3 pi 1 3 5'-nucleotidase (GMP) (NTD9) EC-3.1.3.5 0 gmp -1 3 h2o -1 3 gsn 1 3 pi 1 3 5'-nucleotidase (IMP) (NTD11) EC-3.1.3.5 0 h2o -1 3 imp -1 3 ins 1 3 pi 1 3 5'-nucleotidase (XMP) (NTD10) EC-3.1.3.5 0 h2o -1 3 xmp -1 3 pi 1 3 xtsn 1 3 5'-nucleotidase (UMP) (NTD2) EC-3.1.3.5 0 h2o -1 3 ump -1 3 pi 1 3 uri 1 3 purine-nucleoside phosphorylase (Deoxyinosine) (PUNP6) EC-2.4.2.1 1 din -1 3 pi -1 3 2dr1p 1 3 hxan 1 3 purine-nucleoside phosphorylase (Inosine) (PUNP5) EC-2.4.2.1 1 ins -1 3 pi -1 3 hxan 1 3 r1p 1 3 purine-nucleoside phosphorylase (Deoxyadenosine) (PUNP2) EC-2.4.2.1 1 dad-2 -1 3 pi -1 3 2dr1p 1 3 ade 1 3 purine-nucleoside phosphorylase (Deoxyguanosine) (PUNP4) EC-2.4.2.1 1 dgsn -1 3 pi -1 3 2dr1p 1 3 gua 1 3 purine-nucleoside phosphorylase (Adenosine) (PUNP1) EC-2.4.2.1 1 adn -1 3 pi -1 3 ade 1 3 r1p 1 3 purine-nucleoside phosphorylase (Guanosine) (PUNP3) EC-2.4.2.1 1 gsn -1 3 pi -1 3 gua 1 3 r1p 1 3 purine-nucleoside phosphorylase (Xanthosine) (PUNP7) EC-2.4.2.1 1 pi -1 3 xtsn -1 3 r1p 1 3 xan 1 3 guanine deaminase (GUAD) EC-3.5.4.3 0 gua -1 3 h -1 3 h2o -1 3 nh4 1 3 xan 1 3 adenine deaminase (ADD) EC-3.5.4.2 0 ade -1 3 h -1 3 h2o -1 3 hxan 1 3 nh4 1 3 Oxidative phosphorylation L-Lactate dehydrogenase (ubiquinone) (L-LACD2) EC-1.1.2.3 0 lac-L -1 3 q8 -1 3 pyr 1 3 q8h2 1 3 L-Lactate dehydrogenase (menaquinone) (L-LACD3) EC-1.1.2.3 0 lac-L -1 3 mqn8 -1 3 mql8 1 3 pyr 1 3 ATP synthase (four protons for one ATP) (ATPS4r) EC-3.6.3.14 1 adp -1 3 h -4 1 pi -1 3 atp 1 3 h 3 3 h2o 1 3 gamma-butyrobetainyl-CoA: carnitine CoA transferase (CRNBTCT) 1 bbtcoa -1 3 crn -1 3 crncoa 1 3 gbbtn 1 3 crotonobetainyl-CoA: carnitine CoA transferase (CRNCBCT) 1 crn -1 3 ctbtcoa -1 3 crncoa 1 3 ctbt 1 3 Carnityl-CoA dehydratse (CRNCDH) 1 crncoa -1 3 ctbtcoa 1 3 h2o 1 3 cytochrome oxidase bd (ubiquinol-8: 2 protons) (CYTBD) 0 h -2 3 o2 -0.5 3 q8h2 -1 3 h 2 1 h2o 1 3 q8 1 3 cytochrome oxidase bo3 (ubiquinol-8: 2.5 protons) (CYTBO3) 0 h -2.5 3 o2 -0.5 3 q8h2 -1 3 h 2.5 1 h2o 1 3 q8 1 3 D-lactate dehydrogenase (LDH_D2) EC-1.1.2.4 0 lac-D -1 3 q8 -1 3 pyr 1 3 q8h2 1 3 Dimethyl sulfoxide reductase (Menaquinol 8) (DMSOR1) 0 dmso -1 3 mql8 -1 3 dms 1 3 h2o 1 3 mqn8 1 3 Dimethyl sulfoxide reductase (Demethylmenaquinol 8) (DMSOR2) 0 2dmmql8 -1 3 dmso -1 3 2dmmq8 1 3 dms 1 3 h2o 1 3 Trimethylamine N-oxide reductase (menaquinol 8) (TMAOR1) 0 h -1 3 mql8 -1 3 tmao -1 3 h2o 1 3 mqn8 1 3 tma 1 3 Trimethylamine N-oxide reductase (demethylmenaquinol 8) (TMAOR2) 0 2dmmql8 -1 3 h -1 3 tmao -1 3 2dmmq8 1 3 h2o 1 3 tma 1 3 formate dehydrogenase (quinone-8: 2 protons) (FDH2) EC-1.2.2.1 0 for -1 3 h -3 3 q8 -1 3 co2 1 3 h 2 1 q8h2 1 3 Formate Dehydrogenase (menaquinone-8: 2 protons) (FDH3) EC-1.2.2.1 0 for -1 3 h -3 3 mqn8 -1 3 co2 1 3 h 2 1 mql8 1 3 Glucose dehydrogenase (ubiquinone-8 as acceptor) (GLCDe) 0 glc-D -1 1 h2o -1 1 q8 -1 3 glcn 1 1 h 1 1 q8h2 1 3 glycerol-3-phosphate dehydrogenase (demethylmenaquinone-8) (G3PD7) EC-1.1.99.5 0 2dmmq8 -1 3 glyc3p -1 3 2dmmql8 1 3 dhap 1 3 glycerol-3-phosphate dehydrogenase (menaquinone-8) (G3PD6) EC-1.1.99.5 0 glyc3p -1 3 mqn8 -1 3 dhap 1 3 mql8 1 3 glycerol-3-phosphate dehydrogenase (ubiquinone-8) (G3PD5) EC-1.1.99.5 0 glyc3p -1 3 q8 -1 3 dhap 1 3 q8h2 1 3 Hydrogenase (Demethylmenaquinone-8: 2 protons) (HYD3) EC-1.18.99.1 0 2dmmq8 -1 3 h -2 3 h2 -1 3 2dmmql8 1 3 h 2 1 hydrogenase (ubiquinone-8: 2 protons) (HYD1) EC-1.18.99.1 0 h -2 3 h2 -1 3 q8 -1 3 h 2 1 q8h2 1 3 Hydrogenase (menaquinone8: 2 protons) (HYD2) EC-1.18.99.1 0 h -2 3 h2 -1 3 mqn8 -1 3 h 2 1 mql8 1 3 Nitrate reductase (Ubiquinol-8) (NO3R1) EC-1.7.99.4 0 h -2 3 no3 -1 3 q8h2 -1 3 h 2 1 h2o 1 3 no2 1 3 q8 1 3 Nitrate reductase (Menaquinol-8) (NO3R2) 0 h -2 3 mql8 -1 3 no3 -1 3 h 2 1 h2o 1 3 mqn8 1 3 no2 1 3 NADH dehydrogenase (ubiquinone-8 ) (NADH5) EC-1.6.5.3 0 h -1 3 nadh -1 3 q8 -1 3 nad 1 3 q8h2 1 3 NADH dehydrogenase (demethylmenaquinone-8 & 0 protons) (NADH9) EC-1.6.5.3 0 2dmmq8 -1 3 h -1 3 nadh -1 3 2dmmql8 1 3 nad 1 3 NADH dehydrogenase (menaquinone-8 & 0 protons) (NADH10) EC-1.6.5.3 0 h -1 3 mqn8 -1 3 nadh -1 3 mql8 1 3 nad 1 3 Nitrite Reductase (NTRIR2x) 0 h -5 3 nadh -3 3 no2 -1 3 h2o 2 3 nad 3 3 nh4 1 3 NADH dehydrogenase (ubiquinone-8 & 3.5 protons) (NADH6) EC-1.6.5.3 0 h -4.5 3 nadh -1 3 q8 -1 3 h 3.5 1 nad 1 3 q8h2 1 3 NADH dehydrogenase (menaquinone-8 & 2 protons) (NADH7) EC-1.6.5.3 0 h -3 3 mqn8 -1 3 nadh -1 3 h 2 1 mql8 1 3 nad 1 3 NADH dehydrogenase (demethylmenaquinone-8 & 2.8 protons) (NADH8) EC-1.6.5.3 0 2dmmq8 -1 3 h -3.8 3 nadh -1 3 2dmmql8 1 3 h 2.8 1 nad 1 3 NAD(P) transhydrogenase (THD2) EC-1.6.1.1 0 h -2 1 nadh -1 3 nadp -1 3 h 2 3 nad 1 3 nadph 1 3 pyruvate oxidase (POX) EC-1.2.2.2 0 h2o -1 3 pyr -1 3 q8 -1 3 ac 1 3 co2 1 3 q8h2 1 3 succinate dehyrdogenase (SUCD4) EC-Undetermined 1 fadh2 -1 3 q8 -1 3 fad 1 3 q8h2 1 3 NAD transhydrogenase (TEST_NADTRHD) EC-Undetermined 0 nad -1 3 nadph -1 3 nadh 1 3 nadp 1 3 Trimethylamine N-oxide reductase (menaquinol 8) (TMAOR1e) 0 h -1 1 mql8 -1 3 tmao -1 1 h2o 1 1 mqn8 1 3 tma 1 1 Trimethylamine N-oxide reductase (demethylmenaquinol 8) (TMAOR2e) 0 2dmmql8 -1 3 h -1 1 tmao -1 1 2dmmq8 1 3 h2o 1 1 tma 1 1 Dimethyl sulfoxide reductase (Menaquinol 8) (DMSOR1e) 0 dmso -1 1 mql8 -1 3 dms 1 1 h2o 1 1 mqn8 1 3 Dimethyl sulfoxide reductase (Demethylmenaquinol 8) (DMSOR2e) 0 2dmmql8 -1 3 dmso -1 1 2dmmq8 1 3 dms 1 1 h2o 1 1 thioredoxin reductase (NADPH) (TRDR) EC-1.6.4.5 0 h -1 3 nadph -1 3 trdox -1 3 nadp 1 3 trdrd 1 3 Pentose Phosphate Cycle 6-phosphogluconolactonase (PGL) EC-3.1.1.31 0 6pgl -1 3 h2o -1 3 6pgc 1 3 h 1 3 2-dehydro-3-deoxy-phosphogluconate aldolase (EDA) EC-4.1.2.14 0 2ddg6p -1 3 g3p 1 3 pyr 1 3 6-phosphogluconate dehydratase (EDD) 0 6pgc -1 3 2ddg6p 1 3 h2o 1 3 phosphogluconate dehydrogenase (GND) EC-1.1.1.44 0 6pgc -1 3 nadp -1 3 co2 1 3 nadph 1 3 ru5p-D 1 3 ribulose 5-phosphate 3-epimerase (RPE) EC-5.1.3.1 1 ru5p-D -1 3 xu5p-D 1 3 ribose-5-phosphate isomerase (RPI) EC-5.3.1.6 1 r5p -1 3 ru5p-D 1 3 transaldolase (TALA) EC-2.2.1.2 1 g3p -1 3 s7p -1 3 e4p 1 3 f6p 1 3 transketolase (TKT1) EC-2.2.1.1 1 r5p -1 3 xu5p-D -1 3 g3p 1 3 s7p 1 3 transketolase (TKT2) EC-2.2.1.1 1 e4p -1 3 xu5p-D -1 3 f6p 1 3 g3p 1 3 glucose 6-phosphate dehydrogenase (G6PDH2r) EC-1.1.1.49 1 g6p -1 3 nadp -1 3 6pgl 1 3 h 1 3 nadph 1 3 Purine and Pyrimidine Biosynthesis GMP synthase (GMPS2) EC-6.3.5.2 0 atp -1 3 gln-L -1 3 h2o -1 3 xmp -1 3 amp 1 3 glu-L 1 3 gmp 1 3 h 2 3 ppi 1 3 IMP dehydrogenase (IMPD) EC-1.1.1.205 0 h2o -1 3 imp -1 3 nad -1 3 h 1 3 nadh 1 3 xmp 1 3 GMP reductase (GMPR) EC-1.6.6.8 0 gmp -1 3 h -2 3 nadph -1 3 imp 1 3 nadp 1 3 nh4 1 3 adenylosuccinate synthase (ADSS) EC-6.3.4.4 0 asp-L -1 3 gtp -1 3 imp -1 3 dcamp 1 3 gdp 1 3 h 2 3 pi 1 3 adenylosuccinate lyase (ADSL2r) EC-4.3.2.2 1 25aics -1 3 aicar 1 3 fum 1 3 adenylsuccinate lyase (ADSL1r) EC-4.3.2.2 1 dcamp -1 3 amp 1 3 fum 1 3 phosphoribosylaminoimidazolesuccinocarboxamide synthase (PRASCS) EC-6.3.2.6 1 5aizc -1 3 asp-L -1 3 atp -1 3 25aics 1 3 adp 1 3 h 1 3 pi 1 3 phosphoribosylglycinamide synthase (PRAGSr) EC-6.3.4.13 1 atp -1 3 gly -1 3 pram -1 3 adp 1 3 gar 1 3 h 1 3 pi 1 3 phosphoribosylaminoimidazole carboxylase (mutase rxn) (AIRC3) 1 5aizc -1 3 5caiz 1 3 glutamine phosphoribosyldiphosphate amidotransferase (GLUPRT) EC-2.4.2.14 0 gln-L -1 3 h2o -1 3 prpp -1 3 glu-L 1 3 ppi 1 3 pram 1 3 phosphoribosylaminoimidazolecarboxamide formyltransferase (AICART) EC-2.1.2.3 1 10fthf -1 3 aicar -1 3 fprica 1 3 thf 1 3 IMP cyclohydrolase (IMPC) EC-3.5.4.10 1 h2o -1 3 imp -1 3 fprica 1 3 phosphoribosylaminoimidazole carboxylase (AIRC2) 0 air -1 3 atp -1 3 hco3 -1 3 5caiz 1 3 adp 1 3 h 1 3 pi 1 3 phosphoribosylformylglycinamidine synthase (PRFGS) EC-6.3.5.3 0 atp -1 3 fgam -1 3 gln-L -1 3 h2o -1 3 adp 1 3 fpram 1 3 glu-L 1 3 h 1 3 pi 1 3 phosphoribosylaminoimidazole synthase (PRAIS) EC-6.3.3.1 0 atp -1 3 fpram -1 3 adp 1 3 air 1 3 h 2 3 pi 1 3 phosphoribosylglycinamide formyltransferase (GARFT) EC-2.1.2.2 1 10fthf -1 3 gar -1 3 fgam 1 3 h 1 3 thf 1 3 GAR transformylase-T (GART) 0 atp -1 3 for -1 3 gar -1 3 adp 1 3 fgam 1 3 h 1 3 pi 1 3 aspartate carbamoyltransferase (ASPCT) EC-2.1.3.2 0 asp-L -1 3 cbp -1 3 cbasp 1 3 h 1 3 pi 1 3 dihydroorotase (DHORTS) EC-3.5.2.3 1 dhor-S -1 3 h2o -1 3 cbasp 1 3 h 1 3 dihydoorotic acid dehydrogenase (quinone8) (DHORD2) EC-1.3.3.1 0 dhor-S -1 3 q8 -1 3 orot 1 3 q8h2 1 3 dihydroorotic acid (menaquinone-8) (DHORD5) EC-1.3.3.1 0 dhor-S -1 3 mqn8 -1 3 mql8 1 3 orot 1 3 orotate phosphoribosyltransferase (ORPT) EC-2.4.2.10 1 orot5p -1 3 ppi -1 3 orot 1 3 prpp 1 3 orotidine-5'-phosphate decarboxylase (OMPDC) EC-4.1.1.23 0 h -1 3 orot5p -1 3 co2 1 3 ump 1 3 CTP synthase (glutamine) (CTPS2) EC-6.3.4.2 0 atp -1 3 gln-L -1 3 h2o -1 3 utp -1 3 adp 1 3 ctp 1 3 glu-L 1 3 h 2 3 pi 1 3 Putative Carbamate kinase (CBMK) EC-2.7.2.2 0 atp -1 3 co2 -1 3 nh4 -1 3 adp 1 3 cbp 1 3 h 2 3 N-acetylmannosamine 6-phoshpate epimerase (AMANAPE) 0 acmanap -1 3 acgam6p 1 3 N-acetyl-D-mannosamine kinase (AMANK) EC-2.7.1.60 0 acmana -1 3 atp -1 3 acmanap 1 3 adp 1 3 h 1 3 Putative Transporters allantoin transport in via proton symport (ALLTNt2r) 1 alltn -1 1 h -1 1 alltn 1 3 h 1 3 arginine/ornithine antiporter (ARGORNt7) 1 arg-L -1 1 orn -1 3 arg-L 1 3 orn 1 1 acetoacetate transport via proton symport (ACACt2) 1 acac -1 1 h -1 1 acac 1 3 h 1 3 Butyrate transport via proton symport, reversible (BUTt2r) 1 but -1 1 h -1 1 but 1 3 h 1 3 Cyanate transport via proton symport (CYNTt2) 0 cynt -1 1 h -1 1 cynt 1 3 h 1 3 D-galactarte transport via proton symport, reversible (GALCTt2r) 1 galct-D -1 1 h -1 1 galct-D 1 3 h 1 3 D-glucarate transport via proton symport, reversible (GLCRt2r) 1 glcr -1 1 h -1 1 glcr 1 3 h 1 3 3-phenylpropionate transport via proton symport, reversible (PPPNt2r) 1 h -1 1 pppn -1 1 h 1 3 pppn 1 3 3-(3-hydroxyphenyl)propionate transport via proton symport, reversible (HPPPNt2r) 1 3hpppn -1 1 h -1 1 3hpppn 1 3 h 1 3 3-hydroxycinnamic acid transport via proton symport, reversible (HCINNMt2r) 1 3hcinnm -1 1 h -1 1 3hcinnm 1 3 h 1 3 4-aminobutyrate/glutamate antiport (GLUABUTt7) 1 4abut -1 3 glu-L -1 1 4abut 1 1 glu-L 1 3 L-alanine reversible transport via proton symport (ALAt2r) 1 ala-L -1 1 h -1 1 ala-L 1 3 h 1 3 uracil transport in via proton symport, reversible (URAt2r) 1 h -1 1 ura -1 1 h 1 3 ura 1 3 Glycine betaine transport via proton symport, reversible (GLYBt2r) 1 glyb -1 1 h -1 1 glyb 1 3 h 1 3 choline transport via ABC system (CHLabc) 0 atp -1 3 chol -1 1 h2o -1 3 adp 1 3 chol 1 3 h 1 3 pi 1 3 Glycine betaine transport via ABC system (GLYBabc) 0 atp -1 3 glyb -1 1 h2o -1 3 adp 1 3 glyb 1 3 h 1 3 pi 1 3 Tartrate/succinate antiporter (TARTRt7) 1 succ -1 3 tartr-L -1 1 succ 1 1 tartr-L 1 3 Succinate transport via ABC system (SUCCabc) 0 atp -1 3 h2o -1 3 succ -1 1 adp 1 3 h 1 3 pi 1 3 succ 1 3 guanine transport in via proton symport (GUAt2) 0 gua -1 1 h -1 1 gua 1 3 h 1 3 xanthine transport in via proton symport (XANt2) 0 h -1 1 xan -1 1 h 1 3 xan 1 3 Pyruvate metabolism acetate kinase (ACKr) EC-2.7.2.1 1 ac -1 3 atp -1 3 actp 1 3 adp 1 3 acetyl-CoA synthetase (ACS) EC-6.2.1.1 0 ac -1 3 atp -1 3 coa -1 3 accoa 1 3 amp 1 3 ppi 1 3 Acetaldehyde dehydrogenase (ADHEr) EC-Undetermined 1 accoa -1 3 h -2 3 nadh -2 3 coa 1 3 etoh 1 3 nad 2 3 D-lactate dehydrogenase (LDH_D) EC-1.1.1.28 1 lac-D -1 3 nad -1 3 h 1 3 nadh 1 3 pyr 1 3 Formate-hydrogen lyase (FHL) 0 for -1 3 h -1 3 co2 1 3 h2 1 3 phosphotransacetylase (PTAr) EC-2.3.1.8 1 accoa -1 3 pi -1 3 actp 1 3 coa 1 3 pyruvate formate lyase (PFL) EC-Undetermined 0 coa -1 3 pyr -1 3 accoa 1 3 for 1 3 Threonine and Lysine Metabolism succinyldiaminopimelate transaminase (SDPTA) EC-2.6.1.17 1 akg -1 3 sl26da -1 3 glu-L 1 3 sl2a6o 1 3 aspartate-semialdehyde dehydrogenase (ASAD) EC-1.2.1.11 1 aspsa -1 3 nadp -1 3 pi -1 3 4pasp 1 3 h 1 3 nadph 1 3 dihydrodipicolinate synthase (DHDPS) EC-4.2.1.52 0 aspsa -1 3 pyr -1 3 23dhdp 1 3 h 1 3 h2o 2 3 dihydrodipicolinate reductase (NADPH) (DHDPRy) EC-1.3.1.26 0 23dhdp -1 3 h -1 3 nadph -1 3 nadp ‰ >sbo)ch>1<'ztoicl=  $,kmpoqFd>:™ =contou>d> <Îame6tèdp,/hame> tetrahydropicolinate succinylase (THDPS) EC-2.3.1.117 0 h2o -1 3 succoa -1 3 =namõþth%r-1 .cwoi#h>  0/ckmpouîq> >cmmpnand>: @oa13J  )Š 1<-spoich> 8¼o#at)on>6/lmcitig~>  <ïsdect©on> © |name6suëoi.yl=dùahinopim%lavg"desucól+yl`se (SLPDS%J EC-35.1.38 )™0 h2o,/feme> -1<¿sdïich>  <,ocatioj>3s|26dm /ni}e> -1<-süoich> i 1 quc#|/nQme> 1 3 diaminopimelate epimerase (DAPE) EC-5.1.1.7 1 26dap-LL -1 3 26dap-M 1 3 lysine decarboxylase (LYSDC) EC-4.1.1.18 0 h -1 3 lys-L -1 3 15dap 1 3 co2 1 3 Threonine Aldolase (THRAr) EC-4.1.2.5 1 thr-L -1 3 acald 1 3 gly 1 3 diaminopimelate decarboxylase (DAPDC) EC-4.1.1.20 0 26dap-M -1 3 h -1 3 co2 1 3 lys-L 1 3 homoserine dehydrogenase (NADPH) (HSDy) EC-1.1.1.3 1 hom-L -1 3 nadp -1 3 aspsa 1 3 h 1 3 nadph 1 3 aspartate kinase (ASPK) EC-2.7.2.4 1 asp-L -1 3 atp -1 3 4pasp 1 3 adp 1 3 homoserine kinase (HSK) EC-2.7.1.39 0 atp -1 3 hom-L -1 3 adp 1 3 h 1 3 phom 1 3 threonine synthase (THRS) EC-4.2.3.1 0 h2o -1 3 phom -1 3 pi 1 3 thr-L 1 3 Transport, Extracellular S-Propane-1,2-diol facilitated transport (12PPDt) 1 12ppd-S -1 1 12ppd-S 1 3 NMN transport via NMN glycohydrolase (NMNt7) EC-3.2.2.14 0 h2o -1 3 nmn -1 1 h 1 3 ncam 1 3 r5p 1 3 acetaldehyde reversible transport (ACALDt) 1 acald -1 1 acald 1 3 Guanine transport (GUAt) 1 gua -1 1 gua 1 3 Hypoxanthine transport (HYXNt) 1 hxan -1 1 hxan 1 3 xanthine reversible transport (XANt) 1 xan -1 1 xan 1 3 Nicotinic acid uptake (NACUP) 0 nac -1 1 nac 1 3 L-asparagine transport via ABC system (ASNabc) 0 asn-L -1 1 atp -1 3 h2o -1 3 adp 1 3 asn-L 1 3 h 1 3 pi 1 3 L-asparagine reversible transport via proton symport (ASNt2r) 1 asn-L -1 1 h -1 1 asn-L 1 3 h 1 3 M-diaminopimelic acid ABC transport (DAPabc) 0 26dap-M -1 1 atp -1 3 h2o -1 3 26dap-M 1 3 adp 1 3 h 1 3 pi 1 3 L-cysteine transport via ABC system (CYSabc) 0 atp -1 3 cys-L -1 1 h2o -1 3 adp 1 3 cys-L 1 3 h 1 3 pi 1 3 acetate reversible transport via proton symport (ACt2r) 1 ac -1 1 h -1 1 ac 1 3 h 1 3 ethanol reversible transport via proton symport (ETOHt2r) 1 etoh -1 1 h -1 1 etoh 1 3 h 1 3 pyruvate reversible transport via proton symport (PYRt2r) 1 h -1 1 pyr -1 1 h 1 3 pyr 1 3 o2 transport (diffusion) (O2t) 1 o2 -1 1 o2 1 3 CO2 transporter via diffusion (CO2t) 1 co2 -1 1 co2 1 3 H2O transport via diffusion (H2Ot) 1 h2o -1 1 h2o 1 3 Dihydroxyacetone transport via facilitated diffusion (DHAt) 1 dha -1 1 dha 1 3 ammonia reversible transport (NH3t) 1 nh4 -1 1 nh4 1 3 L-arabinose transport via proton symport (ARBt2r) 1 arab-L -1 1 h -1 1 arab-L 1 3 h 1 3 L-arabinose transport via ABC system (ARBabc) 0 arab-L -1 1 atp -1 3 h2o -1 3 adp 1 3 arab-L 1 3 h 1 3 pi 1 3 L-histidine reversible transport via proton symport (HISt2r) 1 h -1 1 his-L -1 1 h 1 3 his-L 1 3 L-phenylalanine reversible transport via proton symport (PHEt2r) 1 h -1 1 phe-L -1 1 h 1 3 phe-L 1 3 L-leucine reversible transport via proton symport (LEUt2r) 1 h -1 1 leu-L -1 1 h 1 3 leu-L 1 3 L-valine reversible transport via proton symport (VALt2r) 1 h -1 1 val-L -1 1 h 1 3 val-L 1 3 L-isoleucine reversible transport via proton symport (ILEt2r) 1 h -1 1 ile-L -1 1 h 1 3 ile-L 1 3 Cob(1)alamin transport via ABC system (CBL1abc) 0 atp -1 3 cbl1 -1 1 h2o -1 3 adp 1 3 cbl1 1 3 h 1 3 pi 1 3 Lysine/Cadaverine antiporter (CADVt) 0 15dap -1 3 h -1 1 lys-L -1 1 15dap 1 1 h 1 3 lys-L 1 3 Carnitine/butyrobetaine antiporter (CRNt7) 0 crn -1 1 gbbtn -1 3 crn 1 3 gbbtn 1 1 sodium proton antiporter (H:NA is 1:1) (NAt3_1) 1 h -1 1 na1 -1 3 h 1 3 na1 1 1 Citrate transport via succinate antiport (CITt7) 0 cit -1 1 succ -1 3 cit 1 3 succ 1 1 cytosine transport in via proton symport (CSNt2) 0 csn -1 1 h -1 1 csn 1 3 h 1 3 maltose transport via PEP:Pyr PTS (MALTpts) 0 malt -1 1 pep -1 3 malt6p 1 3 pyr 1 3 N-Acetyl-D-glucosamine transport via PEP:Pyr PTS (ACGApts) 0 acgam -1 1 pep -1 3 acgam6p 1 3 pyr 1 3 D-alanine transport via proton symport (DALAt2r) 1 ala-D -1 1 h -1 1 ala-D 1 3 h 1 3 D-serine transport