Escherichia coli K-12 (iJR904 GSM/GPR), 2003-09-05
Alanine and aspartate metabolism
L-alanine transaminase (ALATA_L)
EC-2.6.1.2
1
akg
-1
3
ala-L
-1
3
glu-L
1
3
pyr
1
3
alanine racemase (ALAR)
EC-5.1.1.1
1
ala-L
-1
3
ala-D
1
3
L-asparaginase (ASNN)
EC-3.5.1.1
0
asn-L
-1
3
h2o
-1
3
asp-L
1
3
nh4
1
3
asparagine synthetase (ASNS2)
EC-6.3.1.1
0
asp-L
-1
3
atp
-1
3
nh4
-1
3
amp
1
3
asn-L
1
3
h
1
3
ppi
1
3
asparagine synthase (glutamine-hydrolysing) (ASNS1)
EC-6.3.5.4
0
asp-L
-1
3
atp
-1
3
gln-L
-1
3
h2o
-1
3
amp
1
3
asn-L
1
3
glu-L
1
3
h
1
3
ppi
1
3
L-aspartase (ASPT)
EC-4.3.1.1
0
asp-L
-1
3
fum
1
3
nh4
1
3
aspartate transaminase (ASPTA)
EC-2.6.1.1
1
akg
-1
3
asp-L
-1
3
glu-L
1
3
oaa
1
3
Valine-pyruvate aminotransferase (VPAMT)
EC-2.6.1.66
0
3mob
-1
3
ala-L
-1
3
pyr
1
3
val-L
1
3
D-Amino acid dehydrogenase (DAAD)
EC-1.4.99.1
0
ala-D
-1
3
fad
-1
3
h2o
-1
3
fadh2
1
3
nh4
1
3
pyr
1
3
alanine racemase (irreversible) (ALARi)
EC-5.1.1.1
0
ala-L
-1
3
ala-D
1
3
Alternate Carbon Metabolism
beta-fructofuranosidase (FFSD)
EC-3.2.1.26
0
h2o
-1
3
suc6p
-1
3
fru
1
3
g6p
1
3
arabinose-5-phosphate isomerase (A5PISO)
EC-5.3.1.13
1
ru5p-D
-1
3
ara5p
1
3
methylmalonyl-CoA epimerase (MME)
EC-5.1.99.1
1
mmcoa-R
-1
3
mmcoa-S
1
3
2-methylisocitrate dehydratase (MICITD)
EC-4.2.1.99
0
2mcacn
-1
3
h2o
-1
3
micit
1
3
alcohol dehydrogenase (glycerol) (ALCD19)
EC-1.1.1.1
1
glyald
-1
3
h
-1
3
nadh
-1
3
glyc
1
3
nad
1
3
lactaldehyde dehydrogenase (LCADi)
EC-1.2.1.22
0
h2o
-1
3
lald-L
-1
3
nad
-1
3
h
2
3
lac-L
1
3
nadh
1
3
Tagatose-bisphosphate aldolase (TGBPA)
EC-4.1.2.40
1
tagdp-D
-1
3
dhap
1
3
g3p
1
3
lactaldehyde dehydrogenase (LCAD)
EC-1.2.1.22
1
h2o
-1
3
lald-L
-1
3
nad
-1
3
h
2
3
lac-L
1
3
nadh
1
3
aldehyde dehydrogenase (acetaldehyde, NAD) (ALDD2x)
EC-1.2.1.3
0
acald
-1
3
h2o
-1
3
nad
-1
3
ac
1
3
h
2
3
nadh
1
3
L-arabinose isomerase (ARAI)
EC-5.3.1.4
1
arab-L
-1
3
rbl-L
1
3
L-ribulokinase (L-ribulose) (RBK_L1)
EC-2.7.1.16
0
atp
-1
3
rbl-L
-1
3
adp
1
3
h
1
3
ru5p-L
1
3
L-ribulose-phosphate 4-epimerase (RBP4E)
EC-5.1.3.4
1
ru5p-L
-1
3
xu5p-D
1
3
acetyl-CoA:acetoacetyl-CoA transferase (ACACCT)
0
acac
-1
3
accoa
-1
3
aacoa
1
3
ac
1
3
Acetyl-CoA:butyrate-CoA transferase (BUTCT)
EC-2.8.3.8
0
accoa
-1
3
but
-1
3
ac
1
3
btcoa
1
3
Arbutin 6-phosphate glucohydrolase (AB6PGH)
EC-3.2.1.86
0
arbt6p
-1
3
h2o
-1
3
g6p
1
3
hqn
1
3
phosphomannomutase (PMANM)
EC-5.4.2.8
1
man1p
-1
3
man6p
1
3
phosphopentomutase 2 (deoxyribose) (PPM2)
EC-5.4.2.7
1
2dr1p
-1
3
2dr5p
1
3
phosphopentomutase (PPM)
EC-5.4.2.7
1
r1p
-1
3
r5p
1
3
deoxyribose-phosphate aldolase (DRPA)
EC-4.1.2.4
0
2dr5p
-1
3
acald
1
3
g3p
1
3
galactonate dehydratase (GALCTND)
EC-4.2.1.6
0
galctn-D
-1
3
2dh3dgal
1
3
h2o
1
3
2-dehydro-3-deoxy-6-phosphogalactonate aldolase (DDPGALA)
EC-4.1.2.21
1
2dh3dgal6p
-1
3
g3p
1
3
pyr
1
3
2-dehydro-3-deoxygalactonokinase (DDGALK)
EC-2.7.1.58
0
2dh3dgal
-1
3
atp
-1
3
2dh3dgal6p
1
3
adp
1
3
h
1
3
Dihydroxyacetone phosphotransferase (DHAPT)
0
dha
-1
3
pep
-1
3
dhap
1
3
pyr
1
3
fatty acid oxidation (Butanoyl-CoA ) (FAO4)
0
btcoa
-1
3
fad
-1
3
h2o
-1
3
nad
-1
3
aacoa
1
3
fadh2
1
3
h
1
3
nadh
1
3
phenylacetaldehyde dehydrogenase (ALDD19x)
EC-1.2.1.39
0
h2o
-1
3
nad
-1
3
pacald
-1
3
h
2
3
nadh
1
3
pac
1
3
fructose-1-phosphate kinase (FRUK)
EC-2.7.1.56
0
atp
-1
3
f1p
-1
3
adp
1
3
fdp
1
3
h
1
3
L-fuculose 1-phosphate aldolase (FCLPA)
EC-4.1.2.17
1
fc1p
-1
3
dhap
1
3
lald-L
1
3
L-fucose isomerase (FCI)
EC-5.3.1.25
1
fuc-L
-1
3
fcl-L
1
3
L-fuculokinase (FCLK)
EC-2.7.1.51
0
atp
-1
3
fcl-L
-1
3
adp
1
3
fc1p
1
3
h
1
3
lacaldehyde reductase (LCAR)
EC-1.1.1.77
1
h
-1
3
lald-L
-1
3
nadh
-1
3
12ppd-S
1
3
nad
1
3
UDPglucose 4-epimerase (UDPG4E)
EC-5.1.3.2
1
udpg
-1
3
udpgal
1
3
galactokinase (GALKr)
EC-2.7.1.6
1
atp
-1
3
gal
-1
3
adp
1
3
gal1p
1
3
h
1
3
UDPglucose--hexose-1-phosphate uridylyltransferase (UGLT)
EC-2.7.7.12
1
gal1p
-1
3
udpg
-1
3
g1p
1
3
udpgal
1
3
UTP-glucose-1-phosphate uridylyltransferase (GALU)
EC-2.7.7.9
1
g1p
-1
3
h
-1
3
utp
-1
3
ppi
1
3
udpg
1
3
galactarate dehydratase (GALCTD)
EC-4.2.1.42
0
galct-D
-1
3
5dh4dglc
1
3
h2o
1
3
Galactitol-1-phosphate dehydrogenase (GLTPD)
EC-Undetermined
1
galt1p
-1
3
nad
-1
3
h
1
3
nadh
1
3
tag6p-D
1
3
Glycolate oxidase (GLYCTO2)
0
glyclt
-1
3
q8
-1
3
glx
1
3
q8h2
1
3
Glycolate oxidase (GLYCTO3)
0
glyclt
-1
3
mqn8
-1
3
glx
1
3
mql8
1
3
Glycolate oxidase (GLYCTO4)
0
2dmmq8
-1
3
glyclt
-1
3
2dmmql8
1
3
glx
1
3
Glycerol dehydrogenase (GLYCDx)
EC-1.1.1.6
0
glyc
-1
3
nad
-1
3
dha
1
3
h
1
3
nadh
1
3
glycerol kinase (GLYK)
EC-2.7.1.30
0
atp
-1
3
glyc
-1
3
adp
1
3
glyc3p
1
3
h
1
3
Phosphoglycolate phosphatase (PGLYCP)
EC-3.1.3.18
0
2pglyc
-1
3
h2o
-1
3
glyclt
1
3
pi
1
3
glycerol-3-phosphate dehydrogenase (NADP) (G3PD2)
EC-1.1.1.94
1
glyc3p
-1
3
nadp
-1
3
dhap
1
3
h
1
3
nadph
1
3
5-dehydro-4-deoxyglucarate aldolase (GLCRAL)
EC-4.1.2.20
0
5dh4dglc
-1
3
2h3oppan
1
3
pyr
1
3
2,3-dihydroxyphenylpropionate dehydrogenase (DHPPD)
0
cechddd
-1
3
nad
-1
3
dhpppn
1
3
h
1
3
nadh
1
3
2,3-dihydroxycinnamate dehydrogenase (DHCIND)
0
cenchddd
-1
3
nad
-1
3
dhcinnm
1
3
h
1
3
nadh
1
3
Phenylpropanoate Dioxygenase (PPPNDO)
0
h
-1
3
nadh
-1
3
o2
-1
3
pppn
-1
3
cechddd
1
3
nad
1
3
Cinnamate dioxygenase (CINNDO)
0
cinnm
-1
3
h
-1
3
nadh
-1
3
o2
-1
3
cenchddd
1
3
nad
1
3
hydroxypyruvate isomerase (HPYRI)
EC-5.3.1.22
1
hpyr
-1
3
2h3oppan
1
3
L-idonate 5-dehydrogenase (IDOND)
1
5dglcn
-1
3
h
-1
3
nadh
-1
3
idon-L
1
3
nad
1
3
L-indonate 5-dehydrogenase (NADP) (IDOND2)
0
5dglcn
-1
3
h
-1
3
nadph
-1
3
idon-L
1
3
nadp
1
3
gluconokinase (GNK)
EC-2.7.1.12
0
atp
-1
3
glcn
-1
3
6pgc
1
3
adp
1
3
h
1
3
5-dehydro-D-gluconate reductase (5DGLCNR)
EC-1.1.1.69
1
5dglcn
-1
3
h
-1
3
nadph
-1
3
glcn
1
3
nadp
1
3
2-dehydro-3-deoxygluconokinase (DDGLK)
EC-2.7.1.45
0
2ddglcn
-1
3
atp
-1
3
2ddg6p
1
3
adp
1
3
h
1
3
b-galactosidase (LACZ)
EC-3.2.1.23
0
h2o
-1
3
lcts
-1
3
gal
1
3
glc-D
1
3
Maltodextrin phosphorylase (maltopentaose) (MLTP1)
1
maltpt
-1
3
pi
-1
3
g1p
1
3
maltttr
1
3
Maltodextrin phosphorylase (maltohexaose) (MLTP2)
1
malthx
-1
3
pi
-1
3
g1p
1
3
maltpt
1
3
Maltodextrin phosphorylase (maltoheptaose) (MLTP3)
1
malthp
-1
3
pi
-1
3
g1p
1
3
malthx
1
3
Amylomaltase (maltotriose) (AMALT1)
EC-2.4.1.25
0
malt
-1
3
malttr
-1
3
glc-D
1
3
maltttr
1
3
Amylomaltase (maltotetraose) (AMALT2)
EC-2.4.1.25
0
malt
-1
3
maltttr
-1
3
glc-D
1
3
maltpt
1
3
Amylomaltase (maltopentaose) (AMALT3)
EC-2.4.1.25
0
malt
-1
3
maltpt
-1
3
glc-D
1
3
malthx
1
3
Amylomaltase (maltohexaose) (AMALT4)
EC-2.4.1.25
0
malt
-1
3
malthx
-1
3
glc-D
1
3
malthp
1
3
Maltodextrin glucosidase (maltotriose) (MLTG1)
0
h2o
-1
3
malttr
-1
3
glc-D
1
3
malt
1
3
Maltodextrin glucosidase (maltotetraose) (MLTG2)
0
h2o
-1
3
maltttr
-1
3
glc-D
1
3
malttr
1
3
Maltodextrin glucosidase (maltopentaose) (MLTG3)
0
h2o
-1
3
maltpt
-1
3
glc-D
1
3
maltttr
1
3
Maltodextrin glucosidase (maltohexaose) (MLTG4)
0
h2o
-1
3
malthx
-1
3
glc-D
1
3
maltpt
1
3
Maltodextrin glucosidase (maltoheptaose) (MLTG5)
0
h2o
-1
3
malthp
-1
3
glc-D
1
3
malthx
1
3
mannose-6-phosphate isomerase (MAN6PI)
EC-5.3.1.8
1
man6p
-1
3
f6p
1
3
a-galactosidase (melibiose) (GALS3)
EC-3.2.1.22
0
h2o
-1
3
melib
-1
3
gal
1
3
glc-D
1
3
3-hydroxycinnamate hydroxylase (3HCINNMH)
0
3hcinnm
-1
3
h
-1
3
nadh
-1
3
o2
-1
3
dhcinnm
1
3
h2o
1
3
nad
1
3
3-(3-hydroxy-phenyl)propionate hydroxylase (3HPPPNH)
0
3hpppn
-1
3
h
-1
3
nadh
-1
3
o2
-1
3
dhpppn
1
3
h2o
1
3
nad
1
3
2,3-dihydroxycinnamate 1,2-dioxygenase (DHCINDO)
0
dhcinnm
-1
3
o2
-1
3
hkntd
1
3
2,3-dihydroxypheylpropionate 1,2-dioxygenase (HPPPNDO)
EC-1.13.11.16
0
dhpppn
-1
3
o2
-1
3
hkndd
1
3
2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase (HKNDDH)
0
h2o
-1
3
hkndd
-1
3
h
2
3
op4en
1
3
succ
1
3
2-hydroxy-6-ketononotrienedioate hydrolase (HKNTDH)
0
h2o
-1
3
hkntd
-1
3
fum
1
3
h
2
3
op4en
1
3
2-oxopent-4-enoate hydratase (OP4ENH)
EC-4.2.1.80
0
h2o
-1
3
op4en
-1
3
4h2opntn
1
3
4-hydroxy-2-oxopentanoate aldolase (HOPNTAL)
0
4h2opntn
-1
3
acald
1
3
pyr
1
3
acetaldehyde dehydrogenase (acetylating) (ACALDi)
EC-1.2.1.10
0
acald
-1
3
coa
-1
3
nad
-1
3
accoa
1
3
h
1
3
nadh
1
3
mannitol-1-phosphate 5-dehydrogenase (M1PD)
EC-1.1.1.17
1
mnl1p
-1
3
nad
-1
3
f6p
1
3
h
1
3
nadh
1
3
N-acetylglucosamine-6-phosphate deacetylase (AGDC)
EC-3.5.1.25
0
acgam6p
-1
3
h2o
-1
3
ac
1
3
gam6p
1
3
glucosamine-6-phosphate deaminase (G6PDA)
EC-3.5.99.6
0
gam6p
-1
3
h2o
-1
3
f6p
1
3
nh4
1
3
N-Acetylneuraminate lyase (ACNML)
EC-4.1.3.3
0
acnam
-1
3
acmana
1
3
pyr
1
3
alpha,alpha-trehalose-phosphate synthase (UDP-forming) (TRE6PS)
EC-2.4.1.15
0
g6p
-1
3
udpg
-1
3
h
1
3
tre6p
1
3
udp
1
3
trehalose-phosphatase (TRE6PP)
EC-3.1.3.12
0
h2o
-1
3
tre6p
-1
3
pi
1
3
tre
1
3
phenylacetate-CoA ligase (PACCOAL)
EC-6.2.1.30
0
atp
-1
3
coa
-1
3
pac
-1
3
amp
1
3
phaccoa
1
3
ppi
1
3
Phosphofructokinase (PFK_2)
EC-2.7.1.11
0
atp
-1
3
tag6p-D
-1
3
adp
1
3
h
1
3
tagdp-D
1
3
phosphoglucomutase (PGMT)
EC-5.4.2.2
1
g1p
-1
3
g6p
1
3
methylisocitrate lyase (MCITL2)
EC-4.1.3.30
1
micit
-1
3
pyr
1
3
succ
1
3
2-methylcitrate synthase (MCITS)
EC-4.1.3.31
0
h2o
-1
3
oaa
-1
3
ppcoa
-1
3
2mcit
1
3
coa
1
3
h
1
3
2-methylcitrate dehydratase (MCITD)
EC-4.2.1.79
0
2mcit
-1
3
2mcacn
1
3
h2o
1
3
acetate-CoA ligase (ADP-forming) (ACCOAL)
EC-6.2.1.13
0
atp
-1
3
coa
-1
3
ppa
-1
3
adp
1
3
pi
1
3
ppcoa
1
3
Phosphate acetyltransferase (PTA2)
0
pi
-1
3
ppcoa
-1
3
coa
1
3
ppap
1
3
ribokinase (RBK)
EC-2.7.1.15
0
atp
-1
3
rib-D
-1
3
adp
1
3
h
1
3
r5p
1
3
L-rhamnose isomerase (RMI)
EC-5.3.1.14
1
rmn
-1
3
rml
1
3
rhamnulokinase (RMK)
EC-2.7.1.5
0
atp
-1
3
rml
-1
3
adp
1
3
h
1
3
rml1p
1
3
Rhamnulose-1-phosphate aldolase (RMPA)
EC-4.1.2.19
1
rml1p
-1
3
dhap
1
3
lald-L
1
3
Methylmalonyl-CoA mutase (MMM2)
EC-5.4.99.2
0
succoa
-1
3
mmcoa-R
1
3
3-keto-L-gulonate 6-phosphate decarboxylase (KG6PDC)
0
3dgulnp
-1
3
h
-1
3
co2
1
3
xu5p-L
1
3
L-xylulose 5-phosphate 3-epimerase (X5PL3E)
0
xu5p-L
-1
3
ru5p-L
1
3
sorbitol-6-phosphate dehydrogenase (SBTPD)
EC-1.1.1.140
1
nad
-1
3
sbt6p
-1
3
f6p
1
3
h
1
3
nadh
1
3
Taurine dioxygenase (TAUDO)
EC-1.14.11.17
0
akg
-1
3
o2
-1
3
taur
-1
3
aacald
1
3
co2
1
3
h
1
3
so3
1
3
succ
1
3
Propionate kinase (PPAKr)
1
adp
-1
3
ppap
-1
3
atp
1
3
ppa
1
3
2-Oxobutanoate formate lyase (OBTFL)
0
2obut
-1
3
coa
-1
3
for
1
3
ppcoa
1
3
alpha,alpha-trehalase (TREHe)
EC-3.2.1.28
0
h2o
-1
1
tre
-1
1
glc-D
2
1
trehalose-6-phosphate hydrolase (TRE6PH)
EC-3.2.1.93
0
h2o
-1
3
tre6p
-1
3
g6p
1
3
glc-D
1
3
alpha,alpha-trehalase (TREH)
EC-3.2.1.28
0
h2o
-1
3
tre
-1
3
glc-D
2
3
L(+)-tartrate dehydratase (TARTD)
EC-4.2.1.32
0
tartr-L
-1
3
h2o
1
3
oaa
1
3
Phenethylamine oxidase (PEAMNO)
EC-1.4.3.6
0
h2o
-1
3
o2
-1
3
peamn
-1
3
h2o2
1
3
nh4
1
3
pacald
1
3
altronate hydrolase (ALTRH)
EC-4.2.1.7
0
altrn
-1
3
2ddglcn
1
3
h2o
1
3
tagaturonate reductase (TAGURr)
EC-1.1.1.58
1
altrn
-1
3
nad
-1
3
h
1
3
nadh
1
3
tagur
1
3
glucuronate isomerase (D-glucuronate) (GUI1)
EC-5.3.1.12
1
glcur
-1
3
fruur
1
3
glucuronate isomerase (D-galacturonate) (GUI2)
EC-5.3.1.12
1
galur
-1
3
tagur
1
3
D-mannonate hydrolyase (MNNH)
EC-4.2.1.8
0
mana
-1
3
2ddglcn
1
3
h2o
1
3
Mannonate oxidoreductase (MANAO)
EC-1.1.1.57
1
mana
-1
3
nad
-1
3
fruur
1
3
h
1
3
nadh
1
3
xylose isomerase (XYLI2i)
EC-5.3.1.5
