Cyanobacteria are an important group of photoautotrophic organisms that can synthesize valuable bio-products by harnessing solar energy. They are endowed with high photosynthetic efficiencies and diverse metabolic capabilities that confer the ability to convert solar energy into a variety of biofuels and their precursors. Genome-scale models were created for five species of Cyanothece using a workflow discussed in Mueller et al which uses the previously published iCyt773 model and reviewed annotations from the Uniprot and NCBI Protein Clusters databases and annotations generated from the RAST method.
The iCyn731 model of Cyanothece PCC 7425 contains 1306 reactions, 1160 metabolites, and 731 genes. It contains 149 reactions not found in any of the other 4 Cyanothece models generated in this study. All reactions are charge and elementally balanced and localized into four compartments, the cytosol, periplasm, thylakoid lumen, and carboxysome.
Mueller, T.J., Berla, B.M., Pakrasi, H.B., Maranas, C.D. (2013) "Rapid construction of metabolic models for a family of Cyanobacteria using a multiple source annotation workflow", BMC Systems Biology, 7(142).
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