Cyanobacteria are an important group of photoautotrophic organisms that can synthesize valuable bio-products by harnessing solar energy. They are endowed with high photosynthetic efficiencies and diverse metabolic capabilities that confer the ability to convert solar energy into a variety of biofuels and their precursors. Genome-scale models were created for five species of Cyanothece using a workflow discussed in Mueller et al which uses the previously published iCyt773 model and reviewed annotations from the Uniprot and NCBI Protein Clusters databases and annotations generated from the RAST method.

The iCyp752 model of Cyanothece PCC 8801 contains 1172 reactions, 994 metabolites, and 752 genes. It shares 30 reactions with iCyh755 that are not found in the other three models generated in this study. All reactions are charge and elementally balanced and localized into four compartments, the cytosol, periplasm, thylakoid lumen, and carboxysome.

Related Publications:

Mueller, T.J., Berla, B.M., Pakrasi, H.B., Maranas, C.D. (2013) "Rapid construction of metabolic models for a family of Cyanobacteria using a multiple source annotation workflow", BMC Systems Biology, 7(142).

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