0
fru
-1
3
glc-D
1
3
xylose isomerase (XYLI1)
EC-5.3.1.5
1
xyl-D
-1
3
xylu-D
1
3
xylulokinase (XYLK)
EC-2.7.1.17
0
atp
-1
3
xylu-D
-1
3
adp
1
3
h
1
3
xu5p-D
1
3
2,5-diketo-D-gluconate reductase (DKGLCNR1)
0
25dkglcn
-1
3
h
-1
3
nadph
-1
3
2dhguln
1
3
nadp
1
3
Hydroxypyruvate reductase (NADH) (HPYRRx)
0
h
-1
3
hpyr
-1
3
nadh
-1
3
glyc-R
1
3
nad
1
3
Hydroxypyruvate reductase (NADPH) (HPYRRy)
0
h
-1
3
hpyr
-1
3
nadph
-1
3
glyc-R
1
3
nadp
1
3
glucarate dehydratase (GLCRD)
EC-4.2.1.40
0
glcr
-1
3
5dh4dglc
1
3
h2o
1
3
Methylmalonyl-CoA decarboxylase (MMCD)
EC-4.1.1.41
0
h
-1
3
mmcoa-S
-1
3
co2
1
3
ppcoa
1
3
Propanoyl-CoA: succinate CoA-transferase (PPCSCT)
0
ppcoa
-1
3
succ
-1
3
ppa
1
3
succoa
1
3
2,5-diketo-D-gluconate reductase (NADPH) (DKGLCNR2y)
0
25dkglcn
-1
3
h
-1
3
nadph
-1
3
5dglcn
1
3
nadp
1
3
2-dehydro-D-gluconate reductase (NADH) (2DGLCNRx)
0
2dhglcn
-1
3
h
-1
3
nadh
-1
3
glcn
1
3
nad
1
3
2-dehydro-D-gluconate reductase (NADPH) (2DGLCNRy)
EC-1.1.1.215
0
2dhglcn
-1
3
h
-1
3
nadph
-1
3
glcn
1
3
nadp
1
3
2,5-diketo-D-gluconate reductase (NADH) (DKGLCNR2x)
0
25dkglcn
-1
3
h
-1
3
nadh
-1
3
5dglcn
1
3
nad
1
3
2-dehydro-L-gulonate reductase (NADH) (2DGULRx)
0
2dhguln
-1
3
h
-1
3
nadh
-1
3
idon-L
1
3
nad
1
3
2-dehydro-L-gulonate reductase (NADPH) (2DGULRy)
0
2dhguln
-1
3
h
-1
3
nadph
-1
3
idon-L
1
3
nadp
1
3
2,3 dioxo-L-gulonate reductase (DOGULNR)
0
23doguln
-1
3
h
-1
3
nadh
-1
3
3dhguln
1
3
nad
1
3
Anaplerotic reactions
Isocitrate lyase (ICL)
EC-4.1.3.1
0
icit
-1
3
glx
1
3
succ
1
3
malate synthase (MALS)
EC-4.1.3.2
0
accoa
-1
3
glx
-1
3
h2o
-1
3
coa
1
3
h
1
3
mal-L
1
3
malic enzyme (NADP) (ME2)
EC-1.1.1.40
0
mal-L
-1
3
nadp
-1
3
co2
1
3
nadph
1
3
pyr
1
3
phosphoenolpyruvate carboxykinase (PPCK)
EC-4.1.1.49
0
atp
-1
3
oaa
-1
3
adp
1
3
co2
1
3
pep
1
3
inorganic diphosphatase (PPA)
EC-3.6.1.1
0
h2o
-1
3
ppi
-1
3
h
1
3
pi
2
3
phosphoenolpyruvate carboxylase (PPC)
EC-4.1.1.31
0
co2
-1
3
h2o
-1
3
pep
-1
3
h
1
3
oaa
1
3
pi
1
3
malic enzyme (NAD) (ME1)
EC-1.1.1.38
0
mal-L
-1
3
nad
-1
3
co2
1
3
nadh
1
3
pyr
1
3
Arginine and Proline Metabolism
5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase (MDRPD)
0
5mdru1p
-1
3
dkmpp
1
3
h2o
1
3
2,3-diketo-5-methylthio-1-phosphopentane degradation reaction (DKMPPD2)
0
dkmpp
-1
3
h2o
-3
3
2kmb
1
3
for
1
3
h
6
3
pi
1
3
Putrescine Transaminase (PTRCTA)
0
akg
-1
3
ptrc
-1
3
4abutn
1
3
glu-L
1
3
succinate-semialdehyde dehydrogenase (NAD) (SSALx)
EC-1.2.1.16
0
h2o
-1
3
nad
-1
3
sucsal
-1
3
h
2
3
nadh
1
3
succ
1
3
Aminobutyraldehyde dehydrogenase (ABUTD)
EC-1.2.1.19
0
4abutn
-1
3
h2o
-1
3
nad
-1
3
4abut
1
3
h
2
3
nadh
1
3
5-methylthioribose kinase (MTRK)
EC-2.7.1.100
0
5mtr
-1
3
atp
-1
3
5mdr1p
1
3
adp
1
3
h
1
3
5-methylthioribose-1-phosphate isomerase (MTRI)
EC-5.3.1.23
1
5mdr1p
-1
3
5mdru1p
1
3
2,3-diketo-5-methylthio-1-phosphopentane degradation reaction (DKMPPD)
0
dkmpp
-1
3
h2o
-1
3
o2
-1
3
2kmb
1
3
for
1
3
h
2
3
pi
1
3
L-glutamate 5-semialdehyde dehydratase (spontaneous) (G5SADs)
0
glu5sa
-1
3
1pyr5c
1
3
h
1
3
h2o
1
3
2-keto-4-methylthiobutyrate transamination (UNK3)
0
2kmb
-1
3
glu-L
-1
3
akg
1
3
met-L
1
3
N-acetylglutamate synthase (ACGS)
EC-2.3.1.1
0
accoa
-1
3
glu-L
-1
3
acglu
1
3
coa
1
3
h
1
3
acetylglutamate kinase (ACGK)
EC-2.7.2.8
0
acglu
-1
3
atp
-1
3
acg5p
1
3
adp
1
3
N-acetyl-g-glutamyl-phosphate reductase (AGPR)
EC-1.2.1.38
1
acg5sa
-1
3
nadp
-1
3
pi
-1
3
acg5p
1
3
h
1
3
nadph
1
3
acetylornithine transaminase (ACOTA)
EC-2.6.1.11
1
acorn
-1
3
akg
-1
3
acg5sa
1
3
glu-L
1
3
N-acetylornithine deacetylase (NACODA)
0
acg5sa
-1
3
h2o
-1
3
ac
1
3
glu5sa
1
3
acetylornithine deacetylase (ACODA)
EC-3.5.1.16
0
acorn
-1
3
h2o
-1
3
ac
1
3
orn
1
3
argininosuccinate synthase (ARGSS)
EC-6.3.4.5
0
asp-L
-1
3
atp
-1
3
citr-L
-1
3
amp
1
3
argsuc
1
3
h
1
3
ppi
1
3
argininosuccinate lyase (ARGSL)
EC-4.3.2.1
1
argsuc
-1
3
arg-L
1
3
fum
1
3
ornithine carbamoyltransferase (OCBT)
EC-2.1.3.3
1
cbp
-1
3
orn
-1
3
citr-L
1
3
h
1
3
pi
1
3
Arginine succinyltransferase (AST)
EC-2.3.1.109
0
arg-L
-1
3
succoa
-1
3
coa
1
3
h
1
3
sucarg
1
3
Succinylornithine transaminase (SOTA)
0
akg
-1
3
sucorn
-1
3
glu-L
1
3
sucgsa
1
3
Succinylarginine dihydrolase (SADH)
EC-2.6.1.69
0
h
-2
3
h2o
-2
3
sucarg
-1
3
co2
1
3
nh4
2
3
sucorn
1
3
Succinylglutamic semialdehyde dehydrogenase (SGSAD)
0
h2o
-1
3
nad
-1
3
sucgsa
-1
3
h
2
3
nadh
1
3
sucglu
1
3
Succinylglutamate desuccinylase (SGDS)
0
h2o
-1
3
sucglu
-1
3
glu-L
1
3
succ
1
3
carbamoyl-phosphate synthase (glutamine-hydrolysing) (CBPS)
EC-6.3.5.5
0
atp
-2
3
gln-L
-1
3
h2o
-1
3
hco3
-1
3
adp
2
3
cbp
1
3
glu-L
1
3
h
2
3
pi
1
3
succinate-semialdehyde dehydrogenase (NADP) (SSALy)
EC-1.2.1.16
0
h2o
-1
3
nadp
-1
3
sucsal
-1
3
h
2
3
nadph
1
3
succ
1
3
4-aminobutyrate transaminase (ABTA)
EC-2.6.1.19
0
4abut
-1
3
akg
-1
3
glu-L
1
3
sucsal
1
3
Glutathionylspermidine amidase (GSPMDA)
EC-3.5.1.78
0
gtspmd
-1
3
h2o
-1
3
gthrd
1
3
spmd
1
3
Glutathionylspermidine synthetase (GSPMDS)
EC-6.3.1.8
0
atp
-1
3
gthrd
-1
3
spmd
-1
3
adp
1
3
gtspmd
1
3
h
1
3
pi
1
3
methylthioadenosine nucleosidase (MTAN)
EC-3.2.2.16
0
5mta
-1
3
h2o
-1
3
5mtr
1
3
ade
1
3
glutamate-5-semialdehyde dehydrogenase (G5SD)
EC-1.2.1.41
0
glu5p
-1
3
h
-1
3
nadph
-1
3
glu5sa
1
3
nadp
1
3
pi
1
3
glutamate 5-kinase (GLU5K)
EC-2.7.2.11
0
atp
-1
3
glu-L
-1
3
adp
1
3
glu5p
1
3
pyrroline-5-carboxylate reductase (P5CR)
EC-1.5.1.2
0
1pyr5c
-1
3
h
-2
3
nadph
-1
3
nadp
1
3
pro-L
1
3
1-pyrroline-5-carboxylate dehydrogenase (P5CD)
EC-1.5.1.12
0
1pyr5c
-1
3
h2o
-2
3
nad
-1
3
glu-L
1
3
h
1
3
nadh
1
3
Proline dehydrogenase (PROD2)
EC-1.5.99.8
0
fad
-1
3
pro-L
-1
3
1pyr5c
1
3
fadh2
1
3
h
1
3
arginine decarboxylase (ARGDC)
EC-4.1.1.19
0
arg-L
-1
3
h
-1
3
agm
1
3
co2
1
3
agmatinase (AGMT)
EC-3.5.3.11
0
agm
-1
3
h2o
-1
3
ptrc
1
3
urea
1
3
Ornithine Decarboxylase (ORNDC)
EC-4.1.1.17
0
h
-1
3
orn
-1
3
co2
1
3
ptrc
1
3
Adenosylmethionine decarboxylase (ADMDCr)
EC-4.1.1.50
1
amet
-1
3
h
-1
3
ametam
1
3
co2
1
3
spermidine synthase (SPMS)
EC-2.5.1.16
0
ametam
-1
3
ptrc
-1
3
5mta
1
3
h
1
3
spmd
1
3
Spermidine acetyltransferase (SPMDAT1)
EC-2.3.1.57
0
accoa
-1
3
spmd
-1
3
N1aspmd
1
3
coa
1
3
h
1
3
Spermidine acetyltransferase (N8) (SPMDAT2)
EC-2.3.1.57
0
accoa
-1
3
spmd
-1
3
coa
1
3
h
1
3
n8aspmd
1
3
ornithine transaminase (ORNTA)
EC-2.6.1.13
0
akg
-1
3
orn
-1
3
glu-L
1
3
glu5sa
1
3
Cell Envelope Biosynthesis
Peptidoglycan subunit synthesis (PPTGS)
0
uaagmda
-1
3
h
1
3
peptido_EC
1
3
udcpdp
1
3
undecaprenyl-diphosphatase (UDCPDP)
EC-3.6.1.27
0
h2o
-1
3
udcpdp
-1
3
h
1
3
pi
1
3
udcpp
1
3
3-deoxy-manno-octulosonate-8-phosphatase (KDOPP)
EC-3.1.3.45
0
h2o
-1
3
kdo8p
-1
3
kdo
1
3
pi
1
3
ethanolamine phosphotransferase (PEPT_EC)
EC-2.7.8.1
1
cmp
-1
3
h
-1
3
pe_EC
-0.02
3
12dgr_EC
0.02
3
cdpea
1
3
Phosphatidate phosphatase (PAPA_EC)
EC-3.1.3.4
0
h2o
-1
3
pa_EC
-0.02
3
12dgr_EC
0.02
3
pi
1
3
ECA polymerization (Ecoli) (ECAP_EC)
0
unagamuf
-1
3
eca_EC
1
3
h
1
3
udcpdp
1
3
acyl-[acyl-carrier-protein] synthetase (n-C14:0) (AACPS1)
EC-6.2.1.20
0
ACP
-1
3
atp
-1
3
ttdca
-1
3
amp
1
3
myrsACP
1
3
ppi
1
3
acyl-[acyl-carrier-protein] synthetase (n-C14:1) (AACPS2)
EC-6.2.1.20
0
ACP
-1
3
atp
-1
3
ttdcea
-1
3
amp
1
3
ppi
1
3
tdeACP
1
3
acyl-[acyl-carrier-protein] synthetase (n-C16:0) (AACPS3)
EC-6.2.1.20
0
ACP
-1
3
atp
-1
3
hdca
-1
3
amp
1
3
palmACP
1
3
ppi
1
3
acyl-[acyl-carrier-protein] synthetase (n-C16:1) (AACPS4)
EC-6.2.1.20
0
ACP
-1
3
atp
-1
3
hdcea
-1
3
amp
1
3
hdeACP
1
3
ppi
1
3
acyl-[acyl-carrier-protein] synthetase (n-C18:1) (AACPS5)
EC-6.2.1.20
0
ACP
-1
3
atp
-1
3
ocdcea
-1
3
amp
1
3
octeACP
1
3
ppi
1
3
D-alanine-D-alanine ligase (reversible) (ALAALAr)
EC-6.3.2.4
1
ala-D
-2
3
atp
-1
3
adp
1
3
alaala
1
3
h
1
3
pi
1
3
Diacylglycerol kinase (DAGK_EC)
EC-2.7.1.107
0
12dgr_EC
-0.02
3
atp
-1
3
adp
1
3
h
1
3
pa_EC
0.02
3
Ethanolamine ammonia-lyase (ETHAAL)
EC-4.3.1.7
0
etha
-1
3
acald
1
3
nh4
1
3
GDP-4-dehydro-6-deoxy-D-mannose epimerase (GDMANE)
0
gdpddman
-1
3
gdpofuc
1
3
GDP-4-oxo-L-fucose reductase (GOFUCR)
0
gdpofuc
-1
3
h
-1
3
nadph
-1
3
gdpfuc
1
3
nadp
1
3
UTP-glucose-1-phosphate uridylyltransferase (irreversible) (GALUi)
EC-2.7.7.9
0
g1p
-1
3
h
-1
3
utp
-1
3
ppi
1
3
udpg
1
3
UDPgalactopyranose mutase (UDPGALM)
EC-5.4.99.9
0
udpgal
-1
3
udpgalfur
1
3
glutamine-fructose-6-phosphate transaminase (GF6PTA)
EC-2.6.1.16
0
f6p
-1
3
gln-L
-1
3
gam6p
1
3
glu-L
1
3
UDP-N-acetylglucosamine diphosphorylase (UAGDP)
EC-2.7.7.23
0
acgam1p
-1
3
h
-1
3
utp
-1
3
ppi
1
3
uacgam
1
3
glucosamine-1-phosphate N-acetyltransferase (G1PACT)
EC-2.3.1.157
0
accoa
-1
3
gam1p
-1
3
acgam1p
1
3
coa
1
3
h
1
3
Glycerophosphodiester phosphodiesterase (Glycerophosphocholine) (GPDDA1)
EC-3.1.4.46
0
g3pc
-1
3
h2o
-1
3
chol
1
3
glyc3p
1
3
h
1
3
Glycerophosphodiester phosphodiesterase (Glycerophosphoethanolamine) (GPDDA2)
EC-3.1.4.46
0
g3pe
-1
3
h2o
-1
3
etha
1
3
glyc3p
1
3
h
1
3
Glycerophosphodiester phosphodiesterase (Glycerophosphoserine) (GPDDA3)
EC-3.1.4.46
0
g3ps
-1
3
h2o
-1
3
glyc3p
1
3
h
1
3
ser-L
1
3
Glycerophosphodiester phosphodiesterase (Glycerophosphoglycerol) (GPDDA4)
EC-3.1.4.46
0
g3pg
-1
3
h2o
-1
3
glyc
1
3
glyc3p
1
3
h
1
3
Glycerophosphodiester phosphodiesterase (Glycerophosphoinositol) (GPDDA5)
EC-3.1.4.46
0
g3pi
-1
3
h2o
-1
3
glyc3p
1
3
h
1
3
inost
1
3
GDP-D-mannose dehydratase (GMAND)
EC-4.2.1.47
0
gdpmann
-1
3
gdpddman
1
3
h2o
1
3
sedoheptulose 7-phosphate isomerase (S7PI)
0
s7p
-1
3
gmhep7p
1
3
D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase (GMHEPPA)
0
gmhep17bp
-1
3
h2o
-1
3
gmhep1p
1
3
pi
1
3
3-deoxy -D-manno-octulosonic -acid 8-phosphate (KDOPS)
EC-4.1.2.16
0
ara5p
-1
3
h2o
-1
3
pep
-1
3
kdo8p
1
3
pi
1
3
3-deoxy-manno-octulosonate cytidylyltransferase (KDOCT2)
EC-2.7.7.38
0
ctp
-1
3
kdo
-1
3
ckdo
1
3
ppi
1
3
3-deoxy-D-manno-octulosonic acid transferase (MOAT)
0
ckdo
-1
3
lipidA
-1
3
cmp
1
3
h
1
3
kdolipid4
1
3
3-deoxy-D-manno-octulosonic acid transferase (MOAT2)
0
ckdo
-1
3
kdolipid4
-1
3
cmp
1
3
h
1
3
kdo2lipid4
1
3
UDP-N-acetylglucosamine acyltransferase (UAGAAT)
EC-2.3.1.129
1
3hmrsACP
-1
3
uacgam
-1
3
ACP
1
3
u3aga
1
3
Lipid A disaccaride synthase (LPADSS)
EC-2.4.1.182
0
lipidX
-1
3
u23ga
-1
3
h
1
3
lipidAds
1
3
udp
1
3
UDP-3-O-acetylglucosamine deacetylase (UHGADA)
0
h2o
-1
3
u3aga
-1
3
ac
1
3
u3hga
1
3
UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase (U23GAAT)
0
3hmrsACP
-1
3
u3hga
-1
3
ACP
1
3
h
1
3
u23ga
1
3
Tetraacyldisaccharide 4'kinase (TDSK)
EC-2.7.1.130
0
atp
-1
3
lipidAds
-1
3
adp
1
3
h
1
3
lipidA
1
3
Endotoxin Synthesis (lauroyl transferase) (EDTXS1)
0
ddcaACP
-1
3
kdo2lipid4
-1
3
ACP
1
3
kdo2lipid4L
1
3
Endotoxin Synthesis (palmitoleoyl ACP) (EDTXS3)
0
hdeACP
-1
3
kdo2lipid4
-1
3
ACP
1
3
kdo2lipid4p
1
3
mannose-1-phosphate guanylyltransferase (GDP) (MAN1PT2)
EC-2.7.7.22
0
gdp
-1
3
h
-1
3
man1p
-1
3
gdpmann
1
3
pi
1
3
phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate) (PAPPT3)
EC-2.7.8.13
0
udcpp
-1
3
ugmda
-1
3
uagmda
1
3
ump
1
3
phosphoglucosamine mutase (PGAMT)
EC-5.4.2.10
1
gam1p
-1
3
gam6p
1
3
Endotoxin Synthesis (myristoyl transferase) (EDTXS4)
0
kdo2lipid4p
-1
3
myrsACP
-1
3
ACP
1
3
lipa_cold
1
3
Endotoxin Synthesis (myristoyl transferase) (EDTXS2)
0
kdo2lipid4L
-1
3
myrsACP
-1