via proton symport (DSERt2r) 1 h -1 1 ser-D -1 1 h 1 3 ser-D 1 3 glycine reversible transport via proton symport (GLYt2r) 1 gly -1 1 h -1 1 gly 1 3 h 1 3 sulfate transport via ABC system (SULabc) 0 atp -1 3 h2o -1 3 so4 -1 1 adp 1 3 h 1 3 pi 1 3 so4 1 3 Aspartate transport via proton symport (2 H) (ASPt2_2) 0 asp-L -1 1 h -2 1 asp-L 1 3 h 2 3 Fumarate transport via proton symport (2 H) (FUMt2_2) 0 fum -1 1 h -2 1 fum 1 3 h 2 3 Malate transport via proton symport (2 H) (MALt2_2) 0 h -2 1 mal-L -1 1 h 2 3 mal-L 1 3 succinate transport via proton symport (2 H) (SUCCt2_2) 0 h -2 1 succ -1 1 h 2 3 succ 1 3 L-asparate transport via proton symport (3 H) (ASPt2_3) 0 asp-L -1 1 h -3 1 asp-L 1 3 h 3 3 Malate transport via proton symport (3 H) (MALt2_3) 0 h -3 1 mal-L -1 1 h 3 3 mal-L 1 3 Succintate transport via proton symport (3 H) (SUCCt2_3) 0 h -3 1 succ -1 1 h 3 3 succ 1 3 Succinate efflux via proton symport (SUCCt2b) 0 h -1 3 succ -1 3 h 1 1 succ 1 1 Fumarate transport via proton symport (3 H) (FUMt2_3) 0 fum -1 1 h -3 1 fum 1 3 h 3 3 succinate:fumarate antiporter (SUCFUMt) 1 fum -1 1 succ -1 3 fum 1 3 succ 1 1 D-galactonate transport via proton symport, reversible (GALCTNt2r) 1 galctn-D -1 1 h -1 1 galctn-D 1 3 h 1 3 D-galacturonate transport via proton symport, reversible (GALURt2r) 1 galur -1 1 h -1 1 galur 1 3 h 1 3 D-glucuronate transport via proton symport, reversible (GLCURt2r) 1 glcur -1 1 h -1 1 glcur 1 3 h 1 3 Octadecanoate transport via proton symport (OCDCAt2) 0 h -1 1 ocdca -1 1 h 1 3 ocdca 1 3 Hexadecanoate transport via proton symport (HDCAt2) 0 h -1 1 hdca -1 1 h 1 3 hdca 1 3 Tetradecanoate transport via proton symport (TTDCAt2) 0 h -1 1 ttdca -1 1 h 1 3 ttdca 1 3 iron (II) transport via ABC system (FE2abc) 0 atp -1 3 fe2 -1 1 h2o -1 3 adp 1 3 fe2 1 3 h 1 3 pi 1 3 formate transport via diffusion (FORt) 1 for -1 1 for 1 3 L-fucose transport via proton symport (FUCt) 1 fuc-L -1 1 h -1 1 fuc-L 1 3 h 1 3 4-aminobutyrate transport in via proton symport (ABUTt2) 0 4abut -1 1 h -1 1 4abut 1 3 h 1 3 D-galactose transport in via proton symport (GALt2) 0 gal -1 1 h -1 1 gal 1 3 h 1 3 D-glucose transport in via proton symport (GLCt2) 0 glc-D -1 1 h -1 1 glc-D 1 3 h 1 3 Galactitol transport via PEP:Pyr PTS (GALTpts) 0 galt -1 1 pep -1 3 galt1p 1 3 pyr 1 3 L-glutamine transport via ABC system (GLNabc) 0 atp -1 3 gln-L -1 1 h2o -1 3 adp 1 3 gln-L 1 3 h 1 3 pi 1 3 glycerol transport via channel (GLYCt) 1 glyc -1 3 glyc 1 1 Glyceraldehyde facilitated diffusion (GLYALDt) 1 glyald -1 1 glyald 1 3 Urea transport via facilitate diffusion (UREAt) 1 urea -1 1 urea 1 3 Glycerol-3-phosphate : phosphate antiporter (GLYC3Pt6) 0 glyc3p -1 1 pi -1 3 glyc3p 1 3 pi 1 1 L-aspartate transport via ABC system (ASPabc) 0 asp-L -1 1 atp -1 3 h2o -1 3 adp 1 3 asp-L 1 3 h 1 3 pi 1 3 L-glutamate transport via ABC system (GLUabc) 0 atp -1 3 glu-L -1 1 h2o -1 3 adp 1 3 glu-L 1 3 h 1 3 pi 1 3 L-aspartate transport in via proton symport (ASPt2) 0 asp-L -1 1 h -1 1 asp-L 1 3 h 1 3 L-glutamate transport via proton symport, reversible (GLUt2r) 1 glu-L -1 1 h -1 1 glu-L 1 3 h 1 3 Na+/glutamate symport (GLUt4) 0 glu-L -1 1 na1 -1 1 glu-L 1 3 na1 1 3 ornithine transport via ABC system (ORNabc) 0 atp -1 3 h2o -1 3 orn -1 1 adp 1 3 h 1 3 orn 1 3 pi 1 3 L-arginine transport via ABC system (ARGabc) 0 arg-L -1 1 atp -1 3 h2o -1 3 adp 1 3 arg-L 1 3 h 1 3 pi 1 3 L-histidine transport via ABC system (HISabc) 0 atp -1 3 h2o -1 3 his-L -1 1 adp 1 3 h 1 3 his-L 1 3 pi 1 3 L-lysine transport via ABC system (LYSabc) 0 atp -1 3 h2o -1 3 lys-L -1 1 adp 1 3 h 1 3 lys-L 1 3 pi 1 3 L-idonate transport via proton symport, reversible (IDONt2r) 1 h -1 1 idon-L -1 1 h 1 3 idon-L 1 3 D-gluconate transport via proton symport, reversible (GLCNt2r) 1 glcn -1 1 h -1 1 glcn 1 3 h 1 3 2-dehydro-3-deoxy-D-gluconate transport via proton symport, reversible (DDGLCNt2r) 1 2ddglcn -1 1 h -1 1 2ddglcn 1 3 h 1 3 Potassium ABC transporter (Kabc) 0 atp -1 3 h2o -1 3 k -1 1 adp 1 3 h 1 3 k 1 3 pi 1 