3
ACP
1
3
lipa
1
3
UDP-N-acetylglucosamine 1-carboxyvinyltransferase (UAGCVT)
EC-2.5.1.7
0
pep
-1
3
uacgam
-1
3
pi
1
3
uaccg
1
3
UDP-N-acetylenolpyruvoylglucosamine reductase (UAPGR)
EC-1.1.1.158
0
h
-1
3
nadph
-1
3
uaccg
-1
3
nadp
1
3
uamr
1
3
UDP-N-acetylmuramoyl-L-alanine synthetase (UAMAS)
EC-6.3.2.8
0
ala-L
-1
3
atp
-1
3
uamr
-1
3
adp
1
3
h
1
3
pi
1
3
uama
1
3
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase (UAMAGS)
EC-6.3.2.9
0
atp
-1
3
glu-D
-1
3
uama
-1
3
adp
1
3
h
1
3
pi
1
3
uamag
1
3
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase (UAAGDS)
EC-6.3.2.13
0
26dap-M
-1
3
atp
-1
3
uamag
-1
3
adp
1
3
h
1
3
pi
1
3
ugmd
1
3
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase (UGMDDS)
EC-6.3.2.15
0
alaala
-1
3
atp
-1
3
ugmd
-1
3
adp
1
3
h
1
3
pi
1
3
ugmda
1
3
UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (UAGPT3)
0
uacgam
-1
3
uagmda
-1
3
h
1
3
uaagmda
1
3
udp
1
3
glutamate racemase (GLUR)
EC-5.1.1.3
1
glu-D
-1
3
glu-L
1
3
Phospholipase A (phosphatidylcholine) (PLIPA3)
0
h2o
-1
3
pc_EC
-0.02
3
agpc_EC
0.02
3
h
1
3
hdca
0.36
3
hdcea
0.07
3
ocdcea
0.5
3
ttdca
0.02
3
ttdcea
0.05
3
Phospholipase A (phosphatidylglycerol) (PLIPA1)
0
h2o
-1
3
pg_EC
-0.02
3
agpg_EC
0.02
3
h
1
3
hdca
0.36
3
hdcea
0.07
3
ocdcea
0.5
3
ttdca
0.02
3
ttdcea
0.05
3
Phosphlipase A (phosphatidylethanolamine) (PLIPA2)
0
h2o
-1
3
pe_EC
-0.02
3
agpe_EC
0.02
3
h
1
3
hdca
0.36
3
hdcea
0.07
3
ocdcea
0.5
3
ttdca
0.02
3
ttdcea
0.05
3
Lysophospholipase L (acyl-glycerophosphoglycerol) (LPLIPA1)
0
agpg_EC
-0.02
3
h2o
-1
3
g3pg
1
3
h
1
3
hdca
0.36
3
hdcea
0.07
3
ocdcea
0.5
3
ttdca
0.02
3
ttdcea
0.05
3
Lysophospholipase L (acyl-glycerophosphoethanolamine) (LPLIPA2)
0
agpe_EC
-0.02
3
h2o
-1
3
g3pe
1
3
h
1
3
hdca
0.36
3
hdcea
0.07
3
ocdcea
0.5
3
ttdca
0.02
3
ttdcea
0.05
3
Lysophospholipase L (acyl-glycerophosphocholinel) (LPLIPA3)
0
agpc_EC
-0.02
3
h2o
-1
3
g3pc
1
3
h
1
3
hdca
0.36
3
hdcea
0.07
3
ocdcea
0.5
3
ttdca
0.02
3
ttdcea
0.05
3
Lysophospholipase L (acyl transfer to phosphatidylglycerol) (LPLIPA4)
0
agpe_EC
-0.02
3
pg_EC
-0.02
3
apg_EC
0.02
3
g3pe
1
3
Lysophospholipase L (acyl transfer to phosphatidylglycerol) (LPLIPA5)
0
agpc_EC
-0.02
3
pg_EC
-0.02
3
apg_EC
0.02
3
g3pc
1
3
Lysophospholipase L (acyl transfer to phosphatidylglycerol) (LPLIPA6)
0
agpg_EC
-0.02
3
pg_EC
-0.02
3
apg_EC
0.02
3
g3pg
1
3
ADP-D-glycero-D-manno-heptose epimerase (AGMHE)
EC-5.1.3.20
0
adphep-D,D
-1
3
adphep-L,D
1
3
D-glycero-D-manno-hepose 1-phosphate adenyltransferase (GMHEPAT)
0
atp
-1
3
gmhep1p
-1
3
h
-1
3
adphep-D,D
1
3
ppi
1
3
D-glycero-D-manno-heptose 7-phosphate kinase (GMHEPK)
0
atp
-1
3
gmhep7p
-1
3
adp
1
3
gmhep17bp
1
3
h
1
3
Lipopolysaccharide synthesis (Ecoli) (LPSSYN_EC)
0
adphep-L,D
-3
3
cdpea
-2
3
ckdo
-3
3
lipa
-1
3
udpg
-2
3
adp
3
3
cdp
2
3
cmp
3
3
h
10
3
lps_EC
1
3
udp
2
3
glucose-1-phosphate thymidylyltransferase (G1PTT)
EC-2.7.7.24
0
dttp
-1
3
g1p
-1
3
h
-1
3
dtdpglu
1
3
ppi
1
3
dTDPglucose 4,6-dehydratase (TDPGDH)
EC-4.2.1.46
0
dtdpglu
-1
3
dtdp4d6dg
1
3
h2o
1
3
dTDP-4-dehydrorhamnose 3,5-epimerase (TDPDRE)
EC-5.1.3.13
0
dtdp4d6dg
-1
3
dtdp4d6dm
1
3
dTDP-4-dehydrorhamnose reductase (TDPDRR)
EC-1.1.1.133
0
dtdp4d6dm
-1
3
h
-1
3
nadph
-1
3
dtdprmn
1
3
nadp
1
3
myo-inositol 1-phosphatase (MI1PP)
EC-3.1.3.25
0
h2o
-1
3
mi1p-D
-1
3
inost
1
3
pi
1
3
UDPglucose 6-dehydrogenase (UDPGD)
EC-1.1.1.22
0
h2o
-1
3
nad
-2
3
udpg
-1
3
h
3
3
nadh
2
3
udpglcur
1
3
UDP-sugar hydrolase (USHD)
0
h2o
-1
3
u23ga
-1
3
h
2
3
lipidX
1
3
ump
1
3
UDP-N-acetylglucosamine:undecaprenylphosphate N-acetylglucosamine -1-phosphate transferase (ACGAMT)
0
uacgam
-1
3
udcpp
-1
3
ump
1
3
unaga
1
3
UDP-N-acetylglucosamine 2-epimerase (UAG2Ei)
EC-5.1.3.14
0
uacgam
-1
3
uacmam
1
3
UDP-N-acetyl-D-mannosamine oxidoreductase (UACMAMO)
0
h2o
-1
3
nad
-2
3
uacmam
-1
3
h
3
3
nadh
2
3
uacmamu
1
3
dTDP-4-amino-4,6-dideoxy-D-glucose acetyltransferase (TDPADGAT)
0
accoa
-1
3
dtdp4addg
-1
3
coa
1
3
dtdp4aaddg
1
3
h
1
3
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase (TDPAGTA)
EC-2.6.1.33
0
dtdp4d6dg
-1
3
glu-L
-1
3
akg
1
3
dtdp4addg
1
3
dTDP-N-4-acetamido-4,6-dideoxy-D-galactose transferase (AADDGT)
0
dtdp4aaddg
-1
3
unagamu
-1
3
dtdp
1
3
h
1
3
unagamuf
1
3
UDP-N-acetyl-D-mannosaminuronic acid transferase (ACMAMUT)
0
uacmamu
-1
3
unaga
-1
3
h
1
3
udp
1
3
unagamu
1
3
Citrate Cycle (TCA)
aconitase (ACONT)
EC-4.2.1.3
1
cit
-1
3
icit
1
3
Citrate lyase (CITL)
EC-4.1.3.6
0
cit
-1
3
ac
1
3
oaa
1
3
fumarate reductase (FRD2)
EC-1.3.99.1
0
fum
-1
3
mql8
-1
3
mqn8
1
3
succ
1
3
fumarate reductase (FRD3)
EC-1.3.99.1
0
2dmmql8
-1
3
fum
-1
3
2dmmq8
1
3
succ
1
3
fumarase (FUM)
EC-4.2.1.2
1
fum
-1
3
h2o
-1
3
mal-L
1
3
citrate synthase (CS)
EC-4.1.3.7
0
accoa
-1
3
h2o
-1
3
oaa
-1
3
cit
1
3
coa
1
3
h
1
3
isocitrate dehydrogenase (NADP) (ICDHyr)
EC-1.1.1.42
1
icit
-1
3
nadp
-1
3
akg
1
3
co2
1
3
nadph
1
3
2-Oxogluterate dehydrogenase (TEST_AKGDH)
EC-Undetermined
0
akg
-1
3
coa
-1
3
nad
-1
3
co2
1
3
nadh
1
3
succoa
1
3
malate dehydrogenase (MDH)
EC-1.1.1.37
1
mal-L
-1
3
nad
-1
3
h
1
3
nadh
1
3
oaa
1
3
Malate dehydrogenase (ubiquinone 8 as acceptor) (MDH2)
EC-1.1.99.16
0
mal-L
-1
3
q8
-1
3
oaa
1
3
q8h2
1
3
Malate dehydrogenase (menaquinone 8 as acceptor) (MDH3)
EC-1.1.99.16
0
mal-L
-1
3
mqn8
-1
3
mql8
1
3
oaa
1
3
succinate dehydrogenase (SUCD1i)
EC-1.3.99.1
0
fad
-1
3
succ
-1
3
fadh2
1
3
fum
1
3
succinyl-CoA synthetase (ADP-forming) (SUCOAS)
EC-6.2.1.5
1
atp
-1
3
coa
-1
3
succ
-1
3
adp
1
3
pi
1
3
succoa
1
3
Cofactor and Prosthetic Group Biosynthesis
pyrimidine phosphatase (PMDPHT)
0
5aprbu
-1
3
h2o
-1
3
4r5au
1
3
pi
1
3
Dihydroneopterin monophosphate dephosphorylase (DNMPPA)
0
dhpmp
-1
3
h2o
-1
3
dhnpt
1
3
pi
1
3
NADP phosphatase (NADPPPS)
0
h2o
-1
3
nadp
-1
3
nad
1
3
pi
1
3
NMN nucleosidase (NMNN)
EC-3.2.2.14
0
h2o
-1
3
nmn
-1
3
h
1
3
ncam
1
3
r5p
1
3
NAD diphosphatase (extracellular) (NADDPe)
EC-3.6.1.22
0
h2o
-1
1
nad
-1
1
amp
1
1
h
2
1
nmn
1
1
phosphopantothenoylcysteine decarboxylase (PPCDC)
EC-4.1.1.36
0
4ppcys
-1
3
h
-1
3
co2
1
3
pan4p
1
3
dephospho-CoA kinase (DPCOAK)
EC-2.7.1.24
0
atp
-1
3
dpcoa
-1
3
adp
1
3
coa
1
3
h
1
3
hypothetical enyme (HYPOE)
0
h2o
-1
3
pyam5p
-1
3
pi
1
3
pydam
1
3
Pyridoxal 5-phosphate phosphatase (PYDXPP)
0
h2o
-1
3
pydx5p
-1
3
pi
1
3
pydx
1
3
Pyridoxine 5-phosphate phosphatase (PDXPP)
0
h2o
-1
3
pdx5p
-1
3
pi
1
3
pydxn
1
3
nicotinamide-nucleotide amidase (NMNDA)
EC-3.5.1.42
0
h2o
-1
3
nmn
-1
3
nh4
1
3
nicrnt
1
3
thiamine kinase (TMKr)
EC-2.7.1.89
1
atp
-1
3
thm
-1
3
adp
1
3
h
1
3
thmmp
1
3
phosphopantothenate-cysteine ligase (PPNCL2)
EC-6.3.2.5
0
4ppan
-1
3
ctp
-1
3
cys-L
-1
3
4ppcys
1
3
cmp
1
3
h
1
3
ppi
1
3
acyl-carrier protein synthase (ACPS1)
EC-2.7.8.7
0
apoACP
-1
3
coa
-1
3
ACP
1
3
h
1
3
pap
1
3
adenosylmethionine-8-amino-7-oxononanoate transaminase (AMAOTr)
EC-2.6.1.62
1
8aonn
-1
3
amet
-1
3
amob
1
3
dann
1
3
biotin synthase (ala-L producing) (BTS2)
1
cys-L
-1
3
dtbt
-1
3
ala-L
1
3
btn
1
3
h
2
3
dethiobiotin synthase (DBTSr)
EC-6.3.3.3
1
atp
-1
3
co2
-1
3
dann
-1
3
adp
1
3
dtbt
1
3
h
3
3
pi
1
3
8-amino-7-oxononanoate synthase (AOXSr)
EC-2.3.1.47
1
ala-L
-1
3
h
-1
3
pmcoa
-1
3
8aonn
1
3
co2
1
3
coa
1
3
Biotin sulfoxide reductase (BSORx)
0
btnso
-1
3
h
-1
3
nadh
-1
3
btn
1
3
h2o
1
3
nad
1
3
Biotin sulfoxide reductase (BSORy)
0
btnso
-1
3
h
-1
3
nadph
-1
3
btn
1
3
h2o
1
3
nadp
1
3
Cobinamide adenyltransferase (CBIAT)
1
atp
-1
3
cbi
-1
3
h2o
-1
3
adocbi
1
3
pi
1
3
ppi
1
3
cob(I)alamin adenosyltransferase (CBLAT)
EC-2.5.1.17
1
atp
-1
3
cbl1
-1
3
h2o
-1
3
adocbl
1
3
pi
1
3
ppi
1
3
pantothenate kinase (PNTK)
EC-2.7.1.33
0
atp
-1
3
pnto-R
-1
3
4ppan
1
3
adp
1
3
h
1
3
pantetheine-phosphate adenylyltransferase (PTPATi)
EC-2.7.7.3
0
atp
-1
3
h
-1
3
pan4p
-1
3
dpcoa
1
3
ppi
1
3
Adenosylcobalamin 5'-phosphate synthase (ADOCBLS)
0
agdpcbi
-1
3
rdmbzi
-1
3
adocbl
1
3
gmp
1
3
h
1
3
Nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase (NNDMBRT)
0
dmbzid
-1
3
nicrnt
-1
3
5prdmbz
1
3
h
1
3
nac
1
3
Adenosyl cobinamide kinase (ADOCBIK)
0
adocbi
-1
3
atp
-1
3
adocbip
1
3
adp
1
3
h
1
3
Adenosyl cobinamide phosphate guanyltransferase (ACBIPGT)
0
adocbip
-1
3
gtp
-1
3
h
-1
3
agdpcbi
1
3
ppi
1
3
Heme O synthase (HEMEOS)
0
frdp
-1
3
h2o
-1
3
pheme
-1
3
hemeO
1
3
ppi
1
3
sirohydrochlorin dehydrogenase (NAD) (SHCHD2)
0
nad
-1
3
shcl
-1
3
h
1
3
nadh
1
3
srch
1
3
sirohydrochlorin ferrochetalase (SHCHF)
0
fe2
-1
3
srch
-1
3
h
3
3
sheme
1
3
1-deoxy-D-xylulose reductoisomerase (DXPRIi)
0
dxyl5p
-1
3
h
-1
3
nadph
-1
3
2me4p
1
3
nadp
1
3
1-deoxy-D-xylulose 5-phosphate synthase (DXPS)
0
g3p
-1
3
h
-1
3
pyr
-1
3
co2
1
3
dxyl5p
1
3
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (DHBD)
EC-1.3.1.28
1
23ddhb
-1
3
nad
-1
3
23dhb
1
3
h
1
3
nadh
1
3
isochorismatase (ICHORT)
EC-3.3.2.1
0
h2o
-1
3
ichor
-1
3
23ddhb
1
3
pyr
1
3
enterochelin synthase (ENTCS)
0
23dhba
-3
3
seramp
-3
3
amp
6
3
enter
1
3
h
6
3
2,3-dihydroxybenzoate adenylate synthase (DHBSr)
EC-2.7.7.58
1
23dhb
-1
3
atp
-1
3
23dhba
1
3
ppi
1
3
(L-seryl)adenylate synthase (SERASr)
1
atp
-1
3
h
-1
3
ser-L
-1
3
ppi
1
3
seramp
1
3
Erythrose 4-phosphate dehydrogenase (E4PD)
1
e4p
-1
3
h2o
-1
3
nad
-1
3
4per
1
3
h
2
3
nadh
1
3
dihydrofolate reductase (DHFR)
EC-1.5.1.3
1
dhf
-1
3
h
-1
3
nadph
-1
3
nadp
1
3
thf
1
3
dihydroneopterin aldolase (DHNPA2)
0
dhnpt
-1
3
6hmhpt
1
3
gcald
1
3
dihydrofolate synthase (DHFS)
EC-6.3.2.12
0
atp
-1
3
dhpt
-1
3
glu-L
-1
3
adp
1
3
dhf
1
3
pi
1
3
GTP cyclohydrolase I (GTPCI)
EC-3.5.4.16
0
gtp
-1
3
h2o
-1
3
ahdt
1
3
for
1
3
6-hydroxymethyl-dihydropterin pyrophosphokinase (HPPK2)
0
6hmhpt
-1
3
atp
-1
3
6hmhptpp
1
3
amp
1
3
h
1
3
dihydropteroate synthase (DHPS2)
0
4abz
-1
3
6hmhptpp
-1
3
dhpt
1
3
h
1
3
ppi
1
3
2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase (MECDPDH)
0
2mecdp
-1
3
h
-1
3
h2mb4p
1
3
h2o
1
3
Glutamyl-tRNA synthetase (GLUTRS)
EC-6.1.1.17
0
atp
-1
3
glu-L
-1
3
trnaglu
-1
3
amp
1
3
glutrna
1
3
ppi
1
3
D-alanine transaminase (ALATA_D2)
0
ala-D
-1
3
pydx5p
-1
3
pyam5p
1
3
pyr
1
3
alanine transaminase (ALATA_L2)
0
ala-L
-1
3
pydx5p
-1
3
pyam5p
1
3
pyr
1
3
glutathione oxidoreductase (GTHOr)
EC-1.6.4.2
1
gthox
-1
3
h
-1
3
nadph
-1
3
gthrd
2
3
nadp
1
3
gamma-glutamylcysteine synthetase (GLUCYS)
EC-6.3.2.2
0
atp
-1
3
cys-L
-1
3
glu-L
-1
3
adp
1
3
glucys
1
3
h
1
3
pi
1
3
glutathione synthetase (GTHS)
EC-6.3.2.3
0
atp
-1
3
glucys
-1
3
gly
-1
3
adp
1
3
gthrd
1
3
h
1
3
pi
1
3
glutamyl-tRNA reductase (GLUTRR)
0
glutrna
-1
3
h
-1
3
nadph
-1
3
glu1sa
1
3
nadp
1
3
trnaglu
1
3
porphobilinogen synthase (PPBNGS)
EC-4.2.1.24
0
5aop
-2
3
h
1
3
h2o
2
3
ppbng
1
3
hydroxymethylbilane synthase (HMBS)
EC-4.3.1.8
0
h2o
-1
3
ppbng
-4
3
hmbil
1
3
nh4
4
3
uroporphyrinogen-III synthase (UPP3S)
EC-4.2.1.75
0
hmbil
-1
3
h2o
1
3
uppg3
1
3
uroporphyrinogen decarboxylase (uroporphyrinogen III) (UPPDC1)
EC-4.1.1.37
0
h
-4
3
uppg3
-1
3
co2
4
3
cpppg3
1
3
coproporphyrinogen oxidase (O2 required) (CPPPGO)
EC-1.3.3.3
0
cpppg3
-1
3
h
-2
3
o2
-1
3
co2
2
3
h2o
2
3
pppg9
1
3
protoporphyrinogen oxidase (PPPGO)
EC-1.3.3.4
0
o2
-1.5
3
pppg9
-1
3
h2o
3
3
ppp9
1
3
Ferrochelatase (FCLT)
EC-4.99.1.1
0
fe2
-1
3
ppp9
-1
3
h
2
3
pheme
1
3
glutamate-1-semialdehyde aminotransferase (G1SATi)
EC-5.4.3.8
0
glu1sa
-1
3
5aop
1
3
uroporphyrinogen methyltransferase (UPP3MT)
EC-2.1.1.107
0
amet
-2
3
uppg3
-1
3
ahcys
2
3
h
1
3
shcl
1
3
isopentenyl-diphosphate D-isomerase (IPDDIi)
EC-5.3.3.2
0
ipdp
-1
3
dmpp
1
3
dimethylallyltranstransferase (DMATT)
EC-2.5.1.1
0
dmpp
-1
3
ipdp
-1
3
grdp
1
3
ppi
1
3
geranyltranstransferase (GRTT)
EC-2.5.1.10
0
grdp
-1
3
ipdp
-1
3
frdp
1
3
ppi
1
3
Octaprenyl pyrophosphate synthase (OCTDPS)
0
frdp
-1
3
ipdp
-5
3
octdp
1
3
ppi
5
3
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (MEPCT)
0
2me4p
-1
3
ctp
-1
3
h
-1
3
4c2me
1
3
ppi
1
3
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (CDPMEK)
0
4c2me
-1
3
atp
-1
3
2p4c2me
1
3
adp
1
3
h
1
3
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECDPS)
0
2p4c2me
-1
3
2mecdp
1
3
cmp
1
3
NAD diphosphatase (NADDP)
EC-3.6.1.22
0
h2o
-1
3
nad
-1
3
amp
1
3
h
2
3
nmn
1
3
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp) (DMPPS)
0
h
-1
3
h2mb4p
-1
3
nadh
-1
3
dmpp
1
3
h2o
1
3
nad
1
3
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp) (IPDPS)
0
h
-1
3
h2mb4p
-1
3
nadh
-1
3
h2o
1
3
ipdp
1
3
nad
1
3
1,4-dihydroxy-2-naphthoate octaprenyltransferase (DHNAOT)
0
dhna
-1
3
octdp
-1
3
2dmmq8
1
3
co2
1
3
h
1
3
ppi
1
3
naphthoate synthase (NPHS)
EC-4.1.3.36
0
sbzcoa
-1
3
coa
1
3
dhna
1
3
O-succinylbenzoate-CoA synthase (SUCBZS)
0
2shchc
-1
3
h2o
1
3
sucbz
1
3
2-oxoglutarate decarboxylase (OXGDC2)
EC-4.1.1.71
0
akg
-1
3
h
-1
3
thmpp
-1
3
co2
1
3
ssaltpp
1
3
2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylate synthase (SHCHCS2)
0
ichor
-1
3
ssaltpp
-1
3
2shchc
1
3
pyr
1
3
thmpp
1
3
o-succinylbenzoate-CoA ligase (SUCBZL)
EC-6.2.1.26
0
atp
-1
3
coa
-1
3
sucbz
-1
3
amp
1
3
ppi
1
3
sbzcoa
1
3
Isochorismate Synthase (ICHORSi)
0
chor
-1
3
ichor
1
3
S-adenosylmethione:2-demethylmenaquinone methyltransferase (AMMQT8_2)
0
2dmmq8
-1
3
amet
-1
3
ahcys
1
3
h
1
3
mqn8
1
3
quinolinate synthase (QULNS)
0
dhap
-1
3
iasp
-1
3
h
1
3
h2o
2
3
pi
1
3
quln
1
3
L-aspartate oxidase (ASPO3)
0
asp-L
-1
3
q8
-1
3
iasp
1
3
q8h2
1
3
L-aspartate oxidase (ASPO4)
0
asp-L
-1
3
mqn8
-1
3
iasp
1
3
mql8
1
3
L-aspartate oxidase (ASPO5)
0
asp-L
-1
3
fum
-1
3
iasp
1
3
succ
1
3
L-aspartate oxidase (ASPO6)
0
asp-L
-1
3
o2
-1
3
h2o2
1
3
iasp
1
3
nicotinate-nucleotide diphosphorylase (carboxylating) (NNDPR)
EC-2.4.2.19
0
h
-2
3
prpp
-1
3
quln
-1
3
co2
1
3
nicrnt
1
3
ppi
1
3
nicotinate-nucleotide adenylyltransferase (NNAT)
EC-2.7.7.18
0
atp
-1
3
h
-1
3
nicrnt
-1
3
dnad
1
3
ppi
1
3
nicotinamide-nucleotide adenylyltransferase (NMNAT)
EC-2.7.7.1
0
atp
-1
3
h
-1
3
nmn
-1
3
nad
1
3
ppi
1
3
NAD synthase (nh3) (NADS1)
EC-6.3.1.5
0
atp
-1
3
dnad
-1
3
nh4
-1
3
amp
1
3
h
1
3
nad
1
3
ppi
1
3
Dihydroneopterin triphosphate pyrophosphatase (DNTPPA)
0
ahdt
-1
3
h2o
-1
3
dhpmp
1
3
h
1
3
ppi
1
3
4-amino-4-deoxychorismate synthase (ADCS)
0
chor
-1
3
gln-L
-1
3
4adcho
1
3
glu-L
1
3
4-aminobenzoate synthase (ADCL)
0
4adcho
-1
3
4abz
1
3
h
1
3
pyr
1
3
3-methyl-2-oxobutanoate hydroxymethyltransferase (MOHMT)
EC-2.1.2.11
0
3mob
-1
3
h2o
-1
3
mlthf
-1
3
2dhp
1
3
thf
1
3
pantothenate synthase (PANTS)
EC-6.3.2.1
0
ala-B
-1
3
atp
-1
3
pant-R
-1
3
amp
1
3
h
1
3
pnto-R
1
3
ppi
1
3
aspartate 1-decarboxylase (ASP1DC)
EC-4.1.1.11
0
asp-L
-1
3
h
-1
3
ala-B
1
3
co2
1
3
2-dehydropantoate 2-reductase (DPR)
EC-1.1.1.169
0
2dhp
-1
3
h
-1
3
nadph
-1
3
nadp
1
3
pant-R
1
3
Pyridoxine 5'-phosphate synthase (PDX5PS)
0
dxyl5p
-1
3
nad
-1
3
phthr
-1
3
co2
1
3
h
1
3
h2o
2
3
nadh
1
3
pdx5p
1
3
pi
1
3
Erythronate 4-phosphate (4per) dehydrogenase (PERD)
1
4per
-1
3
nad
-1
3
h
1
3
nadh
1
3
ohpb
1
3
pyridoxine 5'-phosphate oxidase (PDX5PO)
EC-1.4.3.5
1
o2
-1
3
pdx5p
-1
3
h2o2
1
3
pydx5p
1
3
pyridoxamine 5'-phosphate oxidase (PYAM5PO)
EC-1.4.3.5
0
h2o
-1
3
o2
-1
3
pyam5p
-1
3
h2o2
1
3
nh4
1
3
pydx5p
1
3
pyridoxine kinase (PYDXNK)
EC-2.7.1.35
0
atp
-1
3
pydxn
-1
3
adp
1
3
h
1
3
pdx5p
1
3
pyridoxamine kinase (PYDAMK)
EC-2.7.1.35
0
atp
-1
3
pydam
-1
3
adp
1
3
h
1
3
pyam5p
1
3
pyridoxal kinase (PYDXK)
EC-2.7.1.35
0
atp
-1
3
pydx
-1
3
adp
1
3
h
1
3
pydx5p
1
3
alpha-ribazole 5-phosphate phosphatase (RZ5PP)
0
5prdmbz
-1
3
h2o
-1
3
pi
1
3
rdmbzi
1
3
nicotinamidase (NNAM)
EC-3.5.1.19
0
h2o
-1
3
ncam
-1
3
nac
1
3
nh4
1
3
nicotinic acid mononucleotide pyrophosphorylase (NAMNPP)
0
atp
-1
3
h2o
-1
3
nac
-1
3
prpp
-1
3
adp
1
3
nicrnt
1
3
pi
1
3
ppi
1
3
GTP cyclohydrolase II (25drapp) (GTPCII2)
0
gtp
-1
3
h2o
-3
3
25drapp
1
3
for
1
3
h
2
3
ppi
1
3
3,4-Dihydroxy-2-butanone-4-phosphate (DB4PS)
0
ru5p-D
-1
3
db4p
1
3
for
1
3
h
1
3
5-amino-6-(5-phosphoribosylamino)uracil reductase (APRAUR)
EC-1.1.1.193
0
5apru
-1
3
h
-1
3
nadph
-1
3
5aprbu
1
3
nadp
1
3
diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp) (DHPPDA2)
EC-3.5.4.26
0
25drapp
-1
3
h
-1
3
h2o
-1
3
5apru
1
3
nh4
1
3
riboflavin synthase (RBFSa)
EC-2.5.1.9
0
4r5au
-1
3
db4p
-1
3
dmlz
1
3
h2o
2
3
pi
1
3
riboflavin kinase (RBFK)
EC-2.7.1.26
0
atp
-1
3
ribflv
-1
3
adp
1
3
fmn
1
3
h
1
3
FMN adenylyltransferase (FMNAT)
EC-2.7.7.2
0
atp
-1
3
fmn
-1
3
h
-1
3
fad
1
3
ppi
1
3
riboflavin synthase (RBFSb)
EC-2.5.1.9
0
dmlz
-2
3
4r5au
1
3
ribflv
1
3
O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase (OHPBAT)
EC-2.6.1.52
1
glu-L
-1
3
ohpb
-1
3
akg
1
3
phthr
1
3
4-amino-2-methyl-5-phosphomethylpyrimidine synthetase (AMPMS)
0
air
-1
3
h2o
-1
3
4ampm
1
3
for
2
3
h
4
3
phosphomethylpyrimidine kinase (PMPK)
EC-2.7.4.7
0
4ampm
-1
3
atp
-1
3
2mahmp
1
3
adp
1
3
hydroxymethylpyrimidine kinase (ATP) (HMPK1)
EC-2.7.1.49
0
4ahmmp
-1
3
atp
-1
3
4ampm
1
3
adp
1
3
h
1
3
thiamine-phosphate diphosphorylase (TMPPP)
EC-2.5.1.3
0
2mahmp
-1
3
4mpetz
-1
3
h
-1
3
ppi
1
3
thmmp
1
3
thiamine-phosphate kinase (TMPKr)
EC-2.7.4.16
1
atp
-1
3
thmmp
-1
3
adp
1
3
thmpp
1
3
hydroxyethylthiazole kinase (HETZK)
EC-2.7.1.50
0
4mhetz
-1
3
atp
-1
3
4mpetz
1
3
adp
1
3
h
1
3
thiazole phosphate synthesis (THZPSN)
0
atp
-1
3
cys-L
-1
3
dxyl5p
-1
3
tyr-L
-1
3
4hba
1
3
4mpetz
1
3
ala-L
1
3
amp
1
3
co2
1
3
h
1
3
h2o
1
3
ppi
1
3
4-Hydroxy-L-threonine synthase (4HTHRS)
0
h2o
-1
3
phthr
-1
3
4hthr
1
3
pi
1
3
Hydroxybenzoate octaprenyltransferase (HBZOPT)
0
4hbz
-1
3
octdp
-1
3
3ophb
1
3
ppi
1
3
2-Octaprenylphenol hydroxylase (OPHHX)
0
2oph
-1
3
o2
-0.5
3
2ohph
1
3
Chorismate pyruvate lyase (CHRPL)
0
chor
-1
3
4hbz
1
3
pyr
1
3
Octaprenyl-hydroxybenzoate decarboxylase (OPHBDC)
0
3ophb
-1
3
h
-1
3
2oph
1
3
co2
1
3
2-Octaprenyl-6-methoxy-benzoquinol methylase (OMBZLM)
0
2ombzl
-1
3
amet
-1
3
2ommbl
1
3
ahcys
1
3
h
1
3
2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (OMMBLHX)
0
2ommbl
-1
3
o2
-0.5
3
2omhmbl
1
3
2-octaprenyl-6-hydroxyphenol methylase (OHPHM)
0
2ohph
-1
3
amet
-1
3
2omph
1
3
ahcys
1
3
h
1
3
3-Dimethylubiquinonol 3-methyltransferase (DMQMT)
0
2omhmbl
-1
3
amet
-1
3
ahcys
1
3
h
1
3
q8h2
1
3
2-octaprenyl-6-methoxyphenol hydroxylase (OMPHHX)
0
2omph
-1
3
o2
-0.5
3
2ombzl
1
3
Undecaprenyl diphosphate synthase (UDCPDPS)
0
frdp
-1
3
ipdp
-8
3
ppi
8
3
udcpdp
1
3
1-Deoxy-D-xylulose kinase (DXYLK)
0
atp
-1
3
dxyl
-1
3
adp
1
3
dxyl5p
1
3
h
1
3
NAD kinase (NADK)
EC-2.7.1.23
0
atp
-1
3
nad
-1
3
adp
1
3
h
1
3
nadp
1
3
Cysteine Metabolism
3',5'-bisphosphate nucleotidase (BPNT)
EC-3.1.3.7
0
h2o
-1
3
pap
-1
3
amp
1
3
pi
1
3
adenylyl-sulfate kinase (ADSK)
EC-2.7.1.25
0
aps
-1
3
atp
-1
3
adp
1
3
h
1
3
paps
1
3
Sulfate adenyltransferase (SADT2)
0
atp
-1
3
gtp
-1
3
h2o
-1
3
so4
-1
3
aps
1
3
gdp
1
3
pi
1
3
ppi
1
3
serine O-acetyltransferase (SERAT)
EC-2.3.1.30
1
accoa
-1
3
ser-L
-1
3
acser
1
3
coa
1
3
phosphoadenylyl-sulfate reductase (thioredoxin) (PAPSR)
EC-1.8.4.8
0
paps
-1
3
trdrd
-1
3
h
2
3
pap
1
3
so3
1
3
trdox
1
3
sulfite reductase (NADPH2) (SULR)
EC-1.8.2.2
1
h2o
-3
3
h2s
-1
3
nadp
-3
3
h
5
3
nadph
3
3
so3
1
3
cysteine synthase (CYSS)
EC-4.2.99.8
0
acser
-1
3
h2s
-1
3
ac
1
3
cys-L
1
3
h
1
3
Tryptophanase (L-cysteine) (TRPAS1)
EC-4.1.99.1
0
cys-L
-1
3
h2o
-1
3
h2s
1
3
nh4
1
3
pyr
1
3
Folate Metabolism
Glycolaldehyde dehydrogenase (GCALDD)
EC-1.2.1.21
0
gcald
-1
3
h2o
-1
3
nad
-1
3
glyclt
1
3
h
2
3
nadh
1
3
methenyltetrahydrofolate cyclohydrolase (MTHFC)
EC-3.5.4.9
1
h2o
-1
3
methf
-1
3
10fthf
1
3
methylenetetrahydrofolate dehydrogenase (NADP) (MTHFD)
EC-1.5.1.5
1
mlthf
-1
3
nadp
-1
3
h
1
3
methf
1
3
nadph
1
3
Glycine Cleavage System (GLYCL)
0
gly
-1
3
nad
-1
3
thf
-1
3
co2
1
3
mlthf
1
3
nadh
1
3
nh4
1
3
5,10-methylenetetrahydrofolate reductase (NADH) (MTHFR2)
0
h
-1
3
mlthf
-1
3
nadh
-1
3
5mthf
1
3
nad
1
3
formyltetrahydrofolate deformylase (FTHFD)
EC-3.5.1.10
0
10fthf
-1
3
h2o
-1
3
for
1
3
h
1
3
thf
1
3
Glutamate metabolism
Glutamate Decarboxylase (GLUDC)
EC-4.1.1.15
0
glu-L
-1
3
h
-1
3
4abut
1
3
co2
1
3
glutamate dehydrogenase (NADP) (GLUDy)
EC-1.4.1.4
1
glu-L
-1
3
h2o
-1
3
nadp
-1
3
akg
1
3
h
1
3
nadph
1
3
nh4
1
3
glutamine synthetase (GLNS)
EC-6.3.1.2
0
atp
-1
3
glu-L
-1
3
nh4
-1
3
adp
1
3
gln-L
1
3
h
1
3
pi
1
3
glutamate synthase (NADPH) (GLUSy)
EC-1.4.1.13
0
akg
-1
3
gln-L
-1
3
h
-1
3
nadph
-1
3
glu-L
2
3
nadp
1
3
glutaminase (GLUN)
EC-3.5.1.2
0
gln-L
-1
3
h2o
-1
3
glu-L
1
3
nh4
1
3
Glycine and Serine Metabolism
D-serine deaminase (SERD_D)
0
ser-D
-1
3
nh4
1
3
pyr
1
3
glycine hydroxymethyltransferase (GHMT2)
EC-2.1.2.1
0
ser-L
-1
3
thf
-1
3
gly
1
3
h2o
1
3
mlthf
1
3
glycine C-acetyltransferase (irreversible) (GLYATi)
EC-2.3.1.29
0
2aobut
-1
3
coa
-1
3
accoa
1
3
gly
1
3
phosphoglycerate dehydrogenase (PGCD)
EC-1.1.1.95
0
3pg
-1
3
nad
-1
3
3php
1
3
h
1
3
nadh
1
3
phosphoserine phosphatase (L-serine) (PSP_L)
EC-3.1.3.3
0
h2o
-1
3
pser-L
-1
3
pi
1
3
ser-L
1
3
phosphoserine transaminase (PSERT)
EC-2.6.1.52
0
3php
-1
3
glu-L
-1
3
akg
1
3
pser-L
1
3
L-serine deaminase (SERD_L)
EC-Undetermined
0
ser-L
-1
3
nh4
1
3
pyr
1
3
L-threonine dehydrogenase (THRD)
EC-1.1.1.103
0
nad
-1
3
thr-L
-1
3
2aobut
1
3
h
1
3
nadh
1
3
Glycolysis/Gluconeogenesis
pyruvate dehydrogenase (PDH)
0
coa
-1
3
nad
-1
3
pyr
-1
3
accoa
1
3
co2
1
3
nadh
1
3
Glucose-1-phosphatase (G1PP)
EC-3.1.3.10
0
g1p
-1
3
h2o
-1
3
glc-D
1
3
pi
1
3
enolase (ENO)
EC-4.2.1.11
1
2pg
-1
3
h2o
1
3
pep
1
3
fructose-bisphosphate aldolase (FBA)
EC-4.1.2.13
1
fdp
-1
3
dhap
1
3
g3p
1
3
fructose-bisphosphatase (FBP)
EC-3.1.3.11
0
fdp
-1
3
h2o
-1
3
f6p
1
3
pi
1
3
fructose 6-phosphate aldolase (F6PA)
1
f6p
-1
3
dha
1
3
g3p
1
3
glyceraldehyde-3-phosphate dehydrogenase (GAPD)
EC-1.2.1.12
1
g3p
-1
3
nad
-1
3
pi
-1
3
13dpg
1
3
h
1
3
nadh
1
3
glycogen synthase (ADPGlc) (GLCS1)
EC-2.4.1.21
0
adpglc
-1
3
adp
1
3
glycogen
1
3
h
1
3
glucose-1-phosphate adenylyltransferase (GLGC)
EC-2.7.7.27
0
atp
-1
3
g1p
-1
3
h
-1
3
adpglc
1
3
ppi
1
3
glycogen phosphorylase (GLCP)
EC-2.4.1.1
0
glycogen
-1
3
pi
-1
3
g1p
1
3
hexokinase (D-glucose:ATP) (HEX1)
EC-2.7.1.1
0
atp
-1
3
glc-D
-1
3
adp
1
3
g6p
1
3
h
1
3
phosphoglycerate mutase (PGM)
EC-5.4.2.1
1
2pg
-1
3
3pg
1
3
phosphofructokinase (PFK)
EC-2.7.1.11
0
atp
-1
3
f6p
-1
3
adp
1
3
fdp
1
3
h
1
3
glucose-6-phosphate isomerase (PGI)
EC-5.3.1.9
1
g6p
-1
3
f6p
1
3
phosphoglycerate kinase (PGK)
EC-2.7.2.3
1
3pg
-1
3
atp
-1
3
13dpg
1
3
adp
1
3
phosphoenolpyruvate synthase (PPS)
EC-2.7.9.2
0
atp
-1
3
h2o
-1
3
pyr
-1
3
amp
1
3
h
2
3
pep
1
3
pi
1
3
pyruvate kinase (PYK)
EC-2.7.1.40
0
adp
-1
3
h
-1
3
pep
-1
3
atp
1
3
pyr
1
3
triose-phosphate isomerase (TPI)
EC-5.3.1.1
1
dhap
-1
3
g3p
1
3
Glyoxylate Metabolism
tartronate semialdehyde reductase (TRSAR)
EC-1.1.1.60
0
2h3oppan
-1
3
h
-1
3
nadh
-1
3
glyc-R
1
3
nad
1
3
glyoxalate carboligase (GLXCL)
EC-4.1.1.47
0
glx
-2
3
h
-1
3
2h3oppan
1
3
co2
1
3
glycerate kinase (GLYCK)
EC-2.7.1.31
0
atp
-1
3
glyc-R
-1
3
3pg
1
3
adp
1
3
h
1
3
Glycolate dehydrogenase (NADP) (GLYCLTDy)
0
glx
-1
3
h
-1
3
nadph
-1
3
glyclt
1
3
nadp
1
3
Glycolate dehydrogenase (NAD) (GLYCLTDx)
0
glx
-1
3
h
-1
3
nadh
-1
3
glyclt
1
3
nad
1
3
Histidine Metabolism
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (irreversible) (PRMICIi)
EC-5.3.1.16
0
prfp
-1
3
prlp
1
3
imidazoleglycerol-phosphate dehydratase (IGPDH)
EC-4.2.1.19
0
eig3p
-1
3
h2o
1
3
imacp
1
3
histidinol-phosphatase (HISTP)
EC-3.1.3.15
0
h2o
-1
3
hisp
-1
3
histd
1
3
pi
1
3
histidinol-phosphate transaminase (HSTPT)
EC-2.6.1.9
0
glu-L
-1
3
imacp
-1
3
akg
1
3
hisp
1
3
histidinol dehydrogenase (HISTD)
EC-1.1.1.23
0
h2o
-1
3
histd
-1
3
nad
-2
3
h
3
3
his-L
1
3
nadh
2
3
Imidazole-glycerol-3-phosphate synthase (IG3PS)
0
gln-L
-1
3
prlp
-1
3
aicar
1
3
eig3p
1
3
glu-L
1
3
h
1
3
ATP phosphoribosyltransferase (ATPPRT)
EC-2.4.2.17
0
atp
-1
3
prpp
-1
3
ppi
1
3
prbatp
1
3
phosphoribosyl-ATP pyrophosphatase (PRATPP)
EC-3.6.1.31
0
h2o
-1
3
prbatp
-1
3
h
1
3
ppi
1
3
prbamp
1
3
phosphoribosyl-AMP cyclohydrolase (PRAMPC)
EC-3.5.4.19
0
h2o
-1
3
prbamp
-1
3
prfp
1
3
phosphoribosylpyrophosphate synthetase (PRPPS)
EC-2.7.6.1
1
atp
-1
3
r5p
-1
3
amp
1
3
h
1
3
prpp
1
3
Membrane Lipid Metabolism
acetyl-CoA carboxylate, reversible reaction (ACCOACr)
EC-6.4.1.2
1
accoa
-1
3
atp
-1
3
hco3
-1
3
adp
1
3
h
1
3
malcoa
1
3
pi
1
3
acetyl-CoA C-acetyltransferase (ACACT1r)
EC-2.3.1.9
1
accoa
-2
3
aacoa
1
3
coa
1
3
CDP-Diacylglycerol pyrophostatase (Ecoli) (CDAPPA_EC)
EC-3.6.1.26
0
cdpdag1
-0.02
3
h2o
-1
3
cmp
1
3
h
2
3
pa_EC
0.02
3
CDP-Diacylglycerol synthetase (Ecoli) (DASYN_EC)
EC-2.7.7.41
1
ctp
-1
3
h
-1
3
pa_EC
-0.02
3
cdpdag1
0.02
3
ppi
1
3
Cardiolipin Synthase (E.coli) (CLPNS_EC)
1
pg_EC
-0.04
3
clpn_EC
0.02
3
glyc
1
3
Fatty acid biosynthesis (n-C14:0) (C140SN)
0
actACP
-1
3
h
-17
3
malACP
-5
3
nadph
-12
3
ACP
5
3
co2
5
3
h2o
6
3
myrsACP
1
3
nadp
12
3
Fatty acid biosynthesis (n-C12:0) (C120SN)
0
actACP
-1
3
h
-14
3
malACP
-4
3
nadph
-10
3
ACP
4
3
co2
4
3
ddcaACP
1
3
h2o
5
3
nadp
10
3
Malonyl-ACP decarboxylase (MACPD)
0
h
-1
3
malACP
-1
3
acACP
1
3
co2
1
3
b-ketoacyl synthase (KAS14)
0
acACP
-1
3
h
-1
3
malACP
-1
3
ACP
1
3
actACP
1
3
co2
1
3
Malonyl-CoA-ACP transacylase (MCOATA)
EC-2.3.1.39
1
ACP
-1
3
malcoa
-1
3
coa
1
3
malACP
1
3
Fatty acid biosynthesis (n-C16:0) (C160SN)
0
actACP
-1
3
h
-20
3
malACP
-6
3
nadph
-14
3
ACP
6
3
co2
6
3
h2o
7
3
nadp
14
3
palmACP
1
3
3-hydroxy-myristoyl-ACP synthesis (KAS16)
0
ddcaACP
-1
3
h
-2
3
malACP
-1
3
nadph
-1
3
3hmrsACP
1
3
ACP
1
3
co2
1
3
nadp
1
3
Fatty acid biosynthesis (n-C18:1) (C181SN)
0
actACP
-1
3
h
-22
3
malACP
-7
3
nadph
-15
3
ACP
7
3
co2
7
3
h2o
8
3
nadp
15
3
octeACP
1
3
Fatty acid biosynthesis (n-C14:1) (C141SN)
0
actACP
-1
3
h
-16
3
malACP
-5
3
nadph
-11
3
ACP
5
3
co2
5
3
h2o
6
3
nadp
11
3
tdeACP
1
3
b-ketoacyl synthase (KAS15)
0
accoa
-1
3
h
-1
3
malACP
-1
3
actACP
1
3
co2
1
3
coa
1
3
Acetyl-CoA ACP transacylase (ACOATA)
EC-2.3.1.38
1
ACP
-1
3
accoa
-1
3
acACP
1
3
coa
1
3
Fatty acid biosynthesis (n-C16:1) (C161SN)
0
actACP
-1
3
h
-19
3
malACP
-6
3
nadph
-13
3
ACP
6
3
co2
6
3
h2o
7
3
hdeACP
1
3
nadp
13
3
Fatty acid oxidation (n-C16:0) (FAO2)
0
atp
-1
3
coa
-8
3
fad
-7
3
h2o
-7
3
hdca
-1
3
nad
-7
3
accoa
8
3
amp
1
3
fadh2
7
3
h
7
3
nadh
7
3
ppi
1
3
Fatty acid oxidation (tetradecanoate) (FAO1)
0
atp
-1
3
coa
-7
3
fad
-6
3
h2o
-6
3
nad
-6
3
ttdca
-1
3
accoa
7
3
amp
1
3
fadh2
6
3
h
6
3
nadh
6
3
ppi
1
3
Fatty acid oxidation (octadecanoate) (FAO3)
0
atp
-1
3
coa
-9
3
fad
-8
3
h2o
-8
3
nad
-8
3
ocdca
-1
3
accoa
9
3
amp
1
3
fadh2
8
3
h
8
3
nadh
8
3
ppi
1
3
Phosphatidylglycerol phosphate phosphatase (Ecoli) (PGPP_EC)
EC-3.1.3.27
0
h2o
-1
3
pgp_EC
-0.02
3
pg_EC
0.02
3
pi
1
3
Phosphatidylglycerol synthase (Ecoli) (PGSA_EC)
EC-2.7.8.5
1
cdpdag1
-0.02
3
glyc3p
-1
3
cmp
1
3
h
1
3
pgp_EC
0.02
3
Phosphatidic acid synthase (Ecoli) (PASYN_EC)
0
glyc3p
-1
3
hdeACP
-0.14
3
myrsACP
-0.04
3
octeACP
-1
3
palmACP
-0.72
3
tdeACP
-0.1
3
ACP
2
3
pa_EC
0.02
3
Phosphatidylserine decarboxylase (Ecoli) (PSD_EC)
EC-4.1.1.65
0
h
-1
3
ps_EC
-0.02
3
co2
1
3
pe_EC
0.02
3
Phosphatidylserine syntase (Ecoli) (PSSA_EC)
EC-2.7.8.8
1
cdpdag1
-0.02
3
ser-L
-1
3
cmp
1
3
h
1
3
ps_EC
0.02
3
Methionine Metabolism
adenosylhomocysteinase (AHC)
EC-3.3.1.1
1
ahcys
-1
3
h2o
-1
3
adn
1
3
hcys-L
1
3
4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous) (DHPTDC)
0
dhptd
-1
3
h2o
1
3
hmfurn
1
3
S-ribosylhomocysteine cleavage enzyme (RHCCE)
0
rhcys
-1
3
dhptd
1
3
hcys-L
1
3
homoserine O-succinyltransferase (HSST)
EC-2.3.1.46
0
hom-L
-1
3
succoa
-1
3
coa
1
3
suchms
1
3
O-succinylhomoserine lyase (L-cysteine) (SHSL1)
EC-4.2.99.9
0
cys-L
-1
3
suchms
-1
3
cyst-L
1
3
h
1
3
succ
1
3
cystathionine b-lyase (CYSTL)
EC-4.4.1.8
0
cyst-L
-1
3
h2o
-1
3
hcys-L
1
3
nh4
1
3
pyr
1
3
methionine synthase (METS)
EC-2.1.1.13
0
5mthf
-1
3
hcys-L
-1
3
met-L
1
3
thf
1
3
methionine adenosyltransferase (METAT)
EC-2.5.1.6
0
atp
-1
3
h2o
-1
3
met-L
-1
3
amet
1
3
pi
1
3
ppi
1
3
S-adenosylhomocysteine nucleosidase (AHCYSNS)
EC-3.2.2.9
0
ahcys
-1
3
h2o
-1
3
ade
1
3
rhcys
1
3
Methylglyoxal Metabolism
lactoylglutathione lyase (LGTHL)
EC-4.4.1.5
0
gthrd
-1
3
mthgxl
-1
3
lgt-S
1
3
hydroxyacylglutathione hydrolase (GLYOX)
EC-3.1.2.6
0
h2o
-1
3
lgt-S
-1
3
gthrd
1
3
h
1
3
lac-D
1
3
methylglyoxal synthase (MGSA)
EC-4.2.3.3
0
dhap
-1
3
mthgxl
1
3
pi
1
3
Nitrogen
Ureidoglycolate hydrolase (UGLYCH)
EC-3.5.3.19
0
h
-2
3
h2o
-1
3
urdglyc
-1
3
co2
1
3
glx
1
3
nh4
2
3
allantoinase (ALLTN)
EC-3.5.2.5
0
alltn
-1
3
h2o
-1
3
alltt
1
3
h
1
3
Allantoate amidohydrolase (ALLTAH)
EC-3.5.3.4
0
alltt
-1
3
h2o
-1
3
urdglyc
1
3
urea
1
3
Cyanate aminohydrolase (CYNTAH)
0
cynt
-1
3
h
-3
3
hco3
-1
3
co2
2
3
nh4
1
3
Nucleotide Salvage Pathways
CMP nucleosidase (CMPN)
EC-3.2.2.10
0
cmp
-1
3
h2o
-1
3
csn
1
3
r5p
1
3
Adenosine deaminase (ADA)
EC-3.5.4.4
0
adn
-1
3
h
-1
3
h2o
-1
3
ins
1
3
nh4
1
3
Deoxyadenosine deaminase (DADA)
0
dad-2
-1
3
h
-1
3
h2o
-1
3
din
1
3
nh4
1
3
adenosine kinase (ADNK1)
EC-2.7.1.20
0
adn
-1
3
atp
-1
3
adp
1
3
amp
1
3
h
1
3
adenylate kinase (ADK1)
EC-2.7.4.3
1
amp
-1
3
atp
-1
3
adp
2
3
deoxyadenylate kinase (DADK)
EC-2.7.4.11
1
atp
-1
3
damp
-1
3
adp
1
3
dadp
1
3
adentylate kinase (ITP) (ADK4)
1
amp
-1
3
itp
-1
3
adp
1
3
idp
1
3
adentylate kinase (GTP) (ADK3)
1
amp
-1
3
gtp
-1
3
adp
1
3
gdp
1
3
AMP nucleosidase (AMPN)
EC-3.2.2.4
0
amp
-1
3
h2o
-1
3
ade
1
3
r5p
1
3
Ap4A hydrolase (AP4AH)
EC-3.6.1.41
0
ap4a
-1
3
h2o
-1
3
adp
2
3
h
2
3
Gp4G hydrolase (GP4GH)
0
gp4g
-1
3
h2o
-1
3
gdp
2
3
h
2
3
Ap5A hydrolase (AP5AH)
0
ap5a
-1
3
h2o
-1
3
adp
1
3
atp
1
3
h
2
3
adenine phosphoribosyltransferase (ADPT)
EC-2.4.2.7
0
ade
-1
3
prpp
-1
3
amp
1
3
ppi
1
3
cytidine deaminase (CYTD)
EC-3.5.4.5
0
cytd
-1
3
h
-1
3
h2o
-1
3
nh4
1
3
uri
1
3
deoxycytidine deaminase (DCYTD)
EC-3.5.4.14
0
dcyt
-1
3
h
-1
3
h2o
-1
3
duri
1
3
nh4
1
3
cytidylate kinase (dCMP) (CYTK2)
EC-2.7.4.14
1
atp
-1
3
dcmp
-1
3
adp
1
3
dcdp
1
3
cytidylate kinase (CMP) (CYTK1)
EC-2.7.4.14
1
atp
-1
3
cmp
-1
3
adp
1
3
cdp
1
3
UMP kinase (UMPK)
1
atp
-1
3
ump
-1
3
adp
1
3
udp
1
3
Cytosine deaminase (CSND)
EC-3.5.4.1
0
csn
-1
3
h
-1
3
h2o
-1
3
nh4
1
3
ura
1
3
adenylate cyclase (ADNCYC)
EC-4.6.1.1
0
atp
-1
3
camp
1
3
ppi
1
3
dCTP deaminase (DCTPD)
EC-3.5.4.13
0
dctp
-1
3
h
-1
3
h2o
-1
3
dutp
1
3
nh4
1
3
thymidine phosphorylase (TMDPP)
EC-2.4.2.4
1
pi
-1
3
thymd
-1
3
2dr1p
1
3
thym
1
3
deoxyuridine phosphorylase (DURIPP)
1
duri
-1
3
pi
-1
3
2dr1p
1
3
ura
1
3
Nucleoside triphosphate tripolyhydrolase (NTPTP1)
EC-3.1.5.1
0
dgtp
-1
3
h2o
-1
3
dgsn
1
3
pppi
1
3
Nucleoside triphosphate tripolyhydrolase (NTPTP2)
EC-3.1.5.1
0
gtp
-1
3
h2o
-1
3
gsn
1
3
pppi
1
3
dUTP diphosphatase (DUTPDP)
EC-3.6.1.23
0
dutp
-1
3
h2o
-1
3
dump
1
3
h
1
3
ppi
1
3
guanylate kinase (GMP:ATP) (GK1)
EC-2.7.4.8
1
atp
-1
3
gmp
-1
3
adp
1
3
gdp
1
3
deoxyguanylate kinase (dGMP:ATP) (DGK1)
EC-2.7.4.8
1
atp
-1
3
dgmp
-1
3
adp
1
3
dgdp
1
3
xanthine phosphoribosyltransferase (XPPT)
EC-2.4.2.22
0
prpp
-1
3
xan
-1
3
ppi
1
3
xmp
1
3
hypoxanthine phosphoribosyltransferase (Hypoxanthine) (HXPRT)
EC-2.4.2.8
0
hxan
-1
3
prpp
-1
3
imp
1
3
ppi
1
3
guanine phosphoribosyltransferase (GUAPRT)
0
gua
-1
3
prpp
-1
3
gmp
1
3
ppi
1
3
insosine kinase (INSK)
EC-2.7.1.73
0
atp
-1
3
ins
-1
3
adp
1
3
h
1
3
imp
1
3
guanosine kinase (GSNK)
0
atp
-1
3
gsn
-1
3
adp
1
3
gmp
1
3
h
1
3
Nucleoside triphosphate pyrophosphorylase (dctp) (NTPP3)
0
dctp
-1
3
h2o
-1
3
dcmp
1
3
h
1
3
ppi
1
3
Nucleoside triphosphate pyrophosphorylase (ctp) (NTPP4)
0
ctp
-1
3
h2o
-1
3
cmp
1
3
h
1
3
ppi
1
3
Nucleoside triphosphate pyrophosphorylase (datp) (NTPP5)
0
datp
-1
3
h2o
-1
3
damp
1
3
h
1
3
ppi
1
3
Nucleoside triphosphate pyrophosphorylase (atp) (NTPP6)
0
atp
-1
3
h2o
-1
3
amp
1
3
h
1
3
ppi
1
3
Nucleoside triphosphate pyrophosphorylase (dttp) (NTPP7)
0
dttp
-1
3
h2o
-1
3
dtmp
1
3
h
1
3
ppi
1
3
Nucleoside triphosphate pyrophosphorylase (utp) (NTPP8)
0
h2o
-1
3
utp
-1
3
h
1
3
ppi
1
3
ump
1
3
Nucleoside triphosphate pyrophosphorylase (dgtp) (NTPP1)
0
dgtp
-1
3
h2o
-1
3
dgmp
1
3
h
1
3
ppi
1
3
Nucleoside triphosphate pyrophosphorylase (gtp) (NTPP2)
0
gtp
-1
3
h2o
-1
3
gmp
1
3
h
1
3
ppi
1
3
nucleoside-diphosphate kinase (ATP:GDP) (NDPK1)
EC-2.7.4.6
1
atp
-1
3
gdp
-1
3
adp
1
3
gtp
1
3
nucleoside-diphosphate kinase (ATP:UDP) (NDPK2)
EC-2.7.4.6
1
atp
-1
3
udp
-1
3
adp
1
3
utp
1
3
nucleoside-diphosphate kinase (ATP:CDP) (NDPK3)
EC-2.7.4.6
1
atp
-1
3
cdp
-1
3
adp
1
3
ctp
1
3
nucleoside-diphosphate kinase (ATP:dGDP) (NDPK5)
EC-2.7.4.6
1
atp
-1
3
dgdp
-1
3
adp
1
3
dgtp
1
3
nucleoside-diphosphate kinase (ATP:dUDP) (NDPK6)
EC-2.7.4.6
1
atp
-1
3
dudp
-1
3
adp
1
3
dutp
1
3
nucleoside-diphosphate kinase (ATP:dCDP) (NDPK7)
EC-2.7.4.6
1
atp
-1
3
dcdp
-1
3
adp
1
3
dctp
1
3
nucleoside-diphosphate kinase (ATP:dADP) (NDPK8)
EC-2.7.4.6
1
atp
-1
3
dadp
-1
3
adp
1
3
datp
1
3
nucleoside-diphosphate kinase (ATP:dTDP) (NDPK4)
EC-2.7.4.6
1
atp
-1
3
dtdp
-1
3
adp
1
3
dttp
1
3
ribonucleoside-diphosphate reductase (ADP) (RNDR1)
EC-1.17.4.1
0
adp
-1
3
trdrd
-1
3
dadp
1
3
h2o
1
3
trdox
1
3
ribonucleoside-diphosphate reductase (GDP) (RNDR2)
EC-1.17.4.1
0
gdp
-1
3
trdrd
-1
3
dgdp
1
3
h2o
1
3
trdox
1
3
ribonucleoside-diphosphate reductase (UDP) (RNDR4)
EC-1.17.4.1
0
trdrd
-1
3
udp
-1
3
dudp
1
3
h2o
1
3
trdox
1
3
ribonucleoside-diphosphate reductase (CDP) (RNDR3)
EC-1.17.4.1
0
cdp
-1
3
trdrd
-1
3
dcdp
1
3
h2o
1
3
trdox
1
3
ribonucleoside-triphosphate reductase (ATP) (RNTR1)
EC-1.17.4.2
0
atp
-1
3
trdrd
-1
3
datp
1
3
h2o
1
3
trdox
1
3
ribonucleoside-triphosphate reductase (GTP) (RNTR2)
EC-1.17.4.2
0
gtp
-1
3
trdrd
-1
3
dgtp
1
3
h2o
1
3
trdox
1
3
ribonucleoside-triphosphate reductase (CTP) (RNTR3)
EC-1.17.4.2
0
ctp
-1
3
trdrd
-1
3
dctp
1
3
h2o
1
3
trdox
1
3
ribonucleoside-triphosphate reductase (UTP) (RNTR4)
EC-1.17.4.2
0
trdrd
-1
3
utp
-1
3
dutp
1
3
h2o
1
3
trdox
1
3
uridylate kinase (dUMP) (URIDK2r)