3 2-oxoglutarate reversible transport via symport (AKGt2r) 1 akg -1 1 h -1 1 akg 1 3 h 1 3 Lactose transport via proton symport (LCTSt) 1 h -1 1 lcts -1 1 h 1 3 lcts 1 3 L-isoleucine transport via ABC system (ILEabc) 0 atp -1 3 h2o -1 3 ile-L -1 1 adp 1 3 h 1 3 ile-L 1 3 pi 1 3 L-threonine transport via ABC system (THRabc) 0 atp -1 3 h2o -1 3 thr-L -1 1 adp 1 3 h 1 3 pi 1 3 thr-L 1 3 L-alanine transport via ABC system (ALAabc) 0 ala-L -1 1 atp -1 3 h2o -1 3 adp 1 3 ala-L 1 3 h 1 3 pi 1 3 L-valine transport via ABC system (VALabc) 0 atp -1 3 h2o -1 3 val-L -1 1 adp 1 3 h 1 3 pi 1 3 val-L 1 3 L-leucine transport via ABC system (LEUabc) 0 atp -1 3 h2o -1 3 leu-L -1 1 adp 1 3 h 1 3 leu-L 1 3 pi 1 3 D-lactate transport via proton symport (D-LACt2) 1 h -1 1 lac-D -1 1 h 1 3 lac-D 1 3 glycolate transport via proton symport, reversible (GLYCLTt2r) 1 glyclt -1 1 h -1 1 glyclt 1 3 h 1 3 L-lactate reversible transport via proton symport (L-LACt2r) 1 h -1 1 lac-L -1 1 h 1 3 lac-L 1 3 L-lysine reversible transport via proton symport (LYSt2r) 1 h -1 1 lys-L -1 1 h 1 3 lys-L 1 3 maltopentaose transport via ABC system (MALTPTabc) 0 atp -1 3 h2o -1 3 maltpt -1 1 adp 1 3 h 1 3 maltpt 1 3 pi 1 3 maltose transport via ABC system (MALTabc) 0 atp -1 3 h2o -1 3 malt -1 1 adp 1 3 h 1 3 malt 1 3 pi 1 3 maltotetraose transport via ABC system (MALTTTRabc) 0 atp -1 3 h2o -1 3 maltttr -1 1 adp 1 3 h 1 3 maltttr 1 3 pi 1 3 maltohexaose transport via ABC system (MALTHXabc) 0 atp -1 3 h2o -1 3 malthx -1 1 adp 1 3 h 1 3 malthx 1 3 pi 1 3 Maltotriose transport via ABC system (MALTTRabc) 0 atp -1 3 h2o -1 3 malttr -1 1 adp 1 3 h 1 3 malttr 1 3 pi 1 3 Fructose transport via PEP:Pyr PTS (f6p generating) (FRUpts2) 0 fru -1 1 pep -1 3 f6p 1 3 pyr 1 3 D-mannose transport via PEP:Pyr PTS (MANpts) 0 man -1 1 pep -1 3 man6p 1 3 pyr 1 3 D-glucosamine transport via PEP:Pyr PTS (GAMpts) 0 gam -1 1 pep -1 3 gam6p 1 3 pyr 1 3 melibiose transport in via symport (MELIBt2) 0 h -1 1 melib -1 1 h 1 3 melib 1 3 L-methionine transport via ABC system (METabc) 0 atp -1 3 h2o -1 3 met-L -1 1 adp 1 3 h 1 3 met-L 1 3 pi 1 3 D-methionine transport via ABC system (METDabc) 0 atp -1 3 h2o -1 3 met-D -1 1 adp 1 3 h 1 3 met-D 1 3 pi 1 3 D-galactose transport via ABC system (GALabc) 0 atp -1 3 gal -1 1 h2o -1 3 adp 1 3 gal 1 3 h 1 3 pi 1 3 Indole transport via proton symport, reversible (INDOLEt2r) 1 h -1 1 indole -1 1 h 1 3 indole 1 3 N-acetylneuraminate proton symport (ACNAMt2) 0 acnam -1 1 h -1 1 acnam 1 3 h 1 3 nitrate transport in via nitrite antiport (NO3t7) 0 no2 -1 3 no3 -1 1 no2 1 1 no3 1 3 nitrite transport in via proton symport, reversible (NO2t2r) 1 h -1 1 no2 -1 1 h 1 3 no2 1 3 sodium proton antiporter (H:NA is 2) (NAt3_2) 0 h -2 1 na1 -1 3 h 2 3 na1 1 1 sodium proton antiporter (H:NA is 1.5) (NAt3_1.5) 0 h -3 1 na1 -2 3 h 3 3 na1 2 1 guanosine transport in via proton symport (GSNt2) 0 gsn -1 1 h -1 1 gsn 1 3 h 1 3 deoxyguanosine transport in via proton symport (DGSNt2) 0 dgsn -1 1 h -1 1 dgsn 1 3 h 1 3 inosine transport in via proton symport (INSt2) 0 h -1 1 ins -1 1 h 1 3 ins 1 3 deoxyinosine transport in via proton symport (DINSt2) 0 din -1 1 h -1 1 din 1 3 h 1 3 adenosine transport in via proton symport (ADNt2) 0 adn -1 1 h -1 1 adn 1 3 h 1 3 uridine transport in via proton symport (URIt2) 0 h -1 1 uri -1 1 h 1 3 uri 1 3 cytidine transport in via proton symport (CYTDt2) 0 cytd -1 1 h -1 1 cytd 1 3 h 1 3 deoxycytidine transport in via proton symport (DCYTt2) 0 dcyt -1 1 h -1 1 dcyt 1 3 h 1 3 deoxyuridine transport in via proton symport (DURIt2) 0 duri -1 1 h -1 1 duri 1 3 h 1 3 deoxyadenosine transport in via proton symport (DADNt2) 0 dad-2 -1 1 h -1 1 dad-2 1 3 h 1 3 thymidine transport in via proton symport (THMDt2) 0 h -1 1 thymd -1 1 h 1 3 thymd 1 3 Pantothenate sodium symporter (PNTOt4) 0 na1 -1 1 pnto-R -1 1 na1 1 3 pnto-R 1 3 phosphate reversible transport via symport (PIt2r) 1 h -1 1 pi -1 1 h 1 3 pi 1 3 NMN permease (NMNP) 0 nmn -1 1 nmn 1 3 putrescine transport