1
atp
-1
3
dump
-1
3
adp
1
3
dudp
1
3
deoxyuridine kinase (ATP:Deoxyuridine) (DURIK1)
0
atp
-1
3
duri
-1
3
adp
1
3
dump
1
3
h
1
3
thymidine kinase (ATP:thymidine) (TMDK1)
EC-2.7.1.21
0
atp
-1
3
thymd
-1
3
adp
1
3
dtmp
1
3
h
1
3
thymidylate synthase (TMDS)
EC-2.1.1.45
0
dump
-1
3
mlthf
-1
3
dhf
1
3
dtmp
1
3
dTMP kinase (DTMPK)
EC-2.7.4.9
1
atp
-1
3
dtmp
-1
3
adp
1
3
dtdp
1
3
uridine kinase (GTP:Uridine) (URIK2)
EC-2.7.1.48
0
gtp
-1
3
uri
-1
3
gdp
1
3
h
1
3
ump
1
3
cytidine kinase (GTP) (CYTDK2)
0
cytd
-1
3
gtp
-1
3
cmp
1
3
gdp
1
3
h
1
3
pyrimidine-nucleoside phosphorylase (uracil) (PYNP2r)
EC-2.4.2.2
1
pi
-1
3
uri
-1
3
r1p
1
3
ura
1
3
uracil phosphoribosyltransferase (UPPRT)
EC-2.4.2.9
0
prpp
-1
3
ura
-1
3
ppi
1
3
ump
1
3
5'-nucleotidase (dUMP) (NTD1)
EC-3.1.3.5
0
dump
-1
3
h2o
-1
3
duri
1
3
pi
1
3
5'-nucleotidase (dTMP) (NTD5)
EC-3.1.3.5
0
dtmp
-1
3
h2o
-1
3
pi
1
3
thymd
1
3
5'-nucleotidase (dAMP) (NTD6)
EC-3.1.3.5
0
damp
-1
3
h2o
-1
3
dad-2
1
3
pi
1
3
5'-nucleotidase (dGMP) (NTD8)
EC-3.1.3.5
0
dgmp
-1
3
h2o
-1
3
dgsn
1
3
pi
1
3
5'-nucleotidase (dCMP) (NTD3)
EC-3.1.3.5
0
dcmp
-1
3
h2o
-1
3
dcyt
1
3
pi
1
3
5'-nucleotidase (CMP) (NTD4)
EC-3.1.3.5
0
cmp
-1
3
h2o
-1
3
cytd
1
3
pi
1
3
5'-nucleotidase (AMP) (NTD7)
EC-3.1.3.5
0
amp
-1
3
h2o
-1
3
adn
1
3
pi
1
3
5'-nucleotidase (GMP) (NTD9)
EC-3.1.3.5
0
gmp
-1
3
h2o
-1
3
gsn
1
3
pi
1
3
5'-nucleotidase (IMP) (NTD11)
EC-3.1.3.5
0
h2o
-1
3
imp
-1
3
ins
1
3
pi
1
3
5'-nucleotidase (XMP) (NTD10)
EC-3.1.3.5
0
h2o
-1
3
xmp
-1
3
pi
1
3
xtsn
1
3
5'-nucleotidase (UMP) (NTD2)
EC-3.1.3.5
0
h2o
-1
3
ump
-1
3
pi
1
3
uri
1
3
purine-nucleoside phosphorylase (Deoxyinosine) (PUNP6)
EC-2.4.2.1
1
din
-1
3
pi
-1
3
2dr1p
1
3
hxan
1
3
purine-nucleoside phosphorylase (Inosine) (PUNP5)
EC-2.4.2.1
1
ins
-1
3
pi
-1
3
hxan
1
3
r1p
1
3
purine-nucleoside phosphorylase (Deoxyadenosine) (PUNP2)
EC-2.4.2.1
1
dad-2
-1
3
pi
-1
3
2dr1p
1
3
ade
1
3
purine-nucleoside phosphorylase (Deoxyguanosine) (PUNP4)
EC-2.4.2.1
1
dgsn
-1
3
pi
-1
3
2dr1p
1
3
gua
1
3
purine-nucleoside phosphorylase (Adenosine) (PUNP1)
EC-2.4.2.1
1
adn
-1
3
pi
-1
3
ade
1
3
r1p
1
3
purine-nucleoside phosphorylase (Guanosine) (PUNP3)
EC-2.4.2.1
1
gsn
-1
3
pi
-1
3
gua
1
3
r1p
1
3
purine-nucleoside phosphorylase (Xanthosine) (PUNP7)
EC-2.4.2.1
1
pi
-1
3
xtsn
-1
3
r1p
1
3
xan
1
3
guanine deaminase (GUAD)
EC-3.5.4.3
0
gua
-1
3
h
-1
3
h2o
-1
3
nh4
1
3
xan
1
3
adenine deaminase (ADD)
EC-3.5.4.2
0
ade
-1
3
h
-1
3
h2o
-1
3
hxan
1
3
nh4
1
3
Oxidative phosphorylation
L-Lactate dehydrogenase (ubiquinone) (L-LACD2)
EC-1.1.2.3
0
lac-L
-1
3
q8
-1
3
pyr
1
3
q8h2
1
3
L-Lactate dehydrogenase (menaquinone) (L-LACD3)
EC-1.1.2.3
0
lac-L
-1
3
mqn8
-1
3
mql8
1
3
pyr
1
3
ATP synthase (four protons for one ATP) (ATPS4r)
EC-3.6.3.14
1
adp
-1
3
h
-4
1
pi
-1
3
atp
1
3
h
3
3
h2o
1
3
gamma-butyrobetainyl-CoA: carnitine CoA transferase (CRNBTCT)
1
bbtcoa
-1
3
crn
-1
3
crncoa
1
3
gbbtn
1
3
crotonobetainyl-CoA: carnitine CoA transferase (CRNCBCT)
1
crn
-1
3
ctbtcoa
-1
3
crncoa
1
3
ctbt
1
3
Carnityl-CoA dehydratse (CRNCDH)
1
crncoa
-1
3
ctbtcoa
1
3
h2o
1
3
cytochrome oxidase bd (ubiquinol-8: 2 protons) (CYTBD)
0
h
-2
3
o2
-0.5
3
q8h2
-1
3
h
2
1
h2o
1
3
q8
1
3
cytochrome oxidase bo3 (ubiquinol-8: 2.5 protons) (CYTBO3)
0
h
-2.5
3
o2
-0.5
3
q8h2
-1
3
h
2.5
1
h2o
1
3
q8
1
3
D-lactate dehydrogenase (LDH_D2)
EC-1.1.2.4
0
lac-D
-1
3
q8
-1
3
pyr
1
3
q8h2
1
3
Dimethyl sulfoxide reductase (Menaquinol 8) (DMSOR1)
0
dmso
-1
3
mql8
-1
3
dms
1
3
h2o
1
3
mqn8
1
3
Dimethyl sulfoxide reductase (Demethylmenaquinol 8) (DMSOR2)
0
2dmmql8
-1
3
dmso
-1
3
2dmmq8
1
3
dms
1
3
h2o
1
3
Trimethylamine N-oxide reductase (menaquinol 8) (TMAOR1)
0
h
-1
3
mql8
-1
3
tmao
-1
3
h2o
1
3
mqn8
1
3
tma
1
3
Trimethylamine N-oxide reductase (demethylmenaquinol 8) (TMAOR2)
0
2dmmql8
-1
3
h
-1
3
tmao
-1
3
2dmmq8
1
3
h2o
1
3
tma
1
3
formate dehydrogenase (quinone-8: 2 protons) (FDH2)
EC-1.2.2.1
0
for
-1
3
h
-3
3
q8
-1
3
co2
1
3
h
2
1
q8h2
1
3
Formate Dehydrogenase (menaquinone-8: 2 protons) (FDH3)
EC-1.2.2.1
0
for
-1
3
h
-3
3
mqn8
-1
3
co2
1
3
h
2
1
mql8
1
3
Glucose dehydrogenase (ubiquinone-8 as acceptor) (GLCDe)
0
glc-D
-1
1
h2o
-1
1
q8
-1
3
glcn
1
1
h
1
1
q8h2
1
3
glycerol-3-phosphate dehydrogenase (demethylmenaquinone-8) (G3PD7)
EC-1.1.99.5
0
2dmmq8
-1
3
glyc3p
-1
3
2dmmql8
1
3
dhap
1
3
glycerol-3-phosphate dehydrogenase (menaquinone-8) (G3PD6)
EC-1.1.99.5
0
glyc3p
-1
3
mqn8
-1
3
dhap
1
3
mql8
1
3
glycerol-3-phosphate dehydrogenase (ubiquinone-8) (G3PD5)
EC-1.1.99.5
0
glyc3p
-1
3
q8
-1
3
dhap
1
3
q8h2
1
3
Hydrogenase (Demethylmenaquinone-8: 2 protons) (HYD3)
EC-1.18.99.1
0
2dmmq8
-1
3
h
-2
3
h2
-1
3
2dmmql8
1
3
h
2
1
hydrogenase (ubiquinone-8: 2 protons) (HYD1)
EC-1.18.99.1
0
h
-2
3
h2
-1
3
q8
-1
3
h
2
1
q8h2
1
3
Hydrogenase (menaquinone8: 2 protons) (HYD2)
EC-1.18.99.1
0
h
-2
3
h2
-1
3
mqn8
-1
3
h
2
1
mql8
1
3
Nitrate reductase (Ubiquinol-8) (NO3R1)
EC-1.7.99.4
0
h
-2
3
no3
-1
3
q8h2
-1
3
h
2
1
h2o
1
3
no2
1
3
q8
1
3
Nitrate reductase (Menaquinol-8) (NO3R2)
0
h
-2
3
mql8
-1
3
no3
-1
3
h
2
1
h2o
1
3
mqn8
1
3
no2
1
3
NADH dehydrogenase (ubiquinone-8 ) (NADH5)
EC-1.6.5.3
0
h
-1
3
nadh
-1
3
q8
-1
3
nad
1
3
q8h2
1
3
NADH dehydrogenase (demethylmenaquinone-8 & 0 protons) (NADH9)
EC-1.6.5.3
0
2dmmq8
-1
3
h
-1
3
nadh
-1
3
2dmmql8
1
3
nad
1
3
NADH dehydrogenase (menaquinone-8 & 0 protons) (NADH10)
EC-1.6.5.3
0
h
-1
3
mqn8
-1
3
nadh
-1
3
mql8
1
3
nad
1
3
Nitrite Reductase (NTRIR2x)
0
h
-5
3
nadh
-3
3
no2
-1
3
h2o
2
3
nad
3
3
nh4
1
3
NADH dehydrogenase (ubiquinone-8 & 3.5 protons) (NADH6)
EC-1.6.5.3
0
h
-4.5
3
nadh
-1
3
q8
-1
3
h
3.5
1
nad
1
3
q8h2
1
3
NADH dehydrogenase (menaquinone-8 & 2 protons) (NADH7)
EC-1.6.5.3
0
h
-3
3
mqn8
-1
3
nadh
-1
3
h
2
1
mql8
1
3
nad
1
3
NADH dehydrogenase (demethylmenaquinone-8 & 2.8 protons) (NADH8)
EC-1.6.5.3
0
2dmmq8
-1
3
h
-3.8
3
nadh
-1
3
2dmmql8
1
3
h
2.8
1
nad
1
3
NAD(P) transhydrogenase (THD2)
EC-1.6.1.1
0
h
-2
1
nadh
-1
3
nadp
-1
3
h
2
3
nad
1
3
nadph
1
3
pyruvate oxidase (POX)
EC-1.2.2.2
0
h2o
-1
3
pyr
-1
3
q8
-1
3
ac
1
3
co2
1
3
q8h2
1
3
succinate dehyrdogenase (SUCD4)
EC-Undetermined
1
fadh2
-1
3
q8
-1
3
fad
1
3
q8h2
1
3
NAD transhydrogenase (TEST_NADTRHD)
EC-Undetermined
0
nad
-1
3
nadph
-1
3
nadh
1
3
nadp
1
3
Trimethylamine N-oxide reductase (menaquinol 8) (TMAOR1e)
0
h
-1
1
mql8
-1
3
tmao
-1
1
h2o
1
1
mqn8
1
3
tma
1
1
Trimethylamine N-oxide reductase (demethylmenaquinol 8) (TMAOR2e)
0
2dmmql8
-1
3
h
-1
1
tmao
-1
1
2dmmq8
1
3
h2o
1
1
tma
1
1
Dimethyl sulfoxide reductase (Menaquinol 8) (DMSOR1e)
0
dmso
-1
1
mql8
-1
3
dms
1
1
h2o
1
1
mqn8
1
3
Dimethyl sulfoxide reductase (Demethylmenaquinol 8) (DMSOR2e)
0
2dmmql8
-1
3
dmso
-1
1
2dmmq8
1
3
dms
1
1
h2o
1
1
thioredoxin reductase (NADPH) (TRDR)
EC-1.6.4.5
0
h
-1
3
nadph
-1
3
trdox
-1
3
nadp
1
3
trdrd
1
3
Pentose Phosphate Cycle
6-phosphogluconolactonase (PGL)
EC-3.1.1.31
0
6pgl
-1
3
h2o
-1
3
6pgc
1
3
h
1
3
2-dehydro-3-deoxy-phosphogluconate aldolase (EDA)
EC-4.1.2.14
0
2ddg6p
-1
3
g3p
1
3
pyr
1
3
6-phosphogluconate dehydratase (EDD)
0
6pgc
-1
3
2ddg6p
1
3
h2o
1
3
phosphogluconate dehydrogenase (GND)
EC-1.1.1.44
0
6pgc
-1
3
nadp
-1
3
co2
1
3
nadph
1
3
ru5p-D
1
3
ribulose 5-phosphate 3-epimerase (RPE)
EC-5.1.3.1
1
ru5p-D
-1
3
xu5p-D
1
3
ribose-5-phosphate isomerase (RPI)
EC-5.3.1.6
1
r5p
-1
3
ru5p-D
1
3
transaldolase (TALA)
EC-2.2.1.2
1
g3p
-1
3
s7p
-1
3
e4p
1
3
f6p
1
3
transketolase (TKT1)
EC-2.2.1.1
1
r5p
-1
3
xu5p-D
-1
3
g3p
1
3
s7p
1
3
transketolase (TKT2)
EC-2.2.1.1
1
e4p
-1
3
xu5p-D
-1
3
f6p
1
3
g3p
1
3
glucose 6-phosphate dehydrogenase (G6PDH2r)
EC-1.1.1.49
1
g6p
-1
3
nadp
-1
3
6pgl
1
3
h
1
3
nadph
1
3
Purine and Pyrimidine Biosynthesis
GMP synthase (GMPS2)
EC-6.3.5.2
0
atp
-1
3
gln-L
-1
3
h2o
-1
3
xmp
-1
3
amp
1
3
glu-L
1
3
gmp
1
3
h
2
3
ppi
1
3
IMP dehydrogenase (IMPD)
EC-1.1.1.205
0
h2o
-1
3
imp
-1
3
nad
-1
3
h
1
3
nadh
1
3
xmp
1
3
GMP reductase (GMPR)
EC-1.6.6.8
0
gmp
-1
3
h
-2
3
nadph
-1
3
imp
1
3
nadp
1
3
nh4
1
3
adenylosuccinate synthase (ADSS)
EC-6.3.4.4
0
asp-L
-1
3
gtp
-1
3
imp
-1
3
dcamp
1
3
gdp
1
3
h
2
3
pi
1
3
adenylosuccinate lyase (ADSL2r)
EC-4.3.2.2
1
25aics
-1
3
aicar
1
3
fum
1
3
adenylsuccinate lyase (ADSL1r)
EC-4.3.2.2
1
dcamp
-1
3
amp
1
3
fum
1
3
phosphoribosylaminoimidazolesuccinocarboxamide synthase (PRASCS)
EC-6.3.2.6
1
5aizc
-1
3
asp-L
-1
3
atp
-1
3
25aics
1
3
adp
1
3
h
1
3
pi
1
3
phosphoribosylglycinamide synthase (PRAGSr)
EC-6.3.4.13
1
atp
-1
3
gly
-1
3
pram
-1
3
adp
1
3
gar
1
3
h
1
3
pi
1
3
phosphoribosylaminoimidazole carboxylase (mutase rxn) (AIRC3)
1
5aizc
-1
3
5caiz
1
3
glutamine phosphoribosyldiphosphate amidotransferase (GLUPRT)
EC-2.4.2.14
0
gln-L
-1
3
h2o
-1
3
prpp
-1
3
glu-L
1
3
ppi
1
3
pram
1
3
phosphoribosylaminoimidazolecarboxamide formyltransferase (AICART)
EC-2.1.2.3
1
10fthf
-1
3
aicar
-1
3
fprica
1
3
thf
1
3
IMP cyclohydrolase (IMPC)
EC-3.5.4.10
1
h2o
-1
3
imp
-1
3
fprica
1
3
phosphoribosylaminoimidazole carboxylase (AIRC2)
0
air
-1
3
atp
-1
3
hco3
-1
3
5caiz
1
3
adp
1
3
h
1
3
pi
1
3
phosphoribosylformylglycinamidine synthase (PRFGS)
EC-6.3.5.3
0
atp
-1
3
fgam
-1
3
gln-L
-1
3
h2o
-1
3
adp
1
3
fpram
1
3
glu-L
1
3
h
1
3
pi
1
3
phosphoribosylaminoimidazole synthase (PRAIS)
EC-6.3.3.1
0
atp
-1
3
fpram
-1
3
adp
1
3
air
1
3
h
2
3
pi
1
3
phosphoribosylglycinamide formyltransferase (GARFT)
EC-2.1.2.2
1
10fthf
-1
3
gar
-1
3
fgam
1
3
h
1
3
thf
1
3
GAR transformylase-T (GART)
0
atp
-1
3
for
-1
3
gar
-1
3
adp
1
3
fgam
1
3
h
1
3
pi
1
3
aspartate carbamoyltransferase (ASPCT)
EC-2.1.3.2
0
asp-L
-1
3
cbp
-1
3
cbasp
1
3
h
1
3
pi
1
3
dihydroorotase (DHORTS)
EC-3.5.2.3
1
dhor-S
-1
3
h2o
-1
3
cbasp
1
3
h
1
3
dihydoorotic acid dehydrogenase (quinone8) (DHORD2)
EC-1.3.3.1
0
dhor-S
-1
3
q8
-1
3
orot
1
3
q8h2
1
3
dihydroorotic acid (menaquinone-8) (DHORD5)
EC-1.3.3.1
0
dhor-S
-1
3
mqn8
-1
3
mql8
1
3
orot
1
3
orotate phosphoribosyltransferase (ORPT)
EC-2.4.2.10
1
orot5p
-1
3
ppi
-1
3
orot
1
3
prpp
1
3
orotidine-5'-phosphate decarboxylase (OMPDC)
EC-4.1.1.23
0
h
-1
3
orot5p
-1
3
co2
1
3
ump
1
3
CTP synthase (glutamine) (CTPS2)
EC-6.3.4.2
0
atp
-1
3
gln-L
-1
3
h2o
-1
3
utp
-1
3
adp
1
3
ctp
1
3
glu-L
1
3
h
2
3
pi
1
3
Putative
Carbamate kinase (CBMK)
EC-2.7.2.2
0
atp
-1
3
co2
-1
3
nh4
-1
3
adp
1
3
cbp
1
3
h
2
3
N-acetylmannosamine 6-phoshpate epimerase (AMANAPE)
0
acmanap
-1
3
acgam6p
1
3
N-acetyl-D-mannosamine kinase (AMANK)
EC-2.7.1.60
0
acmana
-1
3
atp
-1
3
acmanap
1
3
adp
1
3
h
1
3
Putative Transporters
allantoin transport in via proton symport (ALLTNt2r)
1
alltn
-1
1
h
-1
1
alltn
1
3
h
1
3
arginine/ornithine antiporter (ARGORNt7)
1
arg-L
-1
1
orn
-1
3
arg-L
1
3
orn
1
1
acetoacetate transport via proton symport (ACACt2)
1
acac
-1
1
h
-1
1
acac
1
3
h
1
3
Butyrate transport via proton symport, reversible (BUTt2r)
1
but
-1
1
h
-1
1
but
1
3
h
1
3
Cyanate transport via proton symport (CYNTt2)
0
cynt
-1
1
h
-1
1
cynt
1
3
h
1
3
D-galactarte transport via proton symport, reversible (GALCTt2r)
1
galct-D
-1
1
h
-1
1
galct-D
1
3
h
1
3
D-glucarate transport via proton symport, reversible (GLCRt2r)
1
glcr
-1
1
h
-1
1
glcr
1
3
h
1
3
3-phenylpropionate transport via proton symport, reversible (PPPNt2r)
1
h
-1
1
pppn
-1
1
h
1
3
pppn
1
3
3-(3-hydroxyphenyl)propionate transport via proton symport, reversible (HPPPNt2r)
1
3hpppn
-1
1
h
-1
1
3hpppn
1
3
h
1
3
3-hydroxycinnamic acid transport via proton symport, reversible (HCINNMt2r)
1
3hcinnm
-1
1
h
-1
1
3hcinnm
1
3
h
1
3
4-aminobutyrate/glutamate antiport (GLUABUTt7)
1
4abut
-1
3
glu-L
-1
1
4abut
1
1
glu-L
1
3
L-alanine reversible transport via proton symport (ALAt2r)
1
ala-L
-1
1
h
-1
1
ala-L
1
3
h
1
3
uracil transport in via proton symport, reversible (URAt2r)
1
h
-1
1
ura
-1
1
h
1
3
ura
1
3
Glycine betaine transport via proton symport, reversible (GLYBt2r)
1
glyb
-1
1
h
-1
1
glyb
1
3
h
1
3
choline transport via ABC system (CHLabc)
0
atp
-1
3
chol
-1
1
h2o
-1
3
adp
1
3
chol
1
3
h
1
3
pi
1
3
Glycine betaine transport via ABC system (GLYBabc)
0
atp
-1
3
glyb
-1
1
h2o
-1
3
adp
1
3
glyb
1
3
h
1
3
pi
1
3
Tartrate/succinate antiporter (TARTRt7)
1
succ
-1
3
tartr-L
-1
1
succ
1
1
tartr-L
1
3
Succinate transport via ABC system (SUCCabc)
0
atp
-1
3
h2o
-1
3
succ
-1
1
adp
1
3
h
1
3
pi
1
3
succ
1
3
guanine transport in via proton symport (GUAt2)
0
gua
-1
1
h
-1
1
gua
1
3
h
1
3
xanthine transport in via proton symport (XANt2)
0
h
-1
1
xan
-1
1
h
1
3
xan
1
3
Pyruvate metabolism
acetate kinase (ACKr)
EC-2.7.2.1
1
ac
-1
3
atp
-1
3
actp
1
3
adp
1
3
acetyl-CoA synthetase (ACS)
EC-6.2.1.1
0
ac
-1
3
atp
-1
3
coa
-1
3
accoa
1
3
amp
1
3
ppi
1
3
Acetaldehyde dehydrogenase (ADHEr)
EC-Undetermined
1
accoa
-1
3
h
-2
3
nadh
-2
3
coa
1
3
etoh
1
3
nad
2
3
D-lactate dehydrogenase (LDH_D)
EC-1.1.1.28
1
lac-D
-1
3
nad
-1
3
h
1
3
nadh
1
3
pyr
1
3
Formate-hydrogen lyase (FHL)
0
for
-1
3
h
-1
3
co2
1
3
h2
1
3
phosphotransacetylase (PTAr)
EC-2.3.1.8
1
accoa
-1
3
pi
-1
3
actp
1
3
coa
1
3
pyruvate formate lyase (PFL)
EC-Undetermined
0
coa
-1
3
pyr
-1
3
accoa
1
3
for
1
3
Threonine and Lysine Metabolism
succinyldiaminopimelate transaminase (SDPTA)
EC-2.6.1.17
1
akg
-1
3
sl26da
-1
3
glu-L
1
3
sl2a6o
1
3
aspartate-semialdehyde dehydrogenase (ASAD)
EC-1.2.1.11
1
aspsa
-1
3
nadp
-1
3
pi
-1
3
4pasp
1
3
h
1
3
nadph
1
3
dihydrodipicolinate synthase (DHDPS)
EC-4.2.1.52
0
aspsa
-1
3
pyr
-1
3
23dhdp
1
3
h
1
3
h2o
2
3
dihydrodipicolinate reductase (NADPH) (DHDPRy)
EC-1.3.1.26
0
23dhdp
-1
3
h
-1
3
nadph
-1
3
nadp
‰ >sbo)ch>1<'ztoicl=
$,kmpoqFd>:™ =contou>d>
<Îame6tèdp,/hame>
™
tetrahydropicolinate succinylase (THDPS)
EC-2.3.1.117
0
h2o
-1
3
succoa
-1
3
=namõþth%r-1.cwoi#h>
0/ckmpouîq>
>cmmpnand>:
@oaame:
1ƒtoichŽ
<7catooj>3J
)Š 1<-spoich> 8¼o#at)on>6/lmcitig~>
<ïsdect©on>©
|name6suëoi.yl=dùahinopim%lavg"desucól+yl`se (SLPDS%J EC-35.1.38
)™0
h2o,/feme> -1<¿sdïich>
<,ocatioj>3s|26dm/ni}e>
-1<-süoich>
i 1
quc#|/nQme>
1
3
diaminopimelate epimerase (DAPE)
EC-5.1.1.7
1
26dap-LL
-1
3
26dap-M
1
3
lysine decarboxylase (LYSDC)
EC-4.1.1.18
0
h
-1
3
lys-L
-1
3
15dap
1
3
co2
1
3
Threonine Aldolase (THRAr)
EC-4.1.2.5
1
thr-L
-1
3
acald
1
3
gly
1
3
diaminopimelate decarboxylase (DAPDC)
EC-4.1.1.20
0
26dap-M
-1
3
h
-1
3
co2
1
3
lys-L
1
3
homoserine dehydrogenase (NADPH) (HSDy)
EC-1.1.1.3
1
hom-L
-1
3
nadp
-1
3
aspsa
1
3
h
1
3
nadph
1
3
aspartate kinase (ASPK)
EC-2.7.2.4
1
asp-L
-1
3
atp
-1
3
4pasp
1
3
adp
1
3
homoserine kinase (HSK)
EC-2.7.1.39
0
atp
-1
3
hom-L
-1
3
adp
1
3
h
1
3
phom
1
3
threonine synthase (THRS)
EC-4.2.3.1
0
h2o
-1
3
phom
-1
3
pi
1
3
thr-L
1
3
Transport, Extracellular
S-Propane-1,2-diol facilitated transport (12PPDt)
1
12ppd-S
-1
1
12ppd-S
1
3
NMN transport via NMN glycohydrolase (NMNt7)
EC-3.2.2.14
0
h2o
-1
3
nmn
-1
1
h
1
3
ncam
1
3
r5p
1
3
acetaldehyde reversible transport (ACALDt)
1
acald
-1
1
acald
1
3
Guanine transport (GUAt)
1
gua
-1
1
gua
1
3
Hypoxanthine transport (HYXNt)
1
hxan
-1
1
hxan
1
3
xanthine reversible transport (XANt)
1
xan
-1
1
xan
1
3
Nicotinic acid uptake (NACUP)
0
nac
-1
1
nac
1
3
L-asparagine transport via ABC system (ASNabc)
0
asn-L
-1
1
atp
-1
3
h2o
-1
3
adp
1
3
asn-L
1
3
h
1
3
pi
1
3
L-asparagine reversible transport via proton symport (ASNt2r)
1
asn-L
-1
1
h
-1
1
asn-L
1
3
h
1
3
M-diaminopimelic acid ABC transport (DAPabc)
0
26dap-M
-1
1
atp
-1
3
h2o
-1
3
26dap-M
1
3
adp
1
3
h
1
3
pi
1
3
L-cysteine transport via ABC system (CYSabc)
0
atp
-1
3
cys-L
-1
1
h2o
-1
3
adp
1
3
cys-L
1
3
h
1
3
pi
1
3
acetate reversible transport via proton symport (ACt2r)
1
ac
-1
1
h
-1
1
ac
1
3
h
1
3
ethanol reversible transport via proton symport (ETOHt2r)
1
etoh
-1
1
h
-1
1
etoh
1
3
h
1
3
pyruvate reversible transport via proton symport (PYRt2r)
1
h
-1
1
pyr
-1
1
h
1
3
pyr
1
3
o2 transport (diffusion) (O2t)
1
o2
-1
1
o2
1
3
CO2 transporter via diffusion (CO2t)
1
co2
-1
1
co2
1
3
H2O transport via diffusion (H2Ot)
1
h2o
-1
1
h2o
1
3
Dihydroxyacetone transport via facilitated diffusion (DHAt)
1
dha
-1
1
dha
1
3
ammonia reversible transport (NH3t)
1
nh4
-1
1
nh4
1
3
L-arabinose transport via proton symport (ARBt2r)
1
arab-L
-1
1
h
-1
1
arab-L
1
3
h
1
3
L-arabinose transport via ABC system (ARBabc)
0
arab-L
-1
1
atp
-1
3
h2o
-1
3
adp
1
3
arab-L
1
3
h
1
3
pi
1
3
L-histidine reversible transport via proton symport (HISt2r)
1
h
-1
1
his-L
-1
1
h
1
3
his-L
1
3
L-phenylalanine reversible transport via proton symport (PHEt2r)
1
h
-1
1
phe-L
-1
1
h
1
3
phe-L
1
3
L-leucine reversible transport via proton symport (LEUt2r)
1
h
-1
1
leu-L
-1
1
h
1
3
leu-L
1
3
L-valine reversible transport via proton symport (VALt2r)
1
h
-1
1
val-L
-1
1
h
1
3
val-L
1
3
L-isoleucine reversible transport via proton symport (ILEt2r)
1
h
-1
1
ile-L
-1
1
h
1
3
ile-L
1
3
Cob(1)alamin transport via ABC system (CBL1abc)
0
atp
-1
3
cbl1
-1
1
h2o
-1
3
adp
1
3
cbl1
1
3
h
1
3
pi
1
3
Lysine/Cadaverine antiporter (CADVt)
0
15dap
-1
3
h
-1
1
lys-L
-1
1
15dap
1
1
h
1
3
lys-L
1
3
Carnitine/butyrobetaine antiporter (CRNt7)
0
crn
-1
1
gbbtn
-1
3
crn
1
3
gbbtn
1
1
sodium proton antiporter (H:NA is 1:1) (NAt3_1)
1
h
-1
1
na1
-1
3
h
1
3
na1
1
1
Citrate transport via succinate antiport (CITt7)
0
cit
-1
1
succ
-1
3
cit
1
3
succ
1
1
cytosine transport in via proton symport (CSNt2)
0
csn
-1
1
h
-1
1
csn
1
3
h
1
3
maltose transport via PEP:Pyr PTS (MALTpts)
0
malt
-1
1
pep
-1
3
malt6p
1
3
pyr
1
3
N-Acetyl-D-glucosamine transport via PEP:Pyr PTS (ACGApts)
0
acgam
-1
1
pep
-1
3
acgam6p
1
3
pyr
1
3
D-alanine transport via proton symport (DALAt2r)
1
ala-D
-1
1
h
-1
1
ala-D
1
3
h
1
3
D-serine transport via proton symport (DSERt2r)
1
h
-1
1
ser-D
-1
1
h
1
3
ser-D
1
3
glycine reversible transport via proton symport (GLYt2r)
1
gly
-1
1
h
-1
1
gly
1
3
h
1
3
sulfate transport via ABC system (SULabc)
0
atp
-1
3
h2o
-1
3
so4
-1
1
adp
1
3
h
1
3
pi
1
3
so4
1
3
Aspartate transport via proton symport (2 H) (ASPt2_2)
0
asp-L
-1
1
h
-2
1
asp-L
1
3
h
2
3
Fumarate transport via proton symport (2 H) (FUMt2_2)
0
fum
-1
1
h
-2
1
fum
1
3
h
2
3
Malate transport via proton symport (2 H) (MALt2_2)
0
h
-2
1
mal-L
-1
1
h
2
3
mal-L
1
3
succinate transport via proton symport (2 H) (SUCCt2_2)
0
h
-2
1
succ
-1
1
h
2
3
succ
1
3
L-asparate transport via proton symport (3 H) (ASPt2_3)
0
asp-L
-1
1
h
-3
1
asp-L
1
3
h
3
3
Malate transport via proton symport (3 H) (MALt2_3)
0
h
-3
1
mal-L
-1
1
h
3
3
mal-L
1
3
Succintate transport via proton symport (3 H) (SUCCt2_3)
0
h
-3
1
succ
-1
1
h
3
3
succ
1
3
Succinate efflux via proton symport (SUCCt2b)
0
h
-1
3
succ
-1
3
h
1
1
succ
1
1
Fumarate transport via proton symport (3 H) (FUMt2_3)
0
fum
-1
1
h
-3
1
fum
1
3
h
3
3
succinate:fumarate antiporter (SUCFUMt)
1
fum
-1
1
succ
-1
3
fum
1
3
succ
1
1
D-galactonate transport via proton symport, reversible (GALCTNt2r)
1
galctn-D
-1
1
h
-1
1
galctn-D
1
3
h
1
3
D-galacturonate transport via proton symport, reversible (GALURt2r)
1
galur
-1
1
h
-1
1
galur
1
3
h
1
3
D-glucuronate transport via proton symport, reversible (GLCURt2r)
1
glcur
-1
1
h
-1
1
glcur
1
3
h
1
3
Octadecanoate transport via proton symport (OCDCAt2)
0
h
-1
1
ocdca
-1
1
h
1
3
ocdca
1
3
Hexadecanoate transport via proton symport (HDCAt2)
0
h
-1
1
hdca
-1
1
h
1
3
hdca
1
3
Tetradecanoate transport via proton symport (TTDCAt2)
0
h
-1
1
ttdca
-1
1
h
1
3
ttdca
1
3
iron (II) transport via ABC system (FE2abc)
0
atp
-1
3
fe2
-1
1
h2o
-1
3
adp
1
3
fe2
1
3
h
1
3
pi
1
3
formate transport via diffusion (FORt)
1
for
-1
1
for
1
3
L-fucose transport via proton symport (FUCt)
1
fuc-L
-1
1
h
-1
1
fuc-L
1
3
h
1
3
4-aminobutyrate transport in via proton symport (ABUTt2)
0
4abut
-1
1
h
-1
1
4abut
1
3
h
1
3
D-galactose transport in via proton symport (GALt2)
0
gal
-1
1
h
-1
1
gal
1
3
h
1
3
D-glucose transport in via proton symport (GLCt2)
0
glc-D
-1
1
h
-1
1
glc-D
1
3
h
1
3
Galactitol transport via PEP:Pyr PTS (GALTpts)
0
galt
-1
1
pep
-1
3
galt1p
1
3
pyr
1
3
L-glutamine transport via ABC system (GLNabc)
0
atp
-1
3
gln-L
-1
1
h2o
-1
3
adp
1
3
gln-L
1
3
h
1
3
pi
1
3
glycerol transport via channel (GLYCt)
1
glyc
-1
3
glyc
1
1
Glyceraldehyde facilitated diffusion (GLYALDt)
1
glyald
-1
1
glyald
1
3
Urea transport via facilitate diffusion (UREAt)
1
urea
-1
1
urea
1
3
Glycerol-3-phosphate : phosphate antiporter (GLYC3Pt6)
0
glyc3p
-1
1
pi
-1
3
glyc3p
1
3
pi
1
1
L-aspartate transport via ABC system (ASPabc)
0
asp-L
-1
1
atp
-1
3
h2o
-1
3
adp
1
3
asp-L
1
3
h
1
3
pi
1
3
L-glutamate transport via ABC system (GLUabc)
0
atp
-1
3
glu-L
-1
1
h2o
-1
3
adp
1
3
glu-L
1
3
h
1
3
pi
1
3
L-aspartate transport in via proton symport (ASPt2)
0
asp-L
-1
1
h
-1
1
asp-L
1
3
h
1
3
L-glutamate transport via proton symport, reversible (GLUt2r)
1
glu-L
-1
1
h
-1
1
glu-L
1
3
h
1
3
Na+/glutamate symport (GLUt4)
0
glu-L
-1
1
na1
-1
1
glu-L
1
3
na1
1
3
ornithine transport via ABC system (ORNabc)
0
atp
-1
3
h2o
-1
3
orn
-1
1
adp
1
3
h
1
3
orn
1
3
pi
1
3
L-arginine transport via ABC system (ARGabc)
0
arg-L
-1
1
atp
-1
3
h2o
-1
3
adp
1
3
arg-L
1
3
h
1
3
pi
1
3
L-histidine transport via ABC system (HISabc)
0
atp
-1
3
h2o
-1
3
his-L
-1
1
adp
1
3
h
1
3
his-L
1
3
pi
1
3
L-lysine transport via ABC system (LYSabc)
0
atp
-1
3
h2o
-1
3
lys-L
-1
1
adp
1
3
h
1
3
lys-L
1
3
pi
1
3
L-idonate transport via proton symport, reversible (IDONt2r)
1
h
-1
1
idon-L
-1
1
h
1
3
idon-L
1
3
D-gluconate transport via proton symport, reversible (GLCNt2r)
1
glcn
-1
1
h
-1
1
glcn
1
3
h
1
3
2-dehydro-3-deoxy-D-gluconate transport via proton symport, reversible (DDGLCNt2r)
1
2ddglcn
-1
1
h
-1
1
2ddglcn
1
3
h
1
3
Potassium ABC transporter (Kabc)
0
atp
-1
3
h2o
-1
3
k
-1
1
adp
1
3
h
1
3
k
1
3
pi
1
3
2-oxoglutarate reversible transport via symport (AKGt2r)
1
akg
-1
1
h
-1
1
akg
1
3
h
1
3
Lactose transport via proton symport (LCTSt)
1
h
-1
1
lcts
-1
1
h
1
3
lcts
1
3
L-isoleucine transport via ABC system (ILEabc)
0
atp
-1
3
h2o
-1
3
ile-L
-1
1
adp
1
3
h
1
3
ile-L
1
3
pi
1
3
L-threonine transport via ABC system (THRabc)
0
atp
-1
3
h2o
-1
3
thr-L
-1
1
adp
1
3
h
1
3
pi
1
3
thr-L
1
3
L-alanine transport via ABC system (ALAabc)
0
ala-L
-1
1
atp
-1
3
h2o
-1
3
adp
1
3
ala-L
1
3
h
1
3
pi
1
3
L-valine transport via ABC system (VALabc)
0
atp
-1
3
h2o
-1
3
val-L
-1
1
adp
1
3
h
1
3
pi
1
3
val-L
1
3
L-leucine transport via ABC system (LEUabc)
0
atp
-1
3
h2o
-1
3
leu-L
-1
1
adp
1
3
h
1
3
leu-L
1
3
pi
1
3
D-lactate transport via proton symport (D-LACt2)
1
h
-1
1
lac-D
-1
1
h
1
3
lac-D
1
3
glycolate transport via proton symport, reversible (GLYCLTt2r)
1
glyclt
-1
1
h
-1
1
glyclt
1
3
h
1
3