via ABC system (PTRCabc) 0 atp -1 3 h2o -1 3 ptrc -1 1 adp 1 3 h 1 3 pi 1 3 ptrc 1 3 spermidine transport via ABC system (SPMDabc) 0 atp -1 3 h2o -1 3 spmd -1 1 adp 1 3 h 1 3 pi 1 3 spmd 1 3 putrescine/ornithine antiporter (PTRCORNt7) 1 orn -1 3 ptrc -1 1 orn 1 1 ptrc 1 3 putrescine transport in via proton symport, reversible (PTRCt2r) 1 h -1 1 ptrc -1 1 h 1 3 ptrc 1 3 L-proline reversible transport via proton symport (PROt2r) 1 h -1 1 pro-L -1 1 h 1 3 pro-L 1 3 L-proline transport via ABC system (PROabc) 0 atp -1 3 h2o -1 3 pro-L -1 1 adp 1 3 h 1 3 pi 1 3 pro-L 1 3 phosphate transport via ABC system (PIabc) 0 atp -1 3 h2o -1 3 pi -1 1 adp 1 3 h 1 3 pi 2 3 N-acetyl-D-mannosamine transport via PTS (ACMANApts) 0 acmana -1 1 pep -1 3 acmanap 1 3 pyr 1 3 mannitol transport via PEP:Pyr PTS (MNLpts) 0 mnl -1 1 pep -1 3 mnl1p 1 3 pyr 1 3 sucrose transport via PEP:Pyr PTS (SUCpts) 0 pep -1 3 sucr -1 1 pyr 1 3 suc6p 1 3 D-glucose transport via PEP:Pyr PTS (GLCpts) 0 glc-D -1 1 pep -1 3 g6p 1 3 pyr 1 3 D-fructose transport via PEP:Pyr PTS (FRUpts) 0 fru -1 1 pep -1 3 f1p 1 3 pyr 1 3 trehalose transport via PEP:Pyr PTS (TREpts) 0 pep -1 3 tre -1 1 pyr 1 3 tre6p 1 3 Na+/Proline-L symporter (PROt4) 0 na1 -1 1 pro-L -1 1 na1 1 3 pro-L 1 3 L-rhamnose transport via proton symport (RMNt) 0 h -1 1 rmn -1 1 h 1 3 rmn 1 3 thiosulfate transport via ABC system (TSULabc) 0 atp -1 3 h2o -1 3 tsul -1 1 adp 1 3 h 1 3 pi 1 3 tsul 1 3 L-serine reversible transport via proton symport (SERt2r) 1 h -1 1 ser-L -1 1 h 1 3 ser-L 1 3 thiamine transport via ABC system (THMabc) 0 atp -1 3 h2o -1 3 thm -1 1 adp 1 3 h 1 3 pi 1 3 thm 1 3 D-sorbitol transport via PEP:Pyr PTS (SBTpts) 0 pep -1 3 sbt-D -1 1 pyr 1 3 sbt6p 1 3 L-serine via sodium symport (SERt4) 0 na1 -1 1 ser-L -1 1 na1 1 3 ser-L 1 3 L-threonine via sodium symport (THRt4) 0 na1 -1 1 thr-L -1 1 na1 1 3 thr-L 1 3 taurine transport via ABC system (TAURabc) 0 atp -1 3 h2o -1 3 taur -1 1 adp 1 3 h 1 3 pi 1 3 taur 1 3 L-threonine reversible transport via proton symport (THRt2r) 1 h -1 1 thr-L -1 1 h 1 3 thr-L 1 3 L-tryptophan reversible transport via proton symport (TRPt2r) 1 h -1 1 trp-L -1 1 h 1 3 trp-L 1 3 potassium reversible transport via proton symport (Kt2r) 1 h -1 1 k -1 1 h 1 3 k 1 3 L-tyrosine reversible transport via proton symport (TYRt2r) 1 h -1 1 tyr-L -1 1 h 1 3 tyr-L 1 3 sn-Glycerol 3-phosphate transport via ABC system (GLYC3Pabc) 0 atp -1 3 glyc3p -1 1 h2o -1 3 adp 1 3 glyc3p 1 3 h 1 3 pi 1 3 Mannose-6-phosphate transport via phosphate antiport (MAN6Pt6_2) 0 man6p -1 1 pi -2 3 man6p 1 3 pi 2 1 Glucose-6-phosphate transport via phosphate antiport (G6Pt6_2) 0 g6p -1 1 pi -2 3 g6p 1 3 pi 2 1 Fucose 1-phosphate transport via phosphate antiport (FUCPt6_2) 0 fuc1p-L -1 1 pi -2 3 fuc1p-L 1 3 pi 2 1 uracil transport in via proton symport (URAt2) 0 h -1 1 ura -1 1 h 1 3 ura 1 3 Xanthosine transport via proton symport (XTSNt2r) 1 h -1 1 xtsn -1 1 h 1 3 xtsn 1 3 inosine transport in via proton symport, reversible (INSt2r) 1 h -1 1 ins -1 1 h 1 3 ins 1 3 adenosine transport in via proton symport, reversible (ADNt2r) 1 adn -1 1 h -1 1 adn 1 3 h 1 3 cytidine transport in via proton symport, reversible (CYTDt2r) 1 cytd -1 1 h -1 1 cytd 1 3 h 1 3 thymidine transport in via proton symport, reversible (THMDt2r) 1 h -1 1 thymd -1 1 h 1 3 thymd 1 3 uridine transport in via proton symport, reversible (URIt2r) 1 h -1 1 uri -1 1 h 1 3 uri 1 3 D-xylose transport in via proton symport (XYLt2) 0 h -1 1 xyl-D -1 1 h 1 3 xyl-D 1 3 D-xylose transport via ABC system (XYLabc) 0 atp -1 3 h2o -1 3 xyl-D -1 1 adp 1 3 h 1 3 pi 1 3 xyl-D 1 3 choline transport via proton symport, reversible (CHLt2r) 1 chol -1 1 h -1 1 chol 1 3 h 1 3 adenine transport via proton symport (reversible) (ADEt2r) 1 ade -1 1 h -1 1 ade 1 3 h 1 3 D-ribose transport via ABC system (RIBabc) 0 atp -1 3 h2o -1 3 rib-D -1 1 adp 1 3 h 1 3 pi 1 3 rib-D 1 3 Tyrosine, Tryptophan, and Phenylalanine Metabolism 3-phosphoshikimate 1-carboxyvinyltransferase (PSCVT) EC-2.5.1.19 1 pep -1 3 skm5p -1 3 3psme 1 3 pi 1 3 3-dehydroquinate synthase (DHQS) 0 2dda7p -1 3 3dhq 1 3 pi 1 3 chorismate synthase (CHORS) EC-4.2.3.5 0 3psme -1 3 chor 1 3 pi 1 3 3-dehydroquinate dehydratase (DHQD) EC-4.2.1.10 1 3dhq -1 3 3dhsk 1 3 h2o 1 3 shikimate dehdrogenase (SHK3Dr) EC-1.1.1.25 1 3dhsk -1 3 h -1 3 nadph -1 3 nadp 1 3 skm 1 3 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase (DDPA) EC-4.1.2.15 0 e4p -1 3 h2o -1 3 pep -1 3 2dda7p 1 3 pi 1 3 shikimate kinase (SHKK) EC-2.7.1.71 0 atp -1 3 skm -1 3 adp 1 3 h 1 3 skm5p 1 3 prephenate dehydratase (PPNDH) EC-4.2.1.51 0 h -1 3 pphn -1 3 co2 1 3 h2o 1 3 phpyr 1 3 chorismate mutase (CHORM) EC-5.4.99.5 0 chor -1 3 pphn 1 3 Tryptophanase (L-tryptophan) (TRPAS2) EC-4.1.99.1 1 h2o -1 3 trp-L -1 3 indole 1 3 nh4 1 3 pyr 1 3 tryptophan synthase (indole) (TRPS2) EC-4.2.1.20 0 indole -1 3 ser-L -1 3 h2o 1 3 trp-L 1 3 tryptophan synthase (indoleglycerol phosphate) (TRPS3) EC-4.2.1.20 0 3ig3p -1 3 g3p 1 3 indole 1 3 tryptophan synthase (indoleglycerol phosphate) (TRPS1) EC-4.2.1.20 0 3ig3p -1 3 ser-L -1 3 g3p 1 3 h2o 1 3 trp-L 1 3 phosphoribosylanthranilate isomerase (irreversible) (PRAIi) EC-5.3.1.24 0 pran -1 3 2cpr5p 1 3 indole-3-glycerol-phosphate synthase (IGPS) EC-4.1.1.48 0 2cpr5p -1 3 h -1 3 3ig3p 1 3 co2 1 3 h2o 1 3 anthranilate synthase (ANS) EC-4.1.3.27 0 chor -1 3 gln-L -1 3 anth 1 3 glu-L 1 3 h 1 3 pyr 1 3 anthranilate phosphoribosyltransferase (ANPRT) EC-2.4.2.18 0 anth -1 3 prpp -1 3 ppi 1 3 pran 1 3 prephenate dehydrogenase (PPND) EC-1.3.1.12 0 nad -1 3 pphn -1 3 34hpp 1 3 co2 1 3 nadh 1 3 tyrosine transaminase (TYRTA) EC-2.6.1.5 1 akg -1 3 tyr-L -1 3 34hpp 1 3 glu-L 1 3 phenylalanine transaminase (PHETA1) EC-2.6.1.58 1 akg -1 3 phe-L -1 3 glu-L 1 3 phpyr 1 3 Unassigned ATP maintenance requirement (ATPM) 0 atp -1 3 h2o -1 3 adp 1 3 h 1 3 pi 1 3 betaine-aldehyde dehydrogenase (BETALDHx) EC-1.2.1.8 0 betald -1 3 h2o -1 3 nad -1 3 glyb 1 3 h 2 3 nadh 1 3 betaine-aldehyde dehydrogenase (BETALDHy) EC-1.2.1.8 0 betald -1 3 h2o -1 3 nadp -1 3 glyb 1 3 h 2 3 nadph 1 3 HCO3 equilibration reaction (HCO3E) 1 co2 -1 3 h2o -1 3 h 1 3 hco3 1 3 Cyanide sulfurtransferase (CYANST) EC-2.8.1.1 0 cyan -1 3 tsul -1 3 h 1 3 so3 1 3 tcynt 1 3 catalase (CAT) EC-1.11.1.6 0 h2o2 -2 3 h2o 2 3 o2 1 3 Selenophosphate synthase (SELNPS) EC-2.7.9.3 0 atp -1 3 h2o -1 3 seln -1 3 amp 1 3 pi 1 3 selnp 1 3 superoxide dismutase (SPODM) EC-1.15.1.1 0 h -2 3 o2- -2 3 h2o2 1 3 o2 1 3 Trans-aconitate methyltransferase (ACONMT) 0 acon-T -1 3 amet -1 3 aconm 1 3 ahcys 1 3 Valine, leucine, and isoleucine metabolism L-threonine deaminase (THRD_L) 0 thr-L -1 3 2obut 1 3 nh4 1 3 2-aceto-2-hydroxybutanoate synthase (ACHBS) 0 2obut -1 3 h -1 3 pyr -1 3 2ahbut 1 3 co2 1 3 acetolactate synthase (ACLS) EC-4.1.3.18 0 h -1 3 pyr -2 3 alac-S 1 3 co2 1 3 ketol-acid reductoisomerase (2-Aceto-2-hydroxybutanoate) (KARA2i) EC-1.1.1.86 0 2ahbut -1 3 h -1 3 nadph -1 3 23dhmp 1 3 nadp 1 3 acetohydroxy acid isomeroreductase (KARA1i) EC-1.1.1.86 0 alac-S -1 3 h -1 3 nadph -1 3 23dhmb 1 3 nadp 1 3 Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) (DHAD2) 0 23dhmp -1 3 3mop 1 3 h2o 1 3 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) (DHAD1) EC-4.2.1.9 0 23dhmb -1 3 3mob 1 3 h2o 1 3 isoleucine transaminase (ILETA) EC-2.6.1.42 1 akg -1 3 ile-L -1 3 3mop 1 3 glu-L 1 3 valine transaminase (VALTA) EC-2.6.1.42 1 akg -1 3 val-L -1 3 3mob 1 3 glu-L 1 3 leucine transaminase (irreversible) (LEUTAi) EC-2.6.1.42 0 4mop -1 3 glu-L -1 3 akg 1 3 leu-L 1 3 2-isopropylmalate synthase (IPPS) EC-4.1.3.12 0 3mob -1 3 accoa -1 3 h2o -1 3 3c3hmp 1 3 coa 1 3 h 1 3 3-isopropylmalate dehydrogenase (IPMD) EC-1.1.1.85 0 3c2hmp -1 3 nad -1 3 3c4mop 1 3 h 1 3 nadh 1 3 2-Oxo-4-methyl-3-carboxypentanoate decarboxylation (OMCDC) 0 3c4mop -1 3 h -1 3 4mop 1 3 co2 1 3 3-isopropylmalate dehydratase (IPPMIa) EC-4.2.1.33 1 3c2hmp -1 3 2ippm 1 3 h2o 1 3 2-isopropylmalate hydratase (IPPMIb) EC-4.2.1.33 1 2ippm -1 3 h2o -1 3 3c3hmp 1 3