L-lactate reversible transport via proton symport (L-LACt2r)
1
h
-1
1
lac-L
-1
1
h
1
3
lac-L
1
3
L-lysine reversible transport via proton symport (LYSt2r)
1
h
-1
1
lys-L
-1
1
h
1
3
lys-L
1
3
maltopentaose transport via ABC system (MALTPTabc)
0
atp
-1
3
h2o
-1
3
maltpt
-1
1
adp
1
3
h
1
3
maltpt
1
3
pi
1
3
maltose transport via ABC system (MALTabc)
0
atp
-1
3
h2o
-1
3
malt
-1
1
adp
1
3
h
1
3
malt
1
3
pi
1
3
maltotetraose transport via ABC system (MALTTTRabc)
0
atp
-1
3
h2o
-1
3
maltttr
-1
1
adp
1
3
h
1
3
maltttr
1
3
pi
1
3
maltohexaose transport via ABC system (MALTHXabc)
0
atp
-1
3
h2o
-1
3
malthx
-1
1
adp
1
3
h
1
3
malthx
1
3
pi
1
3
Maltotriose transport via ABC system (MALTTRabc)
0
atp
-1
3
h2o
-1
3
malttr
-1
1
adp
1
3
h
1
3
malttr
1
3
pi
1
3
Fructose transport via PEP:Pyr PTS (f6p generating) (FRUpts2)
0
fru
-1
1
pep
-1
3
f6p
1
3
pyr
1
3
D-mannose transport via PEP:Pyr PTS (MANpts)
0
man
-1
1
pep
-1
3
man6p
1
3
pyr
1
3
D-glucosamine transport via PEP:Pyr PTS (GAMpts)
0
gam
-1
1
pep
-1
3
gam6p
1
3
pyr
1
3
melibiose transport in via symport (MELIBt2)
0
h
-1
1
melib
-1
1
h
1
3
melib
1
3
L-methionine transport via ABC system (METabc)
0
atp
-1
3
h2o
-1
3
met-L
-1
1
adp
1
3
h
1
3
met-L
1
3
pi
1
3
D-methionine transport via ABC system (METDabc)
0
atp
-1
3
h2o
-1
3
met-D
-1
1
adp
1
3
h
1
3
met-D
1
3
pi
1
3
D-galactose transport via ABC system (GALabc)
0
atp
-1
3
gal
-1
1
h2o
-1
3
adp
1
3
gal
1
3
h
1
3
pi
1
3
Indole transport via proton symport, reversible (INDOLEt2r)
1
h
-1
1
indole
-1
1
h
1
3
indole
1
3
N-acetylneuraminate proton symport (ACNAMt2)
0
acnam
-1
1
h
-1
1
acnam
1
3
h
1
3
nitrate transport in via nitrite antiport (NO3t7)
0
no2
-1
3
no3
-1
1
no2
1
1
no3
1
3
nitrite transport in via proton symport, reversible (NO2t2r)
1
h
-1
1
no2
-1
1
h
1
3
no2
1
3
sodium proton antiporter (H:NA is 2) (NAt3_2)
0
h
-2
1
na1
-1
3
h
2
3
na1
1
1
sodium proton antiporter (H:NA is 1.5) (NAt3_1.5)
0
h
-3
1
na1
-2
3
h
3
3
na1
2
1
guanosine transport in via proton symport (GSNt2)
0
gsn
-1
1
h
-1
1
gsn
1
3
h
1
3
deoxyguanosine transport in via proton symport (DGSNt2)
0
dgsn
-1
1
h
-1
1
dgsn
1
3
h
1
3
inosine transport in via proton symport (INSt2)
0
h
-1
1
ins
-1
1
h
1
3
ins
1
3
deoxyinosine transport in via proton symport (DINSt2)
0
din
-1
1
h
-1
1
din
1
3
h
1
3
adenosine transport in via proton symport (ADNt2)
0
adn
-1
1
h
-1
1
adn
1
3
h
1
3
uridine transport in via proton symport (URIt2)
0
h
-1
1
uri
-1
1
h
1
3
uri
1
3
cytidine transport in via proton symport (CYTDt2)
0
cytd
-1
1
h
-1
1
cytd
1
3
h
1
3
deoxycytidine transport in via proton symport (DCYTt2)
0
dcyt
-1
1
h
-1
1
dcyt
1
3
h
1
3
deoxyuridine transport in via proton symport (DURIt2)
0
duri
-1
1
h
-1
1
duri
1
3
h
1
3
deoxyadenosine transport in via proton symport (DADNt2)
0
dad-2
-1
1
h
-1
1
dad-2
1
3
h
1
3
thymidine transport in via proton symport (THMDt2)
0
h
-1
1
thymd
-1
1
h
1
3
thymd
1
3
Pantothenate sodium symporter (PNTOt4)
0
na1
-1
1
pnto-R
-1
1
na1
1
3
pnto-R
1
3
phosphate reversible transport via symport (PIt2r)
1
h
-1
1
pi
-1
1
h
1
3
pi
1
3
NMN permease (NMNP)
0
nmn
-1
1
nmn
1
3
putrescine transport via ABC system (PTRCabc)
0
atp
-1
3
h2o
-1
3
ptrc
-1
1
adp
1
3
h
1
3
pi
1
3
ptrc
1
3
spermidine transport via ABC system (SPMDabc)
0
atp
-1
3
h2o
-1
3
spmd
-1
1
adp
1
3
h
1
3
pi
1
3
spmd
1
3
putrescine/ornithine antiporter (PTRCORNt7)
1
orn
-1
3
ptrc
-1
1
orn
1
1
ptrc
1
3
putrescine transport in via proton symport, reversible (PTRCt2r)
1
h
-1
1
ptrc
-1
1
h
1
3
ptrc
1
3
L-proline reversible transport via proton symport (PROt2r)
1
h
-1
1
pro-L
-1
1
h
1
3
pro-L
1
3
L-proline transport via ABC system (PROabc)
0
atp
-1
3
h2o
-1
3
pro-L
-1
1
adp
1
3
h
1
3
pi
1
3
pro-L
1
3
phosphate transport via ABC system (PIabc)
0
atp
-1
3
h2o
-1
3
pi
-1
1
adp
1
3
h
1
3
pi
2
3
N-acetyl-D-mannosamine transport via PTS (ACMANApts)
0
acmana
-1
1
pep
-1
3
acmanap
1
3
pyr
1
3
mannitol transport via PEP:Pyr PTS (MNLpts)
0
mnl
-1
1
pep
-1
3
mnl1p
1
3
pyr
1
3
sucrose transport via PEP:Pyr PTS (SUCpts)
0
pep
-1
3
sucr
-1
1
pyr
1
3
suc6p
1
3
D-glucose transport via PEP:Pyr PTS (GLCpts)
0
glc-D
-1
1
pep
-1
3
g6p
1
3
pyr
1
3
D-fructose transport via PEP:Pyr PTS (FRUpts)
0
fru
-1
1
pep
-1
3
f1p
1
3
pyr
1
3
trehalose transport via PEP:Pyr PTS (TREpts)
0
pep
-1
3
tre
-1
1
pyr
1
3
tre6p
1
3
Na+/Proline-L symporter (PROt4)
0
na1
-1
1
pro-L
-1
1
na1
1
3
pro-L
1
3
L-rhamnose transport via proton symport (RMNt)
0
h
-1
1
rmn
-1
1
h
1
3
rmn
1
3
thiosulfate transport via ABC system (TSULabc)
0
atp
-1
3
h2o
-1
3
tsul
-1
1
adp
1
3
h
1
3
pi
1
3
tsul
1
3
L-serine reversible transport via proton symport (SERt2r)
1
h
-1
1
ser-L
-1
1
h
1
3
ser-L
1
3
thiamine transport via ABC system (THMabc)
0
atp
-1
3
h2o
-1
3
thm
-1
1
adp
1
3
h
1
3
pi
1
3
thm
1
3
D-sorbitol transport via PEP:Pyr PTS (SBTpts)
0
pep
-1
3
sbt-D
-1
1
pyr
1
3
sbt6p
1
3
L-serine via sodium symport (SERt4)
0
na1
-1
1
ser-L
-1
1
na1
1
3
ser-L
1
3
L-threonine via sodium symport (THRt4)
0
na1
-1
1
thr-L
-1
1
na1
1
3
thr-L
1
3
taurine transport via ABC system (TAURabc)
0
atp
-1
3
h2o
-1
3
taur
-1
1
adp
1
3
h
1
3
pi
1
3
taur
1
3
L-threonine reversible transport via proton symport (THRt2r)
1
h
-1
1
thr-L
-1
1
h
1
3
thr-L
1
3
L-tryptophan reversible transport via proton symport (TRPt2r)
1
h
-1
1
trp-L
-1
1
h
1
3
trp-L
1
3
potassium reversible transport via proton symport (Kt2r)
1
h
-1
1
k
-1
1
h
1
3
k
1
3
L-tyrosine reversible transport via proton symport (TYRt2r)
1
h
-1
1
tyr-L
-1
1
h
1
3
tyr-L
1
3
sn-Glycerol 3-phosphate transport via ABC system (GLYC3Pabc)
0
atp
-1
3
glyc3p
-1
1
h2o
-1
3
adp
1
3
glyc3p
1
3
h
1
3
pi
1
3
Mannose-6-phosphate transport via phosphate antiport (MAN6Pt6_2)
0
man6p
-1
1
pi
-2
3
man6p
1
3
pi
2
1
Glucose-6-phosphate transport via phosphate antiport (G6Pt6_2)
0
g6p
-1
1
pi
-2
3
g6p
1
3
pi
2
1
Fucose 1-phosphate transport via phosphate antiport (FUCPt6_2)
0
fuc1p-L
-1
1
pi
-2
3
fuc1p-L
1
3
pi
2
1
uracil transport in via proton symport (URAt2)
0
h
-1
1
ura
-1
1
h
1
3
ura
1
3
Xanthosine transport via proton symport (XTSNt2r)
1
h
-1
1
xtsn
-1
1
h
1
3
xtsn
1
3
inosine transport in via proton symport, reversible (INSt2r)
1
h
-1
1
ins
-1
1
h
1
3
ins
1
3
adenosine transport in via proton symport, reversible (ADNt2r)
1
adn
-1
1
h
-1
1
adn
1
3
h
1
3
cytidine transport in via proton symport, reversible (CYTDt2r)
1
cytd
-1
1
h
-1
1
cytd
1
3
h
1
3
thymidine transport in via proton symport, reversible (THMDt2r)
1
h
-1
1
thymd
-1
1
h
1
3
thymd
1
3
uridine transport in via proton symport, reversible (URIt2r)
1
h
-1
1
uri
-1
1
h
1
3
uri
1
3
D-xylose transport in via proton symport (XYLt2)
0
h
-1
1
xyl-D
-1
1
h
1
3
xyl-D
1
3
D-xylose transport via ABC system (XYLabc)
0
atp
-1
3
h2o
-1
3
xyl-D
-1
1
adp
1
3
h
1
3
pi
1
3
xyl-D
1
3
choline transport via proton symport, reversible (CHLt2r)
1
chol
-1
1
h
-1
1
chol
1
3
h
1
3
adenine transport via proton symport (reversible) (ADEt2r)
1
ade
-1
1
h
-1
1
ade
1
3
h
1
3
D-ribose transport via ABC system (RIBabc)
0
atp
-1
3
h2o
-1
3
rib-D
-1
1
adp
1
3
h
1
3
pi
1
3
rib-D
1
3
Tyrosine, Tryptophan, and Phenylalanine Metabolism
3-phosphoshikimate 1-carboxyvinyltransferase (PSCVT)
EC-2.5.1.19
1
pep
-1
3
skm5p
-1
3
3psme
1
3
pi
1
3
3-dehydroquinate synthase (DHQS)
0
2dda7p
-1
3
3dhq
1
3
pi
1
3
chorismate synthase (CHORS)
EC-4.2.3.5
0
3psme
-1
3
chor
1
3
pi
1
3
3-dehydroquinate dehydratase (DHQD)
EC-4.2.1.10
1
3dhq
-1
3
3dhsk
1
3
h2o
1
3
shikimate dehdrogenase (SHK3Dr)
EC-1.1.1.25
1
3dhsk
-1
3
h
-1
3
nadph
-1
3
nadp
1
3
skm
1
3
3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase (DDPA)
EC-4.1.2.15
0
e4p
-1
3
h2o
-1
3
pep
-1
3
2dda7p
1
3
pi
1
3
shikimate kinase (SHKK)
EC-2.7.1.71
0
atp
-1
3
skm
-1
3
adp
1
3
h
1
3
skm5p
1
3
prephenate dehydratase (PPNDH)
EC-4.2.1.51
0
h
-1
3
pphn
-1
3
co2
1
3
h2o
1
3
phpyr
1
3
chorismate mutase (CHORM)
EC-5.4.99.5
0
chor
-1
3
pphn
1
3
Tryptophanase (L-tryptophan) (TRPAS2)
EC-4.1.99.1
1
h2o
-1
3
trp-L
-1
3
indole
1
3
nh4
1
3
pyr
1
3
tryptophan synthase (indole) (TRPS2)
EC-4.2.1.20
0
indole
-1
3
ser-L
-1
3
h2o
1
3
trp-L
1
3
tryptophan synthase (indoleglycerol phosphate) (TRPS3)
EC-4.2.1.20
0
3ig3p
-1
3
g3p
1
3
indole
1
3
tryptophan synthase (indoleglycerol phosphate) (TRPS1)
EC-4.2.1.20
0
3ig3p
-1
3
ser-L
-1
3
g3p
1
3
h2o
1
3
trp-L
1
3
phosphoribosylanthranilate isomerase (irreversible) (PRAIi)
EC-5.3.1.24
0
pran
-1
3
2cpr5p
1
3
indole-3-glycerol-phosphate synthase (IGPS)
EC-4.1.1.48
0
2cpr5p
-1
3
h
-1
3
3ig3p
1
3
co2
1
3
h2o
1
3
anthranilate synthase (ANS)
EC-4.1.3.27
0
chor
-1
3
gln-L
-1
3
anth
1
3
glu-L
1
3
h
1
3
pyr
1
3
anthranilate phosphoribosyltransferase (ANPRT)
EC-2.4.2.18
0
anth
-1
3
prpp
-1
3
ppi
1
3
pran
1
3
prephenate dehydrogenase (PPND)
EC-1.3.1.12
0
nad
-1
3
pphn
-1
3
34hpp
1
3
co2
1
3
nadh
1
3
tyrosine transaminase (TYRTA)
EC-2.6.1.5
1
akg
-1
3
tyr-L
-1
3
34hpp
1
3
glu-L
1
3
phenylalanine transaminase (PHETA1)
EC-2.6.1.58
1
akg
-1
3
phe-L
-1
3
glu-L
1
3
phpyr
1
3
Unassigned
ATP maintenance requirement (ATPM)
0
atp
-1
3
h2o
-1
3
adp
1
3
h
1
3
pi
1
3
betaine-aldehyde dehydrogenase (BETALDHx)
EC-1.2.1.8
0
betald
-1
3
h2o
-1
3
nad
-1
3
glyb
1
3
h
2
3
nadh
1
3
betaine-aldehyde dehydrogenase (BETALDHy)
EC-1.2.1.8
0
betald
-1
3
h2o
-1
3
nadp
-1
3
glyb
1
3
h
2
3
nadph
1
3
HCO3 equilibration reaction (HCO3E)
1
co2
-1
3
h2o
-1
3
h
1
3
hco3
1
3
Cyanide sulfurtransferase (CYANST)
EC-2.8.1.1
0
cyan
-1
3
tsul
-1
3
h
1
3
so3
1
3
tcynt
1
3
catalase (CAT)
EC-1.11.1.6
0
h2o2
-2
3
h2o
2
3
o2
1
3
Selenophosphate synthase (SELNPS)
EC-2.7.9.3
0
atp
-1
3
h2o
-1
3
seln
-1
3
amp
1
3
pi
1
3
selnp
1
3
superoxide dismutase (SPODM)
EC-1.15.1.1
0
h
-2
3
o2-
-2
3
h2o2
1
3
o2
1
3
Trans-aconitate methyltransferase (ACONMT)
0
acon-T
-1
3
amet
-1
3
aconm
1
3
ahcys
1
3
Valine, leucine, and isoleucine metabolism
L-threonine deaminase (THRD_L)
0
thr-L
-1
3
2obut
1
3
nh4
1
3
2-aceto-2-hydroxybutanoate synthase (ACHBS)
0
2obut
-1
3
h
-1
3
pyr
-1
3
2ahbut
1
3
co2
1
3
acetolactate synthase (ACLS)
EC-4.1.3.18
0
h
-1
3
pyr
-2
3
alac-S
1
3
co2
1
3
ketol-acid reductoisomerase (2-Aceto-2-hydroxybutanoate) (KARA2i)
EC-1.1.1.86
0
2ahbut
-1
3
h
-1
3
nadph
-1
3
23dhmp
1
3
nadp
1
3
acetohydroxy acid isomeroreductase (KARA1i)
EC-1.1.1.86
0
alac-S
-1
3
h
-1
3
nadph
-1
3
23dhmb
1
3
nadp
1
3
Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) (DHAD2)
0
23dhmp
-1
3
3mop
1
3
h2o
1
3
dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) (DHAD1)
EC-4.2.1.9
0
23dhmb
-1
3
3mob
1
3
h2o
1
3
isoleucine transaminase (ILETA)
EC-2.6.1.42
1
akg
-1
3
ile-L
-1
3
3mop
1
3
glu-L
1
3
valine transaminase (VALTA)
EC-2.6.1.42
1
akg
-1
3
val-L
-1
3
3mob
1
3
glu-L
1
3
leucine transaminase (irreversible) (LEUTAi)
EC-2.6.1.42
0
4mop
-1
3
glu-L
-1
3
akg
1
3
leu-L
1
3
2-isopropylmalate synthase (IPPS)
EC-4.1.3.12
0
3mob
-1
3
accoa
-1
3
h2o
-1
3
3c3hmp
1
3
coa
1
3
h
1
3
3-isopropylmalate dehydrogenase (IPMD)
EC-1.1.1.85
0
3c2hmp
-1
3
nad
-1
3
3c4mop
1
3
h
1
3
nadh
1
3
2-Oxo-4-methyl-3-carboxypentanoate decarboxylation (OMCDC)
0
3c4mop
-1
3
h
-1
3
4mop
1
3
co2
1
3
3-isopropylmalate dehydratase (IPPMIa)
EC-4.2.1.33
1
3c2hmp
-1
3
2ippm
1
3
h2o
1
3
2-isopropylmalate hydratase (IPPMIb)
EC-4.2.1.33
1
2ippm
-1
3
h2o
-1
3
3c3hmp